Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Ken Berglund"'
Autor:
Assunta Merolla, Caterina Michetti, Matteo Moschetta, Francesca Vacca, Lorenzo Ciano, Laura Emionite, Simonetta Astigiano, Alessandra Romei, Simone Horenkamp, Ken Berglund, Robert E. Gross, Fabrizia Cesca, Elisabetta Colombo, Fabio Benfenati
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Epilepsy affects 1% of the general population and 30% of patients are resistant to antiepileptic drugs. Although optogenetics is an efficient antiepileptic strategy, the difficulty of illuminating deep brain areas poses translational challen
Externí odkaz:
https://doaj.org/article/56532149b4104924a08c84940730103d
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Despite an abundance of pharmacologic and surgical epilepsy treatments, there remain millions of patients suffering from poorly controlled seizures. One approach to closing this treatment gap may be found through a deeper mechanistic understanding of
Externí odkaz:
https://doaj.org/article/2220ed75e708459fa3d1498204c9d763
Autor:
Michael Q. Jiang, Shan Ping Yu, Takira Estaba, Emily Choi, Ken Berglund, Xiaohuan Gu, Ling Wei
Publikováno v:
Cells, Vol 13, Iss 11, p 897 (2024)
Glioblastoma Multiforme (GBM) is an aggressive brain tumor with a high mortality rate. Direct reprogramming of glial cells to different cell lineages, such as induced neural stem cells (iNSCs) and induced neurons (iNeurons), provides genetic tools to
Externí odkaz:
https://doaj.org/article/d9f96a52e6a14a819bd34e608ad3d040
Autor:
Michael Qize Jiang, Shan Ping Yu, Zheng Zachory Wei, Weiwei Zhong, Wenyuan Cao, Xiaohuan Gu, Anika Wu, Myles Randolph McCrary, Ken Berglund, Ling Wei
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
The master neuronal transcription factor NeuroD1 can directly reprogram astrocytes into induced neurons (iNeurons) after stroke. Using viral vectors to drive ectopic ND1 expression in gliotic astrocytes after brain injury presents an autologous form
Externí odkaz:
https://doaj.org/article/1b570d71918344d4aec6e15f611f09fa
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59759 (2013)
Manipulation of neuronal activity through genetically targeted actuator molecules is a powerful approach for studying information flow in the brain. In these approaches the genetically targeted component, a receptor or a channel, is activated either
Externí odkaz:
https://doaj.org/article/e1ff33fc60544cdebe97e3b9340f6457
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 24; Pages: 16084
Introduction—Recovery from peripheral nerve injuries is poor even though injured peripheral axons can regenerate. Novel therapeutic approaches are needed. The most successful preclinical experimental treatments have relied on increasing the activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0810fa6399f8efd75a87f414f3ae9ec
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c3e793f600889c40f3aeac12dae33c8
https://doi.org/10.1002/alz.067285
https://doi.org/10.1002/alz.067285
Autor:
Xin-Qiu Yao, Ning Fang, Angela M. Mabb, Zheng Zachory Wei, Daniel Ouedraogo, Giovanni Gadda, You Zhuo, Ken Berglund, Bin Dong, Cheyenne McBean, Xiaonan Deng, Shan Ping Yu, Jenny J. Yang, Samer Gozem, Mohammad A Ghane, Ling Wei, Donald Hamelberg
Publikováno v:
Angewandte Chemie. 133:23477-23486
Multi-scale calcium (Ca2+ ) dynamics, exhibiting wide-ranging temporal kinetics, constitutes a ubiquitous mode of signal transduction. We report a novel endoplasmic-reticulum (ER)-targeted Ca2+ indicator, R-CatchER, which showed superior kinetics in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e3a21f6ed6ae61d826c654a16ee3b2
https://doi.org/10.1002/ange.202108443
https://doi.org/10.1002/ange.202108443
Autor:
Fu Hung Shiu, Henry Skelton, Ken Berglund, Alejandra M. Fernandez, Claire-Anne N. Gutekunst, Elizabeth R. Robinson, Zuhui Wang, Robert E. Gross
Previous studies in human patients and rodent models of Parkinson’s disease (PD) have established neuroprotection of dopaminergic (DA) neurons in substantia nigra pars compacta (SNC) by physical exercise, but the precise origin of this neuroprotect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aba4db4ad1b2265202f6bffc4bdddf67
https://doi.org/10.1101/2022.10.17.512538
https://doi.org/10.1101/2022.10.17.512538
Autor:
Matthew A, Stern, Henry, Skelton, Alejandra M, Fernandez, Claire-Anne N, Gutekunst, Ken, Berglund, Robert E, Gross
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2525
Manipulation of neural activity in genetically predefined populations of neurons through genetic techniques is an essential tool in the field of neuroscience as well as a potential avenue in treating a vast assortment of neurological and psychiatric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ef341e11c3ca2c019d4e3da07a40a01
https://pubmed.ncbi.nlm.nih.gov/35836081
https://pubmed.ncbi.nlm.nih.gov/35836081