Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Ken Akamatsu"'
Autor:
Naoya Shikazono, Ken Akamatsu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Clustered DNA damage, when multiple lesions are generated in close proximity, has various biological consequences, including cell death, chromosome aberrations, and mutations. It is generally perceived as a hallmark of ionizing radiation. Th
Externí odkaz:
https://doaj.org/article/87c8f38024e84c4f98e1ec0815fe396b
Publikováno v:
Chemical Communications. 59:6088-6091
Dimethyllumazine (DML)-thiazole orange (TO) conjugates were developed for fluorescence sensing of thymine glycol (Tg)-containing DNAs based on the selective recognition of the A nucleobase opposite the Tg residue.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c245a497a6780d1ff45f03f0e54443b
https://doi.org/10.1039/d3cc01501g
https://doi.org/10.1039/d3cc01501g
集光されたフェムト秒レーザーにより形成した水中フィラメント内では、高反応性の水和電子やヒドロキシラジカルが生成し、近傍に有機物が存在するとラジカル反応が起こると考えら
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::131081196d11b6eb5b98e8e6d0baf5bc
https://repo.qst.go.jp/records/86245
https://repo.qst.go.jp/records/86245
放射線が誘発するDNAの局所的な多重損傷部位(クラスター損傷)は、放射線の生物学的影響と密接に関係していると考えられている。しかしながらこれまでクラスター損傷を解析する方法
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::71806d4b62ed4e3a86490b96a46909ce
https://repo.qst.go.jp/records/86105
https://repo.qst.go.jp/records/86105
Publikováno v:
Analytical and Bioanalytical Chemistry. 413:1185-1192
A clustered DNA damage site (cluster), in which two or more lesions exist within a few helical turns, is believed to be a key factor determining the fate of a living cell exposed to a DNA damaging agent such as ionizing radiation. However, the struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4296c080d68dac6873d1204ed03d0e
https://doi.org/10.1007/s00216-020-03082-w
https://doi.org/10.1007/s00216-020-03082-w
Publikováno v:
Analytical and Bioanalytical Chemistry. 413:1185-1192
DNA lesion induced by ionizing radiation and chemicals can cause mutation and carcinogenesis. In particular, clustered DNA damage site (cluster), that is a DNA region with multiple lesions within a few helical turns, is believed to hardly be repaired
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::0a74e7bf7f71416aa284f9b4c9db13b8
https://repo.qst.go.jp/records/81150
https://repo.qst.go.jp/records/81150
Autor:
Ken Akamatsu, Naoya Shikazono
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
The damaging potential of ionizing radiation arises largely from the generation of clustered DNA damage sites within cells. Previous studies using synthetic DNA lesions have demonstrated that models of clustered DNA damage exhibit enhanced mutagenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545faabc262210cd4cb4d793d14001b4
http://link.springer.com/article/10.1038/s41598-020-66651-0
http://link.springer.com/article/10.1038/s41598-020-66651-0
Autor:
Toshiaki Nakano, Ken Akamatsu, Masataka Tsuda, Ayane Tujimoto, Ryoichi Hirayama, Takeshi Hiromoto, Taro Tamada, Hiroshi Ide, Naoya Shikazono
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Significance DNA damage causes loss of or alterations in genetic information, resulting in cell death or mutations. Ionizing radiations produce local, multiple DNA damage sites called clustered DNA damage. In this study, a complete protocol was estab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c1809178e21a2c7fa6cf42aaf73bdb
https://doi.org/10.1073/pnas.2119132119
https://doi.org/10.1073/pnas.2119132119
Autor:
Toshiaki, Nakano, Ken, Akamatsu
DNA-タンパク質クロスリンク損傷 (DPCs) は、環境変異原等の外的或いは代謝過程など内的要因で生じるDNA損傷である。その初期修復過程においてメタロプロテアーゼの一種のSPRTNがクロス
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::6a1e19ee80ab075d35fbc25c24ccc2c9
https://repo.qst.go.jp/records/83640
https://repo.qst.go.jp/records/83640
Autor:
Toshiaki, Nakano, Ken, Akamatsu, Ryoichi, Hirayama, Takeshi, Hiromoto, Taro, Tamada, Naoya, Shikazono
Radiation-induced local multiple damage to DNA (cluster DNA damage) is thought to be closely related to the biological effects of radiation. We developed a new protocol to visualize DNA damage in genomic DNA extracted from TK6 cells irradiated with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::a700f56bb0c92db72f021a655bd52358
https://repo.qst.go.jp/records/83432
https://repo.qst.go.jp/records/83432