Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Ken Inouye"'
Publikováno v:
International Journal of Peptide and Protein Research. 21:541-545
The n.m.r. pattern of triostin A in weakly polar solvents was explained by the presence of two symmetrical conformers. Its S-benzyl derivative still shows the n.m.r. pattern of two conformers, while des-N-tetramethyltriostin A, which lacks the N-meth
Autor:
Yoshihiko Saito, Shin Ichi Suga, Yoshihiro Ogawa, Kazuwa Nakao, Yoshikazu Kambayashi, Gotaro Shirakami, Masashi Mukoyama, Hiroshi Arai, Kiminori Hosoda, Ken Inouye
Publikováno v:
Endocrinology. 130:229-239
To elucidate the ligand-receptor relationship of the natriuretic peptide system, which comprises at least three endogenous ligands, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), and three rec
Immunoradiometric assay for the N-terminal fragment of proatrial natriuretic peptide in human plasma
Autor:
Kazuwa Nakao, Hidehisa Asada, Kazuyuki Sasakura, Shino Kikuoka, Keiji Dohi, Takahiro Fukunaga, Ayako Furukawa, Masashi Mukoyama, Michihiro Yoshimura, Yasushi Taniguchi, Yoshito Numata, Hiroshi Itoh, Hirofumi Yasue, Tetsuo Tsuji, Ken Inouye
Publikováno v:
Clinical chemistry. 44(5)
Recently, the N-terminal fragment of proatrial natriuretic peptide (N-terminal proANP) has been proposed as a marker of chronic congestive heart failure. In this study, we established a two-step immunoradiometric assay using monoclonal antibodies and
Autor:
Hidesuke Masuda, Tetsuo Tsuji, Kazunori Shibata, Keiichi Imagawa, Ken Inouye, Makoto Haraikawa, Kiyohisa Uchida, Masao Kono
Publikováno v:
Clinica chimica acta; international journal of clinical chemistry. 225(2)
Autor:
Hiroo Imura, Yoshikazu Kambayashi, Kazuwa Nakao, Nobuo Yoshida, Ken Inouye, Tomoji Kawabata, Hiromi Kimura, Masuhisa Nakamura
Publikováno v:
Biochemical and biophysical research communications. 173(2)
We examined the diuretic-natriuretic activities of rat BNP and human BNP in anesthetized rats in vivo and their vasorelaxant activities for rat thoracic aorta and porcine coronary artery in vitro. Rat BNP was almost equipotent to rat ANP in diuresis
Autor:
Hikari Miyashita, Masao Kono, Tetsuro Kobayashi, Koji Nakanishi, Ken Inouye, Tadao Sugimoto, Kinori Kosaka, Toshio Murase, Minoru Ohkubo
Publikováno v:
Metabolism: clinical and experimental. 39(9)
Relationships among islet cell antibodies (ICA), residual beta-cell function, and metabolic control were studied in 60 insulin-dependent diabetics (IDDs) of long duration (6 to 31 years). Sensitive C-peptide immunoreactivity (CPR) and ICA assays with
Autor:
Gotaro Shirakami, Ken Inouye, Yoshihiro Ogawa, Kiminori Hosoda, Shin Ichi Suga, Hiroshi Arai, Yoshikazu Kambayashi, Kazuwa Nakao, Michihisa Jougasaki, Masashi Mukoyama, Hiroo Imura, Yoshihiko Saito, Takayuki Yamada, Hiroshi Itoh
Publikováno v:
Endocrinology. 126(4)
Using an antiserum against the ring structure of rat brain natriuretic peptide (rat BNP), we have established a specific radioimmunoassay (RIA) for rat BNP and elucidated its tissue distribution and molecular form. Rat BNP-like immunoreactivity (-LI)
Autor:
Ken Inouye, Yoshihiro Ogawa, Shozo Shiono, Nobuo Yoshida, Yoshikazu Kambayashi, Masashi Mukoyama, Yoshihiko Saito, Hiroo Imura, Kazuwa Nakao
Publikováno v:
FEBS letters. 259(2)
We isolated human brain natriuretic peptide (human BNP) from the human atrium. Sequence analysis has revealed that it is a 32-amino-acid peptide with the sequence S-P-K-M-V-Q-G-S-G-C-F-G-R-K-M-D-R-I-S-S-S-S-G-L-G-C-K-V-L-R-R-H, which is identical to
Autor:
Tetsuro Haruta, Osamu Ishibashi, Yukio Shigeta, Makoto Iwasaki, Yasumitsu Takata, Masashi Kobayashi, Ken Inouye, Nobuaki Watanabe, Toshiyasu Sasaoka
Publikováno v:
Diabetes Research and Clinical Practice. 2:257-262
Summary The metabolism of a mutant insulin, [Leu B25 ]-insulin, was studied in vitro and in vivo. Porcine or mutant insulin (4 μg/kg body weight) was injected i.v. into streptozotocin-induced diabetic rats and their plasma glucose and insulin levels
Autor:
Ken Inouye, Ken'ichi Igano, Itsuko Irie, Tadashi Okabayashi, Kunio Watanabe, Masafumi Fujimoto
Publikováno v:
Biochemical Pharmacology. 34:1103-1107
A number of caerulein (CLN)-related peptides were synthesized and compared in terms of their affinities for cholecystokinin (CCK) receptors. We have found that these peptides can be classified into three types according to their relative affinities f