Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ken C. Walls"'
Autor:
David Baglietto-Vargas, Stefania Forner, Lena Cai, Alessandra C. Martini, Laura Trujillo-Estrada, Vivek Swarup, Marie Minh Thu Nguyen, Kelly Do Huynh, Dominic I. Javonillo, Kristine Minh Tran, Jimmy Phan, Shan Jiang, Enikö A. Kramár, Cristina Nuñez-Diaz, Gabriela Balderrama-Gutierrez, Franklin Garcia, Jessica Childs, Carlos J. Rodriguez-Ortiz, Juan Antonio Garcia-Leon, Masashi Kitazawa, Mohammad Shahnawaz, Dina P. Matheos, Xinyi Ma, Celia Da Cunha, Ken C. Walls, Rahasson R. Ager, Claudio Soto, Antonia Gutierrez, Ines Moreno-Gonzalez, Ali Mortazavi, Andrea J. Tenner, Grant R. MacGregor, Marcelo Wood, Kim N. Green, Frank M. LaFerla
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Most instances of Alzheimer’s disease (AD) are sporadic or not associated with a particular mutation. Here, the authors develop knock-in mice that express wildtype human Aβ under control of the mouse App locus, which may have potential for modelli
Externí odkaz:
https://doaj.org/article/1e311a8bbdd34a96bb987b252f4dfaaf
Autor:
Matthew A. Powell, Tim Hui-Ming Huang, Pearlly S. Yan, David G. Mutch, Mary Ann Mallon, Ken C. Walls, Amy P. Schmidt, Paul J. Goodfellow, Israel Zighelboim
Purpose: To identify novel endometrial cancer-specific methylation markers and to determine their association with clinicopathologic variables and survival outcomes.Experimental Design: Differential methylation hybridization analysis (DMH) was done f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d68d776bd0effffe69a9aae67d3e599
https://doi.org/10.1158/1078-0432.c.6518314.v1
https://doi.org/10.1158/1078-0432.c.6518314.v1
Autor:
Alessandra C. Martini, Kristine Minh Tran, Kelly Do Huynh, Cristina Nuñez-Diaz, Franklin Garcia, Celia da Cunha, Kim N. Green, Andrea J. Tenner, Rahasson R. Ager, Stefania Forner, David Baglietto-Vargas, Dina P. Matheos, Marcelo A. Wood, Carlos J. Rodriguez-Ortiz, Laura Trujillo-Estrada, Frank M. LaFerla, Enikö A. Kramár, Jimmy Phan, Xinyi Ma, Claudio Soto, Ines Moreno-Gonzalez, Grant R. MacGregor, Vivek Swarup, Juan Antonio García-León, Lena Cai, Masashi Kitazawa, Dominic I. Javonillo, Mohammad Shahnawaz, Jessica E. Childs, Antonia Gutierrez, Ali Mortazavi, Shan Jiang, Marie Minh Thu Nguyen, Gabriela Balderrama-Gutierrez, Ken C. Walls
Publikováno v:
Nature Communications
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The majority of Alzheimer’s disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant forms of the disease. H
Autor:
Kathleen C. Baysac, Krikor Dikranian, Ken C. Walls, Heather M. Christensen, John W. Olney, Kevin A. Roth, David A. Harris, Aimin Li
Publikováno v:
The American Journal of Pathology. 176:2695-2706
Several different deletions within the N-terminal tail of the prion protein (PrP) induce massive neuronal death when expressed in transgenic mice. This toxicity is dose-dependently suppressed by coexpression of full-length PrP, suggesting that it res
Autor:
Ken C. Walls, Kevin A. Roth, Arindam P. Ghosh, John J. Shacka, Barbara J. Klocke, Jianhua Zhang, Mary E. Ballestas, Aimee V. Franklin
Publikováno v:
Journal of Biological Chemistry. 285:10497-10507
Macroautophagy (autophagy) is a process wherein bulk cytosolic proteins and damaged organelles are sequestered and degraded via the lysosome. Alterations in autophagy-associated proteins have been shown to cause neural tube closure defects, neurodege
Autor:
Ying Geng, Rizwan S. Akhtar, Arindam P. Ghosh, Ken C. Walls, Barbara J. Klocke, Kevin A. Roth
Publikováno v:
Journal of Histochemistry & Cytochemistry. 58:265-275
The prodeath effects of p53 are typically mediated via its transcriptional upregulation of proapoptotic Bcl-2 family members, including PUMA, Noxa, and/or Bax. We previously reported that staurosporine (STS), a broad-spectrum kinase inhibitor and pro
Autor:
Barbara J. Klocke, Kevin A. Roth, Andreas Strasser, Arindam P. Ghosh, Rune Toms, Ken C. Walls
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 68:747-756
Synaptogenesis in humans occurs in the last trimester of gestation and in the first few years of life, whereas it occurs in the postnatal period in rodents. A single exposure of neonatal rodents to ethanol during this period evokes extensive neuronal
Autor:
Amy P. Schmidt, Ken C. Walls, David G. Mutch, Israel Zighelboim, Matthew A. Powell, Mary Ann Mallon, Pearlly S. Yan, Tim H M Huang, Paul J. Goodfellow
Publikováno v:
Clinical Cancer Research. 13:2882-2889
Purpose: To identify novel endometrial cancer-specific methylation markers and to determine their association with clinicopathologic variables and survival outcomes.Experimental Design: Differential methylation hybridization analysis (DMH) was done f
Autor:
Paul J. Goodfellow, Ming Yu Fan, Katherine Y. Look, Elizabeth M. Swisher, Randall K. Gibb, Thomas J. Herzog, David G. Mutch, Barbara M. Buttin, Ken C. Walls, Janet S. Rader
Publikováno v:
Proceedings of the National Academy of Sciences. 100:5908-5913
Endometrial cancer is the most common gynecologic malignancy in the United States and the most frequent extracolonic tumor in hereditary nonpolyposis colorectal cancer (HNPCC). HNPCC patients have inherited defects in DNA mismatch repair and the micr
Autor:
Dave Cheng, Frank M. LaFerla, Rodrigo Medeiros, Vitaly Vasilevko, Rahasson R. Ager, Ken C. Walls
Alzheimer's disease (AD) is a proteinopathy characterized by the accumulation of β-amyloid (Aβ) and tau. To date, clinical trials indicate that Aβ immunotherapy does not improve cognition. Consequently, it is critical to modulate other aspects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a1eef1d3d9c78731063374f69117d6
https://europepmc.org/articles/PMC4437620/
https://europepmc.org/articles/PMC4437620/