Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ken I. Mitchelhill"'
Autor:
B. Paul Morgan, Peter J. Cowan, Bruce E. Kemp, David A. Power, Brendan F. Murphy, Ken I. Mitchelhill, Jennifer L. McRae
Publikováno v:
Journal of Biological Chemistry. 276:6747-6754
A novel human plasma protein has been identified as a universal component of complement deposits, when complement is detected immunohistochemically in vivo. The protein is homologous to complement factor H and related proteins and has been designated
Autor:
Paul Greengard, Tony Tiganis, Andrew J. Czernik, Bruce E. Kemp, Ken I. Mitchelhill, Jörg Heierhorst, Richard J. Mann
Publikováno v:
Biochemical Journal. 344:577-583
The mammalian S100A1 protein can activate the invertebrate myosin-associated giant protein kinase twitchin in a Ca2+-dependent manner by more than 1000-fold in vitro; however, no mammalian S100-dependent protein kinases are known. In an attempt to id
Autor:
Zhi-Ping Chen, Ken I. Mitchelhill, Bruce E. Kemp, Belinda J. Michell, Lee A. Witters, David Stapleton
Publikováno v:
Trends in Biochemical Sciences. 24:22-25
The AMP-activated protein kinase (AMPK) is a member of a metabolite-sensing protein kinase family that is found in all eukaryotes. AMPK activity is regulated by vigorous exercise, nutrient starvation and ischemia/hypoxia, and modulates many aspects o
Autor:
Ken I. Mitchelhill, Lee A. Witters, Bruce E. Kemp, Frosa Katsis, Belinda J. Michell, Colin M. House, David Stapleton
Publikováno v:
Journal of Biological Chemistry. 271:28445-28450
The 5'-AMP-activated protein kinase (AMPK) mediates several cellular responses to metabolic stress. Rat liver contains at least two isoforms of this enzyme, either alpha1 or alpha2 catalytic subunits together with beta and gamma noncatalytic subunits
Autor:
Sara S. Hook, Arthur M. Edelman, Elaine G. Goldstein, David Stapleton, Bruce E. Kemp, Ken I. Mitchelhill, Anthony R. Means, Kristin A. Anderson, Michele A. Selbert
Publikováno v:
Journal of Biological Chemistry. 271:10806-10810
We have purified to near homogeneity from rat brain two Ca-calmodulin-dependent protein kinase I (CaM kinase I) activating kinases, termed here CaM kinase I kinase-α and CaM kinase I kinase-β (CaMKIKα and CaMKIKβ, respectively). Both CaMKIKα and
Autor:
T. Cox, Lee A. Witters, Bruce E. Kemp, Colin M. House, David Stapleton, Trazel Teh, Ken I. Mitchelhill, Belinda J. Michell, Jane Widmer, C. S. Fernandez, Guang Gao
Publikováno v:
Journal of Biological Chemistry. 271:611-614
The mammalian 5'-AMP-activated protein kinase (AMPK) is related to a growing family of protein kinases in yeast and plants that are regulated by nutritional stress. We find the most prominent expressed form of the hepatic AMPK catalytic subunit (alph
Publikováno v:
Journal of Biological Chemistry. 268:12484-12491
Smooth muscle myosin light chain kinase (MLCK) is stable in the presence of Ca2+/calmodulin and does not undergo inactivation as reported for skeletal muscle MLCK (Kennelly, P.J., Starovasnik, M.A., Edelman, A.M., and Krebs, E.G. (1990) J. Biol. Chem
Autor:
Robert G. Ramsay, Daniel Ciznadija, Catherine Sicurella, Nancy Reyes, Ken I. Mitchelhill, Giovanna M. D'Abaco, Theo Mantamadiotis, Phillip K. Darcy
Publikováno v:
DNA and cell biology. 24(1)
Blocked differentiation is a hallmark of cancer cells and the restoration of differentiation programs in vivo is an actively pursued clinical aim. Understanding the key regulators of cyto-differentiation may focus therapies on molecules that reactiva
Autor:
Bruce E. Kemp, Geoffrey C. Nicholson, Anna Jane Fenton, R Hammonds, Jane M. Moseley, Thomas J. Martin, Ken I. Mitchelhill
Publikováno v:
Endocrinology. 129:3424-3426
We have recently shown that a carboxyl-terminal sequence of parathyroid hormone-related protein, PTHrP[107–139], is a potent direct inhibitor of osteoclastic bone resorption. We now report that this bone resorption inhibitory activity, which we hav
Autor:
Colin M. House, T. John Martin, Matthew T. Gillespie, Mark H.C. Lam, Alina Cures, Bruce E. Kemp, Tony Tiganis, Robert G. Ramsay, Boris Sarcevic, Ken I. Mitchelhill
Publikováno v:
The Journal of biological chemistry. 274(26)
Parathyroid hormone-related protein (PTHrP) is expressed by a wide variety of cells and is considered to act as a secreted factor; however, evidence is accumulating for it to act in an intracrine manner. We have determined that PTHrP localizes to the