Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ken Ichiro Takagi"'
Autor:
G. Satyanarayana Reddy, Daisuke Sawada, Masashi Takano, Miyu Nishikawa, Tai C. Chen, Kaori Yasuda, Kyohei Horie, Atsushi Kittaka, Ken Ichiro Takagi, Akiko Takeuchi, Toshiyuki Sakaki
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 148:34-37
Three different A-ring perhydroxylated trihydroxyvitamin D3 metabolites were synthesized from their appropriate A-ring precursors and CD-ring for their potential therapeutic applications. We first chemically synthesized 1α,2α,25-trihydroxyvitamin D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94212d0251e0003650271e2eaf691521
https://doi.org/10.1016/j.jsbmb.2014.09.021
https://doi.org/10.1016/j.jsbmb.2014.09.021
Autor:
Ken Ichiro Takagi, Kazuya Takenouchi, Toshiyuki Sakaki, Kaori Yasuda, Daisuke Sawada, Tai C. Chen, Yuya Tsukuda, Hiroshi Saito, G. Satyanarayana Reddy, Atsushi Kittaka
Publikováno v:
Chemical and Pharmaceutical Bulletin. 60:1343-1346
A previous report has demonstrated the existence of a C4-hydroxylated vitamin D(2) metabolite in serum of rats treated with pharmacological doses of vitamin D(2). However, the biological significance and metabolic fate of this metabolite have not bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5407b1d78b51f718a74f9479d42c2182
https://doi.org/10.1248/cpb.c12-00526
https://doi.org/10.1248/cpb.c12-00526
Autor:
Masashi Takano, Hiroshi Saito, Seiichi Ishizuka, Nozomi Saito, Eiji Ochiai, Atsushi Kittaka, Shinji Kakuda, Kanako Shindo, Kyohei Horie, Midori Takimoto-Kamimura, Ken Ichiro Takagi, Go Kumagai, Daisuke Sawada, Kazuya Takenouchi
Publikováno v:
Organic Letters. 13:2852-2855
C15-Substituted 1α,25-dihydroxyvitamin D(3) analogs were synthesized for the first time to investigate the effects of the modified CD-ring on biological activity concerning the agonistic positioning of helix-3 and helix-12 of the vitamin D receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f988d030c8cebf6797d3750a5c8e6a
https://doi.org/10.1021/ol200828s
https://doi.org/10.1021/ol200828s
Autor:
Hiroshi Saito, Eiji Ochiai, Seiichi Ishizuka, Nozomi Saito, Atsushi Kittaka, Ken Ichiro Takagi, Yuya Tsukuda, Tomoyuki Katayama, Daisuke Sawada, Kazuya Takenouchi
Publikováno v:
Tetrahedron. 66:5407-5423
2α- and 2β-Substituted analogs of 14-epi-previtamin D3 were synthesized and isolated after thermal isomerization of 14-epi-vitamin D3 triene at 80 °C. The VDR binding affinity and transactivation activity of osteocalcin promoter in HOS cells were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a93b67ab2fa7092ddc38c6b0cfc60cfc
https://doi.org/10.1016/j.tet.2010.05.028
https://doi.org/10.1016/j.tet.2010.05.028
Autor:
Eiji Ochiai, Seiichi Ishizuka, Nozomi Saito, Daisuke Sawada, Atsushi Kittaka, Kazuya Takenouchi, Tomoyuki Katayama, Masashi Takano, Yuya Tsukuda, Ken Ichiro Takagi, Hiroshi Saito
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5397-5400
We synthesized and isolated 2 alpha-substituted analogs of 14-epi-previtamin D3 after thermal isomerization at 80 degrees C for the first time. The VDR binding affinity and transactivation activity of osteocalcin promoter in HOS cells were evaluated,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9b0e62d5ff848ad8b19ec2a0f77d60
https://doi.org/10.1016/j.bmcl.2009.07.112
https://doi.org/10.1016/j.bmcl.2009.07.112
Autor:
Yuya Tsukuda, Atsushi Kittaka, Hiroshi Saito, Kyouhei Horie, Eiji Ochiai, Ken Ichiro Takagi, Daisuke Sawada, Kazuya Takenouchi
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 57:1431-1433
We synthesized the 4-hydroxy and 4-methoxy analogs of active vitamin D(3) (1alpha,25(OH)(2)D(3), 1) and its C14-epimer with the previtamin D(3) form of 14-epi-1alpha,25(OH)(2)preD(3) (14-epi-pre1). Their vitamin D receptor (VDR) binding affinity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a147ea28169e532f06e03faaea68b5b3
https://doi.org/10.1248/cpb.57.1431
https://doi.org/10.1248/cpb.57.1431
Autor:
Kazuo Sakka, Shuichi Karita, Hidenori Hayashi, Masayuki Fukumura, Tetsuya Kimura, Ken-Ichiro Takagi, Kunio Ohmiya
Publikováno v:
Journal of Bacteriology. 179:4246-4253
The nucleotide sequence of the Clostridium thermocellum F1 xynC gene, which encodes the xylanase XynC, consists of 1,857 bp and encodes a protein of 619 amino acids with a molecular weight of 69,517. XynC contains a typical N-terminal signal peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ce6377adc5b081de44838c311c83c9
https://doi.org/10.1128/jb.179.13.4246-4253.1997
https://doi.org/10.1128/jb.179.13.4246-4253.1997
Autor:
Masashi Takano, Yoshifumi Harada, Miki Matsuo, Kazuya Takenouchi, Daisuke Sawada, Asami Hasegawa, Atsushi Kittaka, Hiroshi Saito, Takayuki Chida, Kyohei Horie, Midori Takimoto-Kamimura, Shinji Kakuda, Eiji Ochiai, Ken Ichiro Takagi
Publikováno v:
ACS medicinal chemistry letters. 4(7)
2α-Heteroarylethyl-1α,25-dihydroxyvitamin D3 analogues, which were designed to form a hydrogen bond between Arg274 of human vitamin D receptor (hVDR) and a nitrogen atom of the heteroaromatic ring at the 2α-position, were synthesized. Among them,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b228a65114323573538317797f5ac90
https://pubmed.ncbi.nlm.nih.gov/24900728
https://pubmed.ncbi.nlm.nih.gov/24900728
Autor:
Daisuke, Sawada, Yuya, Tsukuda, Kaori, Yasuda, Toshiyuki, Sakaki, Hiroshi, Saito, Ken-ichiro, Takagi, Kazuya, Takenouchi, Tai C, Chen, G Satyanarayana, Reddy, Atsushi, Kittaka
Publikováno v:
Chemicalpharmaceutical bulletin. 60(10)
A previous report has demonstrated the existence of a C4-hydroxylated vitamin D(2) metabolite in serum of rats treated with pharmacological doses of vitamin D(2). However, the biological significance and metabolic fate of this metabolite have not bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f8aecfc3757d4d067c95aa3ba1ab0d6
https://pubmed.ncbi.nlm.nih.gov/23036975
https://pubmed.ncbi.nlm.nih.gov/23036975
Autor:
Go, Kumagai, Masashi, Takano, Kanako, Shindo, Daisuke, Sawada, Nozomi, Saito, Hiroshi, Saito, Shinji, Kakuda, Ken-ichiro, Takagi, Midori, Takimoto-Kamimura, Kazuya, Takenouchi, Tai C, Chen, Atsushi, Kittaka
Publikováno v:
Anticancer research. 32(1)
The Δ(16) structure as a vitamin D analog enhanced vitamin D receptor (VDR) binding affinity and induced significant cell differentiation, whereas its relative calcemic activity was reduced compared to 1α,25-dihydroxyvitamin D(3) (1α,25(OH)(2)D(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a22ee3334025e359ac358667342568d8
https://pubmed.ncbi.nlm.nih.gov/22213321
https://pubmed.ncbi.nlm.nih.gov/22213321