Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Ken Haynes"'
Autor:
Yogesh Chaudhari, Timothy C. Cairns, Yaadwinder Sidhu, Victoria Attah, Graham Thomas, Michael Csukai, Nicholas J. Talbot, David J. Studholme, Ken Haynes
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 32, Iss 12, Pp 1564-1570 (2019)
Libraries of protein-encoding sequences can be generated by identification of open reading frames (ORFs) from a genome of choice that are then assembled into collections of plasmids termed ORFeome libraries. These represent powerful resources to faci
Externí odkaz:
https://doaj.org/article/951f917adec14772a3343906bb73a98b
Autor:
Bhawna Yadav, Héctor M. Mora-Montes, Jeanette Wagener, Iain Cunningham, Lara West, Ken Haynes, Alistair J.P. Brown, Neil A.R. Gow
Publikováno v:
The Cell Surface, Vol 6, Iss , Pp 100042- (2020)
We designed experiments to assess whether fungal cell wall mannans function as an immune shield or an immune agonist. Fungal cell wall β-(1,3)-glucan normally plays a major and dominant role in immune activation. The outer mannan layer has been vari
Externí odkaz:
https://doaj.org/article/10e6728ceb1f40eabb308af5de4c59a3
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Candida species are important pathogens of humans and the fourth most commonly isolated pathogen from nosocomial blood stream infections. Although Candida albicans is the principle causative agent of invasive candidosis, the incidence of Candida glab
Externí odkaz:
https://doaj.org/article/1b57275424704dfda0383566744114aa
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 5, Pp 1637-1647 (2018)
Candida glabrata (C. glabrata) forms part of the normal human gut microbiota but can cause life-threatening invasive infections in immune-compromised individuals. C. glabrata displays high resistance to common azole antifungals, which necessitates ne
Externí odkaz:
https://doaj.org/article/6435cfa5680c48698152e76074f571de
Autor:
Jane Usher, Ken Haynes
Publikováno v:
PLoS Genetics, Vol 15, Iss 8, p e1008259 (2019)
Drug resistance is a rapidly emerging concern, thus prompting the development of novel therapeutics or combinatorial therapy. Currently, combinatorial therapy targets are based on knowledge of drug mode of action and/or resistance mechanisms, constra
Externí odkaz:
https://doaj.org/article/ae649d4b22f743a5a6ab040e6d210f4d
Publikováno v:
Biomolecules, Vol 8, Iss 4, p 130 (2018)
Candida glabrata biofilms are recognized to have high resistance to antifungals. In order to understand the effect of mannans in the resistance profile of C. glabrata mature biofilms, C. glabrata Δmnn2 was evaluated. Biofilm cell walls were analysed
Externí odkaz:
https://doaj.org/article/6da209f8eeb1403db6c04664b3b60fae
Autor:
Markus Schrettl, Elaine Bignell, Claudia Kragl, Yasmin Sabiha, Omar Loss, Martin Eisendle, Anja Wallner, Herbert N Arst, Ken Haynes, Hubertus Haas
Publikováno v:
PLoS Pathogens, Vol 3, Iss 9, Pp 1195-1207 (2007)
Siderophore biosynthesis by the highly lethal mould Aspergillus fumigatus is essential for virulence, but non-existent in humans, presenting a rare opportunity to strategize therapeutically against this pathogen. We have previously demonstrated that
Externí odkaz:
https://doaj.org/article/bba175b549eb4c239cf95aa34c11cc84
Autor:
Chandrasekaran Komalapriya, Despoina Kaloriti, Anna T Tillmann, Zhikang Yin, Carmen Herrero-de-Dios, Mette D Jacobsen, Rodrigo C Belmonte, Gary Cameron, Ken Haynes, Celso Grebogi, Alessandro P S de Moura, Neil A R Gow, Marco Thiel, Janet Quinn, Alistair J P Brown, M Carmen Romano
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137750 (2015)
The major fungal pathogen of humans, Candida albicans, mounts robust responses to oxidative stress that are critical for its virulence. These responses counteract the reactive oxygen species (ROS) that are generated by host immune cells in an attempt
Externí odkaz:
https://doaj.org/article/ad4074c400ff483fa22e379c89455593
Autor:
Linda M Holland, Markus S Schröder, Siobhán A Turner, Heather Taff, David Andes, Zsuzsanna Grózer, Attila Gácser, Lauren Ames, Ken Haynes, Desmond G Higgins, Geraldine Butler
Publikováno v:
PLoS Pathogens, Vol 10, Iss 9, p e1004365 (2014)
Candida parapsilosis and Candida albicans are human fungal pathogens that belong to the CTG clade in the Saccharomycotina. In contrast to C. albicans, relatively little is known about the virulence properties of C. parapsilosis, a pathogen particular
Externí odkaz:
https://doaj.org/article/3f68ffb676e241c89cf6b656426d8b49
Autor:
Despoina Kaloriti, Mette Jacobsen, Zhikang Yin, Miranda Patterson, Anna Tillmann, Deborah A. Smith, Emily Cook, Tao You, Melissa J. Grimm, Iryna Bohovych, Celso Grebogi, Brahm H. Segal, Neil A. R. Gow, Ken Haynes, Janet Quinn, Alistair J. P. Brown
Publikováno v:
mBio, Vol 5, Iss 4 (2014)
ABSTRACT Immune cells exploit reactive oxygen species (ROS) and cationic fluxes to kill microbial pathogens, such as the fungus Candida albicans. Yet, C. albicans is resistant to these stresses in vitro. Therefore, what accounts for the potent antifu
Externí odkaz:
https://doaj.org/article/4dfb09531b17429f9de94c33d6f04296