Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Ken Fujimura"'
Autor:
Carina Mucciolo Melo, Huawei Wang, Ken Fujimura, Jan Strnadel, Maria Cecília Zorél Meneghetti, Helena Bonciani Nader, Richard L. Klemke, Maria Aparecida Silva Pinhal
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Angiogenesis is the formation of new vessels from pre-existing vasculature. The heparan sulfate chains from endothelial cell proteoglycans interact with the major angiogenic factors, regulating blood vessels´ formation. Since the FDA´s first approv
Externí odkaz:
https://doaj.org/article/6919d55cbf844803a474e69767b05b14
Publikováno v:
Bio-Protocol, Vol 8, Iss 11 (2018)
Traditional 2D cell cultures with cells grown as monolayers on solid surface still represent the standard method in cancer research for drug testing. Cells grown in 2D cultures, however, lack relevant cell-matrix and cell-cell interactions and ignore
Externí odkaz:
https://doaj.org/article/de945f6b0209443ab98ec54fb5d11048
Autor:
Richard L. Klemke, Kun-Liang Guan, Michael Bouvet, Jonathan Kelber, Jack Bui, Hyun Woo Park, Carlos Peinado, Emilie Gross, Tracy Wright, Meghan Wyse, Wei Zhang, Huawei Wang, Ken Fujimura, Sunkyu Choi, Jan Strnadel
Western blots showing PEAk1 and YAP1 depletion in PDAC cells treated with two independent shRNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0f445e75946f135bed5bdbe2a81297
https://doi.org/10.1158/0008-5472.22417251.v1
https://doi.org/10.1158/0008-5472.22417251.v1
Schematic of proposed working model for feedback regulation of KRas expression in PDAC cells by eIF5A-PEAK1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fd3a3051cab7a579069ca16824ed1f
https://doi.org/10.1158/0008-5472.22421633
https://doi.org/10.1158/0008-5472.22421633
Schematic showing hypusination of lysine 50 of eIF5A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff09c05e202c30bfefa733e902bfcd3
https://doi.org/10.1158/0008-5472.22421642.v1
https://doi.org/10.1158/0008-5472.22421642.v1
There remains intense interest in tractable approaches to target or silence the KRAS oncoprotein as a rational therapeutic strategy to attack pancreatic ductal adenocarcinoma (PDAC) and other cancers that overexpress it. Here we provide evidence that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::434a04c38b34f5bf3a016b4feb1fc09f
https://doi.org/10.1158/0008-5472.c.6510977.v1
https://doi.org/10.1158/0008-5472.c.6510977.v1
Autor:
Richard L. Klemke, Kun-Liang Guan, Michael Bouvet, Jonathan Kelber, Jack Bui, Hyun Woo Park, Carlos Peinado, Emilie Gross, Tracy Wright, Meghan Wyse, Wei Zhang, Huawei Wang, Ken Fujimura, Sunkyu Choi, Jan Strnadel
List of PEAK1 regulated proteins involved in cytoskeleton organization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0f71c5dba35f3698ea90e0ce25e167
https://doi.org/10.1158/0008-5472.22417242.v1
https://doi.org/10.1158/0008-5472.22417242.v1
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d7b207d4d15df0cc34ada201d3c0eab
https://doi.org/10.1158/0008-5472.22421645
https://doi.org/10.1158/0008-5472.22421645
Pharmacological perturbation of glutamine metabolism and eIF5A inhibit cancer cell growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ed79e7a98f9ded08db698efa5e47a4
https://doi.org/10.1158/0008-5472.22421630.v1
https://doi.org/10.1158/0008-5472.22421630.v1
Targeting eIF5A inhibits KRas expression and PDAC cell growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133e608e04358a6250bc1c526444012f
https://doi.org/10.1158/0008-5472.22421639
https://doi.org/10.1158/0008-5472.22421639