Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Ken E. Starbuck"'
Autor:
P.M.D. Fitzgerald, Joel R. Huff, Ken E. Starbuck, L.J. Chen, Hungate Randall W, Paul L. Darke, P. S. Anderson, M. K. Holloway, J. P. Vacca
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:499-504
The synsthesis and structure activity relationships of conformationally constrained analogs of the HIV-1 protease inhibitor L-685,434 are described. In addition, the X-ray crystal structure of a complex between L-700,497 and the HIV-1 protease is sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de8a47cac47dcdde2e49870c8cae019d
https://doi.org/10.1016/0960-894x(94)80025-1
https://doi.org/10.1016/0960-894x(94)80025-1
Autor:
Bruce D. Dorsey, Emilio A. Emini, M. Katharine Holloway, Joan A. Zugay, P. S. Anderson, J. H. Lin, J. L. Chen, Joel R. Huff, James P. Guare, Ken E. Starbuck, Willie Whitter, Stacey L. McDaniel, Hungate Randall W, I.-W. Chen, William A. Schleif, Joseph P. Vacca, Paul L. Darke, Quintero Julio C, Rhonda B. Levin
Publikováno v:
Bioorganicmedicinal chemistry. 2(9)
Incorporation of a γ-lactam in hydroxyethylene isosteres results in modest inhibitors of HIV-1 protease. Additional structural activity studies have produced significantly more potent inhibitors with the introduction of the trisubstituted cyclopenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7236b327f4e6bd0af85bd95d3a3154bf
https://pubmed.ncbi.nlm.nih.gov/7712123
https://pubmed.ncbi.nlm.nih.gov/7712123