Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Ken Ichiro Fukuchi"'
Publikováno v:
PLoS ONE, Vol 18, Iss 7, p e0288497 (2023)
In order to study effects of macrophage-derived inflammatory mediators associated with systemic inflammation on brain endothelial cells, we have established a co-culture system consisting of bEnd.3 cells and LPS-activated Raw 264.7 cells and performe
Externí odkaz:
https://doaj.org/article/8c28c547e0bf42fdb8c6e81417532f06
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Amyloid plaques, mainly composed of abnormally aggregated amyloid β-protein (Aβ) in the brain parenchyma, and neurofibrillary tangles (NFTs), consisting of hyperphosphorylated tau protein aggregates in neurons, are two pathological hallmarks of Alz
Externí odkaz:
https://doaj.org/article/9090051311594c3fb6fbb33918a39704
Autor:
Junling Yang, Ken-Ichiro Fukuchi
Publikováno v:
International Journal of Endocrinology, Vol 2020 (2020)
Obesity significantly increases the risk of developing type 2 diabetes mellitus and other metabolic diseases. Obesity is associated with chronic low-grade inflammation in white adipose tissues, which is thought to play an essential role in developing
Externí odkaz:
https://doaj.org/article/cf31c17dd9f04a41866fd9042968a01d
Autor:
Robert C Caughey, Jeong Eun Lim, Michelle S. Go, Junling Yang, Ken-ichiro Fukuchi, Jinghong Kou, Fiona Malone
Publikováno v:
J Mol Neurosci
Repeated exposure to toll-like receptor 4 (TLR4) ligands, such as lipopolysaccharide (LPS), reduces responses of monocytes/macrophages to LPS (LPS/endotoxin tolerance). Microglial exposure to Aβ deposits, a TLR4 ligand, may cause "Aβ/LPS tolerance,
Autor:
Ken-ichiro Fukuchi, Kazuki Tahara, Hong-Duck Kim, J. Adam Maxwell, Terry L. Lewis, Mary Ann Accavitti-Loper, Helen Kim, Selvarangan Ponnazhagan, Robert Lalonde
Publikováno v:
Neurobiology of Disease, Vol 23, Iss 3, Pp 502-511 (2006)
Immunization of mouse models of Alzheimer disease (AD) with amyloid-peptide (Aβ) reduces Aβ deposits and attenuates their memory and learning deficits. Recent clinical trials were halted due to meningoencephalitis, presumably induced by T cell medi
Externí odkaz:
https://doaj.org/article/5342686ae55c4d508cefe9fe3ba633db
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
Amyloid plaques, mainly composed of abnormally aggregated amyloid β-protein (Aβ) in the brain parenchyma, and neurofibrillary tangles (NFTs), consisting of hyperphosphorylated tau protein aggregates in neurons, are two pathological hallmarks of Alz
Autor:
Stephanie Planque, Jinghong Kou, Sudhir Paul, Ken-ichiro Fukuchi, Junling Yang, Min Song, Robert Lalonde
The amyloid hypothesis has been the main theory to explain the etiology of Alzheimer’s disease (AD) and provided potentially preventive and therapeutic targets. Although Aβ-immunotherapy holds promise for AD, its vascular complications reduce the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::439a4dd6ac1539e381f5e3c360720beb
https://doi.org/10.1016/b978-0-12-809813-4.00006-5
https://doi.org/10.1016/b978-0-12-809813-4.00006-5
Autor:
Christopher S. Ahuja, Marta M. Alonso, Victor L. Arvanian, Jacob I. Ayers, Paramita Chakrabarty, Rajeev K. Chaudhary, Zhiguo Chen, Leah Czerniewski, Dongsheng Duan, Michael G. Fehlings, Dahna M. Fong, Juan Fueyo, Ken-ichiro Fukuchi, Yandi Gao, Candelaria Gomez-Manzano, Renzhi Han, Zongchao Han, Shuanglin Hao, David M. Holtzman, Kyeung M. Joo, Jillian L. Joyce, Michael G. Kaplitt, Mohamad Khazaei, Kasun Kodippili, Jinghong Kou, Andrew W. Kraft, Sebastian Kügler, Robert Lalonde, Jin-Moo Lee, Young E. Lee, Mingjie Li, Roberta Marongiu, Naiara Martínez-Vélez, Kinjal A. Patel, Ana Patiño-García, Sudhir Paul, Hayk A. Petrosyan, Stephanie A. Planque, JeeHoon Roh, Zachary P. Rosenthal, Ipsita Roy, Ahad M. Siddiqui, B. Joy Snider, Min Song, Shuyan Wang, Matthew D. Wood, Angela Wu, Li Xu, Junling Yang, Deborah Young, Yu Alex Zhang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52eb4d6d154f0757a12f2acb3eb9fc39
https://doi.org/10.1016/b978-0-12-809813-4.00026-0
https://doi.org/10.1016/b978-0-12-809813-4.00026-0
Publikováno v:
Brain, Behavior, and Immunity
Brain, Behavior, and Immunity, Elsevier, 2017, 65, pp.262-273. ⟨10.1016/j.bbi.2017.05.012⟩
Brain, Behavior, and Immunity, Elsevier, 2017, 65, pp.262-273. ⟨10.1016/j.bbi.2017.05.012⟩
International audience; Neuroinflammation is a pervasive feature of Alzheimer's disease (AD) and characterized by activated microglia, increased proinflammatory cytokines and/or infiltrating immune cells. T helper 17 (Th17) cells are found in AD brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721c229ae38eb3f9429d36c71d2bb2fb
http://hdl.handle.net/20.500.12278/29829
http://hdl.handle.net/20.500.12278/29829
Work in multiple organs has suggested that toll-like receptor 4 (TLR4) may play a role in insulin resistance. Additional studies have shown a negative role for TLR4 on retinal health. We have previously reported that β-adrenergic receptors can regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d827629e84cf8ac4fd7518f58261401
https://europepmc.org/articles/PMC5896291/
https://europepmc.org/articles/PMC5896291/