Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ken Ichi Higashino"'
Autor:
Toshiyuki Asaki, Minoru Hasegawa, Yusuke Sakurai, Ken-ichi Higashino, Yasuhide Morioka, Kiyotaka Mochizuki, Takao Sanaki, Masahide Fujita, Tatsuya Takahashi, Takeshi Yoshioka
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO3-2
Autor:
Ken-ichi Higashino, Kohji Hanasaki, Yasunori Yokota, Yoshikazu Ishimoto, Kazumi Nakano, Mitsuru Notoya, Hitoshi Arita
Publikováno v:
FEBS Letters. 509:250-254
Given the potent hydrolyzing activity toward phosphatidylcholine, group X secretory phospholipase A(2) (sPLA(2)-X) elicits a marked release of arachidonic acid linked to the potent production of lipid mediators in various cell types. We have recently
Autor:
Minoru Ikeda, Keiko Kawamoto, Ken-ichi Higashino, Kohji Hanasaki, Yasunori Yokota, Noriko Fujii, Noriko Suzuki, Takashi Ono, Jun Ishizaki
Publikováno v:
Journal of Biological Chemistry. 275:5785-5793
Mammalian secretory phospholipase A(2)s (sPLA(2)s) form a family of structurally related enzymes that are involved in a variety of physiological and pathological processes via the release of arachidonic acid from membrane phospholipids or the binding
Autor:
Takashi Ono, Keiko Kawamoto, Katsutoshi Yamada, Ken-ichi Higashino, Kohji Hanasaki, Akihiko Saiga, Minoru Ikeda, Kazumi Nakano, Hitoshi Arita, Yasuhide Morioka, Jun Ishizaki
Publikováno v:
Journal of Biological Chemistry. 274:34203-34211
Group X secretory phospholipase A(2) (sPLA(2)-X) possesses several structural features characteristic of both group IB and IIA sPLA(2)s (sPLA(2)-IB and -IIA) and is postulated to be involved in inflammatory responses owing to its restricted expressio
Autor:
Keizo Inoue, Masakuni Horiguchi, Makoto Murakami, Ken Ichi Higashino, Hiroyuki Arai, Satoko Shimbara, Ichiro Kudo, Terumi Kambe, Kohji Hanasaki, Hitoshi Arita, Makoto Arita
Publikováno v:
Journal of Biological Chemistry. 274:31435-31444
We have recently reported that members of the heparin-binding group II subfamily of secretory PLA(2)s (sPLA(2)s) (types IIA and V), when transfected into 293 cells, released [(3)H]arachidonic acid (AA) preferentially in response to interleukin-1 (IL-
Autor:
Jun Ishizaki, Noriko Suzuki, Hitoshi Arita, Takashi Ono, Noriko Fujii, Ken-ichi Higashino, Kohji Hanasaki, Keiko Kawamoto, Yasunori Yokota
Publikováno v:
Journal of Biological Chemistry. 274:24973-24979
Mammalian secretory phospholipase A(2)s (sPLA(2)s) are classified into several groups according to molecular structure and the localization of intramolecular disulfide bridges. Among them, group IIA sPLA(2) has been thought to be one of the key enzym
Autor:
Ken-ichi Higashino, Tatsuyuki Furukawa, Keiji Akashi, Hideki Kondo, Shigemi Tanaka, Manabu Miyazaki, Ziro Kaneko, Tsuyoshi Nishimura, Tatsuhiko Sumi
Publikováno v:
Neurosonology. 4:28-33
To investigate the effect of cigarette smoking on human circulatory systems, five healthy male smokers were assigned to smoke a high nicotine cigarette for 5 minutes. Before, during and after smoking we recorded blood pressure, heart rate, respirator
Autor:
Ken-ichi Higashino, Tatsuyuki Furukawa, Keiji Akashi, Hideki Kondo, Ziro Kaneko, Tsuyoshi Nishimura, Manabu Miyazaki, Tatsuhiko Sumi, Shigemi Tanaka, Goichi Makinaga
Publikováno v:
Neurosonology. 3:7-11
We recorded the change of blood flow velocity before, during and after hyperventilation (HV) in bilateral Internal Carotid Arteries (ICA) and Vertebral Arteries (VA) simultaneously and continuously of 4 healthy males.The MULTI-DOPPLER-SYSTEM (HAYASHI
Autor:
Shigeki Kamitani, Yasunori Yokota, Hitoshi Arita, Takashi Ono, Ken-ichi Higashino, Kohji Hanasaki
Publikováno v:
The Journal of biological chemistry. 277(16)
Venomous snakes have various types of phospholipase A(2) inhibitory proteins (PLIs) in their circulatory system to protect them from attack by their own phospholipase A(2)s (PLA(2)s). Here we show the first evidence for the existence of circulating P
Publikováno v:
The Biochemical journal. 323
Gas6 (encoded by growth-arrest-specific gene 6) is a γ-carboxyglutamic acid (Gla)-containing protein which is released from growth-arrested vascular smooth muscle cells (VSMCs) and potentiates VSMC proliferation induced by Ca2+-mobilizing growth fac