Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Ken Fujise"'
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102903- (2023)
Astrocytes affect stroke outcomes by acquiring functionally dominant phenotypes. Understanding molecular mechanisms dictating astrocyte functional status after brain ischemia/reperfusion may reveal new therapeutic strategies. Adenosine deaminase acti
Externí odkaz:
https://doaj.org/article/a59b2061d0224badb14f8862fe26c1c8
Autor:
Decha Pinkaew, Erik Martinez-Hackert, Wei Jia, Matthew D. King, Fei Miao, Nicole R. Enger, Runglawan Silakit, Kota Ramana, Shi-You Chen, Ken Fujise
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Fortilin prevents the activation of the TGF-β1 receptor by occupying the pocket of TGF-β1 and competing with TGF-βRII to bind with TGF-β1. This inhibits Smad3 phosphorylation and the differentiation of C3H10T1/2 mesenchymal progenitor cells to sm
Externí odkaz:
https://doaj.org/article/5e135eec35ad4b54abfbb03df6f53892
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Heart failure (HF) has reached epidemic proportions in developed countries, affecting over 20 million people worldwide. Despite modern medical and device therapies, 60–70% of HF patients still die within 5 years of diagnosis as it relentle
Externí odkaz:
https://doaj.org/article/f9992a0e71944714947dfcccc820b5a8
Autor:
Ayman Elbadawi, Ahmed H. Mohamed, Islam Y. Elgendy, Gbolahan O. Ogunbayo, Michael Megaly, Hend I. Shahin, Karim Mahmoud, Mohamed A. Omer, Ahmed Abuzaid, Ken Fujise, Syed Gilani
Publikováno v:
Cardiology and Therapy, Vol 9, Iss 1, Pp 107-118 (2019)
Abstract Introduction The outcomes of transfemoral (TF) compared with transapical (TA) access for transcatheter aortic valve replacement (TAVR) in diabetics are unknown. Methods We queried the NIS database (2011–2014) to identify diabetics who unde
Externí odkaz:
https://doaj.org/article/6a14decfa43f45b6af4d415719c2c5e4
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8751 (2022)
Inflammatory bowel disease (IBD), classified primarily between Crohn’s disease and ulcerative colitis, is a collection of chronic gastrointestinal inflammatory conditions that cause multiple complications because of systemic alterations in the immu
Externí odkaz:
https://doaj.org/article/6554dd8a6b4b42dea82f8f2f7c475686
Autor:
Decha Pinkaew, Abhijnan Chattopadhyay, Matthew D. King, Preedakorn Chunhacha, Zhihe Liu, Heather L. Stevenson, Yanjie Chen, Patuma Sinthujaroen, Owen M. McDougal, Ken Fujise
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
IRE1α is an ER stress sensor, whose activity induces apoptosis. Here, the authors report that fortilin, a pro-survival factor, with yet unknown roles in ER stress, interacts with active IRE1α, inhibits both its kinase end RNase activities, and prot
Externí odkaz:
https://doaj.org/article/41562ffacfaf46d09359e93528290463
Autor:
Hasseri Halim, Decha Pinkaew, Preedakorn Chunhacha, Patuma Sinthujaroen, Perumal Thiagarajan, Ken Fujise
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218934 (2019)
Ticagrelor (TIC), a P2Y purinoceptor 12 (P2Y12)-receptor antagonist, has been widely used to treat patients with acute coronary syndrome. Although animal studies suggest that TIC protects against atherosclerosis, it remains unknown whether it does so
Externí odkaz:
https://doaj.org/article/14a23a02040d488ca3aded95e11faaa5
Publikováno v:
Case Reports in Pulmonology, Vol 2017 (2017)
Dyspnea accounts for more than one-fourth of the hospital admissions from Emergency Department. Chronic conditions such as Chronic Obstructive Pulmonary Disease, Congestive Heart Failure, and Asthma are being common etiologies. Less common etiologies
Externí odkaz:
https://doaj.org/article/4cf107193af64b19a5abaaa20318fc96
Autor:
Decha Pinkaew, Erik Martinez-Hackert, Wei Jia, Matthew King, Fei Miao, Nicole Enger, Runglawan Silakit, Kota Ramana, Shiyou Chen, Ken Fujise
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Fortilin is a 172-amino acid multifunctional protein present in both intra- and extracellular spaces. Although fortilin binds and regulates various cellular proteins, the biological role of extracellular fortilin remains unknown. Here we report that
Autor:
Neal L. Weintraub, Andra L. Blomkalns, Mourad Ogbi, Tetsuo Horimatsu, Tyler W. Benson, Yuqing Huo, David J. Fulton, Gautam Agarwal, Richard Lee, Michael A. Winkler, Lufei Young, Ken Fujise, Avirup Guha, Tohru Fukai, Masuko Ushio-Fukai, Xiaochun Long, Brian H. Annex, Ha Won Kim
Publikováno v:
Clinical science (London, England : 1979). 136(5)
Prostaglandin D2 (PGD2) released from immune cells or other cell types activates its receptors, D prostanoid receptor (DP)1 and 2 (DP1 and DP2), to promote inflammatory responses in allergic and lung diseases. Prostaglandin-mediated inflammation may