Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ken H. Loh"'
Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5
Autor:
Yanran Chen, Haomiao Su, Jianing Zhao, Zhenkun Na, Kevin Jiang, Antonella Bacchiocchi, Ken H. Loh, Ruth Halaban, Zhentian Wang, Xiongwen Cao, Sarah A. Slavoff
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113145- (2023)
Summary: The conserved WD40-repeat protein WDR5 interacts with multiple proteins both inside and outside the nucleus. However, it is currently unclear whether and how the distribution of WDR5 between complexes is regulated. Here, we show that an unan
Externí odkaz:
https://doaj.org/article/677a2dd973a34f00ba7e7ac83d8ed9a4
Publikováno v:
PLoS ONE, Vol 8, Iss 4 (2013)
Externí odkaz:
https://doaj.org/article/4f211e253af542a687b0ed6d3b3fd67d
Publikováno v:
Biochemical Society Transactions.
Thousands of unannotated small and alternative open reading frames (smORFs and alt-ORFs, respectively) have recently been revealed in mammalian genomes. While hundreds of mammalian smORF- and alt-ORF-encoded proteins (SEPs and alt-proteins, respectiv
Autor:
Xiaofei Yu, Kamal Rahmouni, Jeffrey M. Friedman, Michelle Ka Yan Wu, Paul Cohen, Jingyi Chi, Damian Kim, Marc Schneeberger, Christin Kosse, Ken H. Loh, Donald A. Morgan, Putianqi Wang
Publikováno v:
Nature. 583:839-844
Mutations in the leptin gene (ob) result in a metabolic disorder that includes severe obesity1, and defects in thermogenesis2 and lipolysis3, both of which are adipose tissue functions regulated by the sympathetic nervous system. However, the basis o
Autor:
Yanran Chen, Xiongwen Cao, Haomiao Su, Zhenkun Na, Kevin Jiang, Antonella Bacchiocchi, Ken H. Loh, Ruth Halaban, Sarah Slavoff
Publikováno v:
SSRN Electronic Journal.
Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID
Autor:
Zhenkun Na, Xiaoyun Dai, Shu-Jian Zheng, Carson J. Bryant, Ken H. Loh, Haomiao Su, Yang Luo, Amber F. Buhagiar, Xiongwen Cao, Susan J. Baserga, Sidi Chen, Sarah A. Slavoff
Publikováno v:
Molecular cell. 82(15)
Proteogenomic identification of translated small open reading frames has revealed thousands of previously unannotated, largely uncharacterized microproteins, or polypeptides of less than 100 amino acids, and alternative proteins (alt-proteins) that a
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e52823 (2013)
Neurexin and neuroligin are transmembrane adhesion proteins that play an important role in organizing the neuronal synaptic cleft. Our lab previously reported a method for imaging the trans-synaptic binding of neurexin and neuroligin called BLINC (Bi
Externí odkaz:
https://doaj.org/article/8fae4331ef92423a923c135702d53ee9
Autor:
Alan Saghatelian, Jens Lykke-Andersen, Bogdan Budnik, Sarah A. Slavoff, Jiao Ma, Nadia G. D'Lima, Ken H Loh, Lauren Winkler, Qian Chu, Elizabeth O. Corpuz
Publikováno v:
Nature chemical biology
Nature chemical biology, vol 13, iss 2
Nature chemical biology, vol 13, iss 2
Proteomic detection of non-annotated microproteins indicates the translation of hundreds of small open reading frames (smORFs) in human cells, but whether these microproteins are functional or not is unknown. Here, we report the discovery and charact
Autor:
Putianqi, Wang, Ken H, Loh, Michelle, Wu, Donald A, Morgan, Marc, Schneeberger, Xiaofei, Yu, Jingyi, Chi, Christin, Kosse, Damian, Kim, Kamal, Rahmouni, Paul, Cohen, Jeffrey, Friedman
Publikováno v:
Nature. 583(7818)
Mutations in the leptin gene (ob) result in a metabolic disorder that includes severe obesity
Autor:
Steven A. Carr, Alice Y. Ting, Kurt James Cox, Stephanie S Lam, Namrata D. Udeshi, Victoria Hung, Kayvon Pedram, Ken H. Loh
Publikováno v:
Nature Protocols. 11:456-475
This protocol describes a method to obtain spatially resolved proteomic maps of specific compartments within living mammalian cells. An engineered peroxidase, APEX2, is genetically targeted to a cellular region of interest. Upon the addition of hydro