Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Ken Arae"'
Autor:
Ken Arae, Masashi Ikutani, Kotaro Horiguchi, Sachiko Yamaguchi, Youji Okada, Hiroki Sugiyama, Keisuke Orimo, Hideaki Morita, Hajime Suto, Ko Okumura, Haruhiko Taguchi, Kenji Matsumoto, Hirohisa Saito, Katsuko Sudo, Susumu Nakae
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Exposure to various antigens derived from house dust mites (HDM) is considered to be a risk factor for development of certain allergic diseases such as atopic asthma, atopic dermatitis, rhinitis and conjunctivitis. Chitin is an insoluble pol
Externí odkaz:
https://doaj.org/article/b2ff8b41fa784b708de791905ef9f743
Autor:
Masato Tamari, Keisuke Orimo, Kenichiro Motomura, Ken Arae, Akio Matsuda, Susumu Nakae, Hirohisa Saito, Hideaki Morita, Kenji Matsumoto
Publikováno v:
Allergology International, Vol 67, Iss 3, Pp 380-387 (2018)
Background: Direct contact of food proteins with eczematous lesions is thought to be the main cause of epicutaneous sensitization. To further investigate the development and pathogenesis of food allergy in vivo, a good mouse model of epicutaneous sen
Externí odkaz:
https://doaj.org/article/88653586ed794c05b2229ac8404d4b15
Autor:
Ayako Takamori, Aya Nambu, Keiko Sato, Sachiko Yamaguchi, Kenshiro Matsuda, Takafumi Numata, Takeru Sugawara, Takamichi Yoshizaki, Ken Arae, Hideaki Morita, Kenji Matsumoto, Katsuko Sudo, Ko Okumura, Jiro Kitaura, Hiroshi Matsuda, Susumu Nakae
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract IL-31, which is a member of the IL-6 family of cytokines, is produced mainly by activated CD4+ T cells, in particular activated Th2 cells, suggesting a contribution to development of type-2 immune responses. IL-31 was reported to be increase
Externí odkaz:
https://doaj.org/article/132de0ad94d94b119863cbd4870bdb3d
Publikováno v:
Allergology International, Vol 62, Iss 1, Pp 13-20 (2013)
Interleukin-33 (IL-33), a member of the IL-1 cytokine family, is preferentially and constitutively expressed in epithelial cells, and it is especially localized in the cells' nucleus. The nuclear IL-33 is released by necrotic cells after tissue injur
Externí odkaz:
https://doaj.org/article/0aa57dd82bcc4c83af06c556849e5658
ST2 Requires Th2-, but Not Th17-, Type Airway Inflammation in Epicutaneously Antigen-Sensitized Mice
Autor:
Hideaki Morita, Ken Arae, Tatsukuni Ohno, Naoki Kajiwara, Keisuke Oboki, Akio Matsuda, Hajime Suto, Ko Okumura, Katsuko Sudo, Takao Takahashi, Kenji Matsumoto, Susumu Nakae
Publikováno v:
Allergology International, Vol 61, Iss 2, Pp 265-273 (2012)
Background: IL-33 is known to induce Th2-type cytokine production by various types of cells through its receptors, ST2 and IL-1RAcP. Polymorphism in the ST2 and/or IL-33 genes was found in patients with atopic dermatitis and asthma, implying that the
Externí odkaz:
https://doaj.org/article/37e0ba2f7cd843a18b856e0516ea8eb9
Autor:
Ken Arae, Keisuke Oboki, Tatsukuni Ohno, Masako Hirata, Susumu Nakae, Haruhiko Taguchi, Hirohisa Saito, Toshiharu Nakajima
Publikováno v:
Allergology International, Vol 60, Iss 3, Pp 339-344 (2011)
Background: Treatment with anti-ulcer drugs has been shown to enhance IgE production against food antigens. However, little is known about the immunological effects of cimetidine, a histamine receptor type 2 (H2R) antagonist that is widely used as an
Externí odkaz:
https://doaj.org/article/a892c79ab5c64781b22b7fcd3588ab54
Autor:
Akina Ishii, Keisuke Oboki, Aya Nambu, Hideaki Morita, Tatsukuni Ohno, Naoki Kajiwara, Ken Arae, Hajime Sudo, Ko Okumura, Hirohisa Saito, Susumu Nakae
Publikováno v:
Allergology International, Vol 59, Iss 4, Pp 399-408 (2010)
Background: IL-25, which is a member of the IL-17 family, induces Th2 cell differentiation and Th2 cytokine production, contributing to induction of Th2-type immune responses and diseases, as a result of which it suppresses Th1- and Th17-type immune
Externí odkaz:
https://doaj.org/article/4dfa12d510fb43848f3a5086d6e2beb4
Autor:
Hideaki Morita, Ken Arae, Hirotoshi Unno, Sumika Toyama, Kenichiro Motomura, Akio Matsuda, Hajime Suto, Ko Okumura, Katsuko Sudo, Takao Takahashi, Hirohisa Saito, Kenji Matsumoto, Susumu Nakae
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0134226 (2015)
IL-25, IL-33 and TSLP are produced predominantly by epithelial cells and are known to induce Th2-type cytokines. Th2-type cytokines are involved not only in host defense against nematodes, but also in the development of Th2-type allergic diseases. TS
Externí odkaz:
https://doaj.org/article/2a9b17100f2d485dab465686154d5b83
Autor:
Tatsukuni Ohno, Keisuke Oboki, Hideaki Morita, Naoki Kajiwara, Ken Arae, Shizuko Tanaka, Masako Ikeda, Motoyasu Iikura, Taishin Akiyama, Jun-ichiro Inoue, Kenji Matsumoto, Katsuko Sudo, Miyuki Azuma, Ko Okumura, Thomas Kamradt, Hirohisa Saito, Susumu Nakae
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18404 (2011)
BackgroundIL-33, a member of the IL-1 family of cytokines, provokes Th2-type inflammation accompanied by accumulation of eosinophils through IL-33R, which consists of ST2 and IL-1RAcP. We previously demonstrated that macrophages produce IL-33 in resp
Externí odkaz:
https://doaj.org/article/84558daedbd3469eb3317bb929bb70a9
Autor:
Kyoko Saito, Keisuke Orimo, Terufumi Kubo, Masato Tamari, Ayako Yamada, Kenichiro Motomura, Hiroki Sugiyama, Ryo Matsuoka, Naoko Nagano, Yuka Hayashi, Ken Arae, Mariko Hara, Masashi Ikutani, Tatsuki Fukuie, Katsuko Sudo, Akio Matsuda, Yukihiro Ohya, Shigeharu Fujieda, Hirohisa Saito, Susumu Nakae, Kenji Matsumoto, Cezmi A. Akdis, Hideaki Morita
Publikováno v:
Allergy.