Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ken Boakye"'
Autor:
Sandra Santulli-Marotto, Ken Boakye, Eilyn Lacy, Sheng-Jiun Wu, Jennifer Luongo, Karl Kavalkovich, Ana Coelho, Cory M Hogaboam, Mary Ryan
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81465 (2013)
CCL17 (TARC) function can be completely abolished by mAbs that block either one of two distinct sites required for CCR4 signaling. This chemokine is elevated in sera of asthma patients and is responsible for establishing inflammatory sites through CC
Externí odkaz:
https://doaj.org/article/5113c4a64a82451fa5aa82a94e39f868
Autor:
Haiyan Jiang, Judy Connor, Peter Haytko, Ken Boakye, Suparna Paul, Mark L. Chiu, Tom C. Nesspor
Publikováno v:
Protein Expression and Purification. 121:133-140
Bispecific antibody generation is actively pursued for therapeutic and research antibody development. Although there are multiple strategies for generating bispecific antibodies (bsAbs); the common challenge is to develop a scalable method to prepare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707d2527cad2b917ad8e42cc791ed86e
https://doi.org/10.1016/j.pep.2016.01.014
https://doi.org/10.1016/j.pep.2016.01.014
Autor:
Sheri Moores, Eilyn R. Lacy, Jose Pardinas, Manuel A. Sepulveda, Ken Boakye, Mark L. Chiu, Barbara Bushey, Renouard Sanders, Stephen Jarantow
Publikováno v:
The Journal of Biological Chemistry
Background: Cancer cells express surface antigens at different levels from normal cells. Results: Differences in EGFR and c-MET receptor density levels influenced the in vitro activity of an EGFR × c-MET bispecific antibody. Conclusion: Consideratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0783529e37128297c7e245bbb9ec90
https://doi.org/10.1074/jbc.m115.651653
https://doi.org/10.1074/jbc.m115.651653
Autor:
Ana Coelho, Tadas Panavas, Bingyuan Wu, Theodore Petley, Lester Gutshall, Jamie Fisher, Sandra Santulli-Marotto, Ken Boakye, Michael A. Rycyzyn, Cory M. Hogaboam, Jennifer L. Luongo, Karl Kavalkovich, Mary Ryan
Publikováno v:
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 32:162-171
The chemokines CCL17 (TARC) and CCL22 (MDC) function through the same receptor, CCR4, but have been proposed to differentially affect the immune response. To better understand the role of the individual ligands, a panel of rat anti-mouse CCL17 surrog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a2aa625f0098fb6e95e7535f408276
https://doi.org/10.1089/mab.2012.0112
https://doi.org/10.1089/mab.2012.0112
Autor:
Sheng-Jiun Wu, Sandra Santulli-Marotto, John Wheeler, Jennifer L. Luongo, Eilyn R. Lacy, Ken Boakye, Mary Ryan
Publikováno v:
Monoclonal antibodies in immunodiagnosis and immunotherapy. 34(6)
CCL22 inactivation in vivo occurs by cleavage at the N-terminus; however, it is unclear whether this encompasses the entire site of CCR4 interaction. CCL17 also binds CCR4 and its function requires binding via two discrete binding sites. Using monocl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55538ab8af79020e6f34671585cd63c
https://pubmed.ncbi.nlm.nih.gov/26683175
https://pubmed.ncbi.nlm.nih.gov/26683175
Autor:
Jeffrey Shapiro, Bullock William H, Christine Keiper, Manami Tsutsumi, Ling Yang, Roger B Clark, Xin Ma, Sidney X. Liang, James N. Livingston, Louis-David Cantin, Christiana Iwuagwu, Frederick Ehrgott, Jeffrey Johnson, Thomas H. Claus, Ken Boakye, Herbert Ogutu, Christopher Town, Michael Burns, Michelle Daly, Robert Schoenleber, Fernando E. delaCruz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1056-1061
Modulation of PPAR activities represents an attractive approach for the treatment of diabetes with associated cardiovascular complications. The indanylacetic acid structural motif has proven useful in the generation of potent and tunable PPAR ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9a4acbce2e5d8ca51dd1dff7df78ef5
https://doi.org/10.1016/j.bmcl.2006.11.025
https://doi.org/10.1016/j.bmcl.2006.11.025
Autor:
Eilyn R. Lacy, Ken Boakye, Brian Whitaker, John Kehoe, Deidra Bethea, Mary Ryan, Feng Yiqing, Sandra Santulli-Marotto, John Wheeler
Publikováno v:
Protein engineering, designselection : PEDS. 27(6)
CCL17 is a homeostatic chemokine associated with several human inflammatory pathologies. This makes CCL17 a potential point of intervention in inflammatory diseases. Using a Fab-pIX phage display system we were able to select antibodies that specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7295b1b5b8ddf7dfb79dddd925f151ad
https://pubmed.ncbi.nlm.nih.gov/24742503
https://pubmed.ncbi.nlm.nih.gov/24742503
Autor:
Ana Lucia Coelho, Jennifer L. Luongo, Mary Ryan, Sheng-Jiun Wu, Ken Boakye, Eilyn R. Lacy, Sandra Santulli-Marotto, Cory M. Hogaboam, Karl Kavalkovich
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 12, p e81465 (2013)
PLoS ONE, Vol 8, Iss 12, p e81465 (2013)
CCL17 (TARC) function can be completely abolished by mAbs that block either one of two distinct sites required for CCR4 signaling. This chemokine is elevated in sera of asthma patients and is responsible for establishing inflammatory sites through CC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45772af8e7d4d1174eed875d57762e72
https://pubmed.ncbi.nlm.nih.gov/24339934
https://pubmed.ncbi.nlm.nih.gov/24339934
Autor:
Francis X. Farrell, Bernard Amegadzie, Michael Naso, Bethany Swencki-Underwood, Steve Pomerantz, Joe Vennarini, Jinquan Luo, Mark R. Cunningham, Juliane Mills, Ken Boakye
Publikováno v:
Protein expression and purification. 57(2)
Bone morphogenetic protein-7 (BMP-7, OP-1) is a secreted growth factor that is predominantly known for its osteoinductive properties, though it has also been implicated as having a role in mammalian kidney development. Clinical efficacy of recombinan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be85ee4ea7fadad7acde17ba2189b4c
https://pubmed.ncbi.nlm.nih.gov/17977014
https://pubmed.ncbi.nlm.nih.gov/17977014
Autor:
Louis-David, Cantin, Sidney, Liang, Herbert, Ogutu, Christiana I, Iwuagwu, Ken, Boakye, William H, Bullock, Michael, Burns, Roger, Clark, Thomas, Claus, Fernando E, delaCruz, Michelle, Daly, Frederick J, Ehrgott, Jeffrey S, Johnson, Christine, Keiper, James N, Livingston, Robert W, Schoenleber, Jeffrey, Shapiro, Christopher, Town, Ling, Yang, Manami, Tsutsumi, Xin, Ma
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(4)
Modulation of PPAR activities represents an attractive approach for the treatment of diabetes with associated cardiovascular complications. The indanylacetic acid structural motif has proven useful in the generation of potent and tunable PPAR ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::99a07f1d16456cb08493e57ee48c70d6
https://pubmed.ncbi.nlm.nih.gov/17157013
https://pubmed.ncbi.nlm.nih.gov/17157013