Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Ken J Ishii"'
Autor:
Eita Sasaki, Haruka Momose, Yuki Hiradate, Keiko Furuhata, Mamiko Takai, Hideki Asanuma, Ken J Ishii, Takuo Mizukami, Isao Hamaguchi
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191896 (2018)
Historically, vaccine safety assessments have been conducted by animal testing (e.g., quality control tests and adjuvant development). However, classical evaluation methods do not provide sufficient information to make treatment decisions. We previou
Externí odkaz:
https://doaj.org/article/fd7c97d77a1c4d09a3cd0830e1ab154e
Autor:
Masanori Yagi, Gilles Bang, Takahiro Tougan, Nirianne M Q Palacpac, Nobuko Arisue, Taiki Aoshi, Yoshitsugu Matsumoto, Ken J Ishii, Thomas G Egwang, Pierre Druilhe, Toshihiro Horii
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98460 (2014)
The malaria vaccine candidate antigen, SE36, is based on the N-terminal 47 kDa domain of Plasmodium falciparum serine repeat antigen 5 (SERA5). In epidemiological studies, we have previously shown the inhibitory effects of SE36 specific antibodies on
Externí odkaz:
https://doaj.org/article/ca039e53734d4cca984f604e67ef3563
Autor:
Takuo Mizukami, Haruka Momose, Madoka Kuramitsu, Kazuya Takizawa, Kumiko Araki, Keiko Furuhata, Ken J Ishii, Isao Hamaguchi, Kazunari Yamaguchi
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101835 (2014)
Vaccines are beneficial and universal tools to prevent infectious disease. Thus, safety of vaccines is strictly evaluated in the preclinical phase of trials and every vaccine batch must be tested by the National Control Laboratories according to the
Externí odkaz:
https://doaj.org/article/d5382bc4c8374a56bf4391d70774bc72
Autor:
Choon Kit Tang, Taiki Aoshi, Nao Jounai, Junichi Ito, Keiichi Ohata, Kouji Kobiyama, Benoit H Dessailly, Etsushi Kuroda, Shizuo Akira, Kenji Mizuguchi, Cevayir Coban, Ken J Ishii
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60038 (2013)
5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a potent type I interferon (IFN) inducer, was evaluated as a chemotherapeutic agent in mouse cancer models and proved to be well tolerated in human cancer clinical trials. Despite its multiple biological
Externí odkaz:
https://doaj.org/article/ea094f7d4bfb48cf9ac352f2617c01e1
Autor:
Nirianne Marie Q Palacpac, Edward Ntege, Adoke Yeka, Betty Balikagala, Nahoko Suzuki, Hiroki Shirai, Masanori Yagi, Kazuya Ito, Wakaba Fukushima, Yoshio Hirota, Christopher Nsereko, Takuya Okada, Bernard N Kanoi, Kohhei Tetsutani, Nobuko Arisue, Sawako Itagaki, Takahiro Tougan, Ken J Ishii, Shigeharu Ueda, Thomas G Egwang, Toshihiro Horii
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64073 (2013)
BACKGROUND: Up to now a malaria vaccine remains elusive. The Plasmodium falciparum serine repeat antigen-5 formulated with aluminum hydroxyl gel (BK-SE36) is a blood-stage malaria vaccine candidate that has undergone phase 1a trial in malaria-naive J
Externí odkaz:
https://doaj.org/article/d468acc1b0e04be69ab69d838b9721bb
Autor:
Fadile Yildiz Zeyrek, Nirianne Palacpac, Fehmi Yuksel, Masanori Yagi, Kaori Honjo, Yukiko Fujita, Nobuko Arisue, Satoru Takeo, Kazuyuki Tanabe, Toshihiro Horii, Takafumi Tsuboi, Ken J Ishii, Cevayir Coban
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28126 (2011)
Plasmodium vivax infection has been gaining attention because of its re-emergence in several parts of the world. Southeastern Turkey is one of the places in which persistent focal malaria caused exclusively by P. vivax parasites occurs. Although cont
Externí odkaz:
https://doaj.org/article/ff38173bf756408da2b80ed638040295
Autor:
Izumi Sasaki, Yuri Fukuda-Ohta, Chihiro Nakai, Naoko Wakaki-Nishiyama, Chizuyo Okamoto, Daisuke Okuzaki, Shuhei Morita, Shiori Kaji, Yuki Furuta, Hiroaki Hemmi, Takashi Kato, Asumi Yamamoto, Emi Tosuji, Shin-Ichiroh Saitoh, Takashi Tanaka, Katsuaki Hoshino, Shinji Fukuda, Kensuke Miyake, Etsushi Kuroda, Ken J. Ishii, Takao Iwawaki, Koichi Furukawa, Tsuneyasu Kaisho
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113981- (2024)
Summary: Cholera toxin (CT), a bacterial exotoxin composed of one A subunit (CTA) and five B subunits (CTB), functions as an immune adjuvant. CTB can induce production of interleukin-1β (IL-1β), a proinflammatory cytokine, in synergy with a lipopol
Externí odkaz:
https://doaj.org/article/f22ab996a6a3412b82cc9ee0414c17dd
Autor:
Burcu Temizoz, Takayuki Shibahara, Kou Hioki, Tomoya Hayashi, Kouji Kobiyama, Michelle Sue Jann Lee, Naz Surucu, Erdal Sag, Atsushi Kumanogoh, Masahiro Yamamoto, Mayda Gursel, Seza Ozen, Etsushi Kuroda, Cevayir Coban, Ken J. Ishii
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a mouse-selective stimulator of interferon gene (STING) agonist exerting STING-dependent anti-tumor activity. Although DMXAA cannot fully activate human STING, DMXAA reached phase III in lung cancer cli
Externí odkaz:
https://doaj.org/article/96d6c342ff5a4b34983c9c8d51741ae6
Autor:
Chieko Yokota, Kosuke Fujimoto, Natsuko Yamakawa, Masamitsu Kono, Daichi Miyaoka, Masaki Shimohigoshi, Miho Uematsu, Miki Watanabe, Yukari Kamei, Akira Sugimoto, Natsuko Kawasaki, Takato Yabuno, Tomotaka Okamura, Eisuke Kuroda, Shigeto Hamaguchi, Shintaro Sato, Muneki Hotomi, Yukihiro Akeda, Ken J. Ishii, Yasuhiro Yasutomi, Kishiko Sunami, Satoshi Uematsu
Publikováno v:
Inflammation and Regeneration, Vol 43, Iss 1, Pp 1-12 (2023)
Abstract Background Although vaccination is recommended for protection against invasive pneumococcal disease, the frequency of pneumococcal pneumonia is still high worldwide. In fact, no vaccines are effective for all pneumococcal serotypes. Fusion p
Externí odkaz:
https://doaj.org/article/707122d771834299ab42a5fa158c5832
Autor:
Alphonse Ouédraogo, Edith Christiane Bougouma, Nirianne Marie Q. Palacpac, Sophie Houard, Issa Nebie, Jean Sawadogo, Gloria D. Berges, Issiaka Soulama, Amidou Diarra, Denise Hien, Amidou Z. Ouedraogo, Amadou T. Konaté, Seni Kouanda, Akira Myoui, Sachiko Ezoe, Ken J. Ishii, Takanobu Sato, Flavia D’Alessio, Odile Leroy, Alfred B. Tiono, Simon Cousens, Toshihiro Horii, Sodiomon B. Sirima
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundBK-SE36/CpG is a recombinant blood-stage malaria vaccine candidate based on the N-terminal Plasmodium falciparum serine repeat antigen5 (SE36), adsorbed to aluminium hydroxide gel and reconstituted, prior to administration, with synthetic o
Externí odkaz:
https://doaj.org/article/e22bb3de30e5466fbb0802c8e128c365