Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Ken Grime"'
Epithelial senescence in idiopathic pulmonary fibrosis is propagated by small extracellular vesicles
Autor:
Sabha Asghar, Susan Monkley, David J. F. Smith, Richard J. Hewitt, Ken Grime, Lynne A. Murray, Catherine L. Overed-Sayer, Philip L. Molyneaux
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease that affects 3 million people worldwide. Senescence and small extracellular vesicles (sEVs) have been implicated in the pathogenesis of IPF, although how sEVs promote d
Externí odkaz:
https://doaj.org/article/454012ad2e384074825f22792ab6bd66
Autor:
Zsolt Cselényi, Aurelija Jucaite, Cecilia Kristensson, Per Stenkrona, Pär Ewing, Andrea Varrone, Peter Johnström, Magnus Schou, Ana Vazquez-Romero, Mohammad Mahdi Moein, Martin Bolin, Jonathan Siikanen, Pär Grybäck, Bengt Larsson, Christer Halldin, Ken Grime, Ulf G. Eriksson, Lars Farde
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Background The radioligand [11C]VC-002 was introduced in a small initial study long ago for imaging of muscarinic acetylcholine receptors (mAChRs) in human lungs using positron emission tomography (PET). The objectives of the present study i
Externí odkaz:
https://doaj.org/article/b57a1b395ada441a9bd3f59c5762420f
Autor:
Zsolt Cselényi, Aurelija Jucaite, Pär Ewing, Per Stenkrona, Cecilia Kristensson, Peter Johnström, Magnus Schou, Martin Bolin, Christer Halldin, Bengt Larsson, Ken Grime, Ulf G Eriksson, Lars Farde
Publikováno v:
Frontiers in Nuclear Medicine. 2
IntroductionMolecular imaging has not been used to support the development of drugs for the treatment of pulmonary disorders. The aim of the present translational study was to advance quantitative pulmonary PET imaging by demonstrating occupancy of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea583135b96ecff5a1cbdb54e1b7bc5c
Autor:
Marie Brännström, Pär Nordell, Britta Bonn, Andrew M. Davis, Anna-Pia Palmgren, Constanze Hilgendorf, Katarina Rubin, Ken Grime
Publikováno v:
Pharmaceutics, Vol 7, Iss 4, Pp 554-564 (2015)
Clinical studies with montelukast show variability in effect and polymorphic OATP2B1-dependent absorption has previously been implicated as a possible cause. This claim has been challenged with conflicting data and here we used OATP2B1-transfected HE
Externí odkaz:
https://doaj.org/article/b7ecb137ad394c7fbfe6e98e03d50658
Autor:
Katarina Rubin, Pär Ewing, Erica Bäckström, Anna Abrahamsson, Britta Bonn, Satoshi Kamata, Ken Grime
Publikováno v:
Pharmaceutics, Vol 12, Iss 2, p 117 (2020)
Significant pulmonary metabolism of inhaled drugs could have drug safety implications or influence pharmacological effectiveness. To study this in vitro, lung microsomes or S9 are often employed. Here, we have determined if rat and human lung microso
Externí odkaz:
https://doaj.org/article/d9f41588b5484a3aa377d159bf1c044e
Autor:
Per Stenkrona, Zsolt Cselényi, Peter Johnström, Ken Grime, Jonathan Siikanen, Ulf Eriksson, Lars Farde, Aurelija Jucaite, Bengt Larsson, Martin Bolin, Cecilia Kristensson, Mohammad Mahdi Moein, Ana Vazquez-Romero, Andrea Varrone, Christer Halldin, Magnus Schou, Pär Ewing, Pär Grybäck
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-13 (2020)
Background The radioligand [11C]VC-002 was introduced in a small initial study long ago for imaging of muscarinic acetylcholine receptors (mAChRs) in human lungs using positron emission tomography (PET). The objectives of the present study in control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1691388763c3eec3682a1a3e5d0c4b66
http://link.springer.com/article/10.1186/s13550-020-00634-0
http://link.springer.com/article/10.1186/s13550-020-00634-0
Autor:
Gregory Hamm, Richard J. A. Goodwin, Nicole Strittmatter, Markus Fridén, Mikael Brülls, Anna Nilsson, Erica Bäckström, Per E. Andrén, Ken Grime
Publikováno v:
Journal of Aerosol Medicine and Pulmonary Drug Delivery. 33:43-53
Background: For the treatment of respiratory disease, inhaled drug delivery aims to provide direct access to pharmacological target sites while minimizing systemic exposure. Despite this long-held tenet of inhaled therapeutic advantage, there are lim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4629d5b887d7367bd80614bb6bcb406
https://doi.org/10.1089/jamp.2019.1536
https://doi.org/10.1089/jamp.2019.1536
Autor:
Zsolt Cselényi, Aurelija Jucaite, Pär Ewing, Per Stenkrona, Cecilia Kristensson, Peter Johnström, Magnus Schou, Martin Bolin, Christer Halldin, Bengt Larsson, Ken Grime, Ulf G Eriksson, Lars Farde
BackgroundThe aim of the present translational PET study was to estimate occupancy of tiotropium at muscarinic acetylcholine receptors (mAChR) in the lungs in vivo. The relationship between the tiotropium exposure and receptor occupancy (RO) in the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::befe844d14c449eb02b1e1c8fc0f5bfc
https://doi.org/10.21203/rs.3.rs-1336103/v1
https://doi.org/10.21203/rs.3.rs-1336103/v1
Publikováno v:
Drug Metabolism and Disposition. 47:865-873
The low volume of distribution associated with acidic molecules means that clearance (CL) must also be very low to achieve an effective half-life commensurate with once or twice daily dosing. Plasma protein binding (PPB) should not usually be conside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e4bc31890fef9bc406383265444c83
https://doi.org/10.1124/dmd.119.087163
https://doi.org/10.1124/dmd.119.087163
Autor:
Markus Fridén, Ken Grime, Teodor Erngren, Lina Odqvist, Walter Lindberg, Erica Bäckström, Britt-Marie Fihn
Publikováno v:
Airway pharmacology and treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcc0fe4781bba3df532e5dd5250026ae
https://doi.org/10.1183/13993003.congress-2020.1417
https://doi.org/10.1183/13993003.congress-2020.1417