Zobrazeno 1 - 10
of 1 703
pro vyhledávání: '"Ken CHEN"'
Autor:
Sarina A. Piha-Paul, Chieh Tseng, Cheuk Hong Leung, Ying Yuan, Daniel D. Karp, Vivek Subbiah, David Hong, Siqing Fu, Aung Naing, Jordi Rodon, Milind Javle, Jaffer A. Ajani, Kanwal P. Raghav, Neeta Somaiah, Gordon B. Mills, Apostolia M. Tsimberidou, Xiaofeng Zheng, Ken Chen, Funda Meric-Bernstam
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Cancer cells with BRCA1/2 deficiencies are sensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. We evaluated the efficacy of talazoparib in DNA-Damage Repair (DDR)-altered patients. In this phase II trial, patients were enrolled onto
Externí odkaz:
https://doaj.org/article/1e0d0ae9bd434d9dbecfece7f428357b
Autor:
Sunita Keshari, Alexander S. Shavkunov, Qi Miao, Akata Saha, Tomoyuki Minowa, Martina Molgora, Charmelle D. Williams, Mehdi Chaib, Anna M. Highsmith, Josué E. Pineda, Sayan Alekseev, Elise Alspach, Kenneth H. Hu, Marco Colonna, Kristen E. Pauken, Ken Chen, Matthew M. Gubin
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114875- (2024)
Summary: The goal of therapeutic cancer vaccines and immune checkpoint therapy (ICT) is to promote T cells with anti-tumor capabilities. Here, we compared mutant neoantigen (neoAg) peptide-based vaccines with ICT in preclinical models. NeoAg vaccines
Externí odkaz:
https://doaj.org/article/eb47593abbe54523acb581af90620b62
Publikováno v:
Advanced Science, Vol 11, Iss 38, Pp n/a-n/a (2024)
Abstract Acute kidney injury (AKI) is the sudden decrease in renal function that can be attributed to dysregulated reactive oxygen species (ROS) production and impaired mitochondrial function. Irisin, a type I membrane protein secreted by skeletal mu
Externí odkaz:
https://doaj.org/article/bc7a1eb71e084835b6b3a4afc7a377e4
Autor:
Yuan-juan Tang, Zhen Zhang, Tong Yan, Ken Chen, Guo-fan Xu, Shi-qiang Xiong, Dai-qian Wu, Jie Chen, Pedro A. Jose, Chun-yu Zeng, Jin-juan Fu
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-19 (2024)
Abstract Background Diabetic cardiomyopathy (DCM) is a serious complication in patients with type 1 diabetes mellitus (T1DM), which still lacks adequate therapy. Irisin, a cleavage peptide off fibronectin type III domain-containing 5, has been shown
Externí odkaz:
https://doaj.org/article/5982b494ad0241788d7941b784c93025
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-8 (2024)
Abstract Clustering and visualization are essential parts of single-cell gene expression data analysis. The Euclidean distance used in most distance-based methods is not optimal. The batch effect, i.e., the variability among samples gathered from dif
Externí odkaz:
https://doaj.org/article/622967bd5211402ea382aaa6e8f828d1
Autor:
Jiakai Hou, Yanjun Wei, Jing Zou, Roshni Jaffery, Long Sun, Shaoheng Liang, Ningbo Zheng, Ashley M. Guerrero, Nicholas A. Egan, Ritu Bohat, Si Chen, Caishang Zheng, Xiaobo Mao, S. Stephen Yi, Ken Chen, Daniel J. McGrail, Nidhi Sahni, Pei-Yong Shi, Yiwen Chen, Xuping Xie, Weiyi Peng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Host anti-viral factors are essential for controlling SARS-CoV-2 infection but remain largely unknown due to the biases of previous large-scale studies toward pro-viral host factors. To fill in this knowledge gap, we perform a genome-wide CR
Externí odkaz:
https://doaj.org/article/40cc73e86a42414c8dbcd229f50f5fe6
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Traffic time series anomaly detection has been intensively studied for years because of its potential applications in intelligent transportation. However, classical traffic anomaly detection methods often overlook the evolving dynamic associ
Externí odkaz:
https://doaj.org/article/2e41df57b73e4ace8b3d4da03250a356
Autor:
Kang Li, Guoge Zhang, Ken Chen, Wenfang Li, Zhisheng Zhu, Yi Huang, Wen Zhu, Zhongmiao Liao, Bingbing Wan, Jun Liang, Jiajing Yang, Rujian Liang, Yuandong Liu
Publikováno v:
Journal of Materials Research and Technology, Vol 28, Iss , Pp 3597-3608 (2024)
In this study, the pure Al and binary Al–Ni alloys with Ni addition of 1, 3, 6, and 10 wt % were coated via micro arc oxidation (MAO) in a tetraborate and phosphate based electrolyte for 60 min. With increased Ni content, the color of MAO coating b
Externí odkaz:
https://doaj.org/article/4a7be7bd9ec1498483ebaac0ce6e047f
Autor:
Shan He, Matthew M. Gubin, Hind Rafei, Rafet Basar, Merve Dede, Xianli Jiang, Qingnan Liang, Yukun Tan, Kunhee Kim, Maura L. Gillison, Katayoun Rezvani, Weiyi Peng, Cara Haymaker, Sharia Hernandez, Luisa M. Solis, Vakul Mohanty, Ken Chen
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110096- (2024)
Summary: Recent developments in immunotherapy, including immune checkpoint blockade (ICB) and adoptive cell therapy (ACT), have encountered challenges such as immune-related adverse events and resistance, especially in solid tumors. To advance the fi
Externí odkaz:
https://doaj.org/article/857a54432adf43e68098a98661073bd8
Autor:
Litao Tang, Bin Lyu, Dangge Gao, Yingying Zhou, Yunchuan Wang, Fangxing Wang, Zhangting Jia, Yatong Fu, Ken Chen, Jianzhong Ma
Publikováno v:
Advanced Science, Vol 11, Iss 21, Pp n/a-n/a (2024)
Abstract The development of functional textiles combining conventional apparel with advanced technologies for personal health management (PHM) has garnered widespread attention. However, the current PHM textiles often achieve multifunctionality by st
Externí odkaz:
https://doaj.org/article/834caa6ad61e4acfbddabd8e1d4db5e8