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Autor:
Katherine Young, Georgianna Harris, Lynn L. Silver, Gayle E. Taylor, Ken Ellsworth, Amjad Ali, Ronald E. Painter
Publikováno v:
Journal of medicinal chemistry. 46(10)
6-Anilinopyrazolo[3,4-d]pyrimidin-4-ones are novel dGTP analogues that inhibit the replication-specific enzyme DNA polymerase III (DNA pol III) of Staphlococcus aureus and other Gram-positive (Gr+) bacteria. To enhance the potential of these inhibito