Obesity dysregulates the pulmonary antiviral immune response

Autor: Mark Almond, Hugo A. Farne, Millie M. Jackson, Akhilesh Jha, Orestis Katsoulis, Oliver Pitts, Tanushree Tunstall, Eteri Regis, Jake Dunning, Adam J. Byrne, Patrick Mallia, Onn Min Kon, Ken A. Saunders, Karen D. Simpson, Robert J. Snelgrove, Peter J. M. Openshaw, Michael R. Edwards, Wendy S. Barclay, Liam M. Heaney, Sebastian L. Johnston, Aran Singanayagam

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract Obesity is a well-recognized risk factor for severe influenza infections but the mechanisms underlying susceptibility are poorly understood. Here, we identify that obese individuals have deficient pulmonary antiviral immune responses in bron

Externí odkaz: https://doaj.org/article/8d985523dc6242578a25e3fd4216932b

Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients

Autor: Benoit Pugin, Weronika Barcik, Peter Schmid-Grendelmeier, David L. Mayhew, Liam O'Mahony, Marek Jutel, Noelia Rodriguez-Perez, Stephanie Van Horn, Pawel Gajdanowicz, Remo Frei, Katrine Graversen, Noriane A. Sievi, Milena Sokolowska, Sylwia Smolinska, Edith M. Hessel, Ken A. Saunders, Can Altunbulakli, Magdalena Kurnik-Lucka, Michal Pirozynski, David Michalovich, Sorif Uddin, Cezmi A. Akdis, Andrzej Eljaszewicz, Katrine Lindholm Bøgh, Karen D. Simpson, James R. Brown, Malcolm Kohler, Ruth Ferstl

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Michalovich, D, Rodriguez-Perez, N, Smolinska, S, Pirozynski, M, Mayhew, D, Uddin, S, Van Horn, S, Sokolowska, M, Altunbulakli, C, Eljaszewicz, A, Pugin, B, Barcik, W, Kurnik-Lucka, M, Saunders, K A, Simpson, K D, Schmid-Grendelmeier, P, Ferstl, R, Frei, R, Sievi, N, Kohler, M, Gajdanowicz, P, Graversen, K B, Bøgh, K L, Jutel, M, Brown, J R, Akdis, C A, Hessel, E M & O'Mahony, L 2019, ' Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients ', Nature Communications, vol. 10, 5711 . https://doi.org/10.1038/s41467-019-13751-9

In order to improve targeted therapeutic approaches for asthma patients, insights into the molecular mechanisms that differentially contribute to disease phenotypes, such as obese asthmatics or severe asthmatics, are required. Here we report immunolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7386b58dedeff4e6e0f23dc49d521f
https://doaj.org/article/cd01b505faaf4615b453f12d29b2725d

Exploring PI3Kδ Molecular Pathways in Stable COPD and Following an Acute Exacerbation, Two Randomized Controlled Trials

Autor: Ken A. Saunders, Robert Wilson, Wim Vos, Cedric Van Holsbeke, Jan De Backer, Claude Poirier, Glyn Bradley, Ingrid Louise Titlestad, Emily Jarvis, Kieran J. Killian, J. Nicole Hamblin, Stephen Mark, Mark Lennon, Anthony Cahn, Augustin Amour, Rikako Tanaka, Teresa Tang, Edith M. Hessel, David Michalovich, Hannah E Wajdner, J. Mark FitzGerald, Malcolm Begg, Jean Bourbeau, Saki Arai, François Maltais

Publikováno v: International Journal of COPD, Vol Volume 16, Pp 1621-1636 (2021)
Begg, M, Hamblin, J N, Jarvis, E, Bradley, G, Mark, S, Michalovich, D, Lennon, M, Wajdner, H E, Amour, A, Wilson, R, Saunders, K, Tanaka, R, Arai, S, Tang, T, Van Holsbeke, C, De Backer, J, Vos, W, Titlestad, I L, FitzGerald, J M, Killian, K, Bourbeau, J, Poirier, C, Maltais, F, Cahn, A & Hessel, E M 2021, ' Exploring PI3Kδ molecular pathways in stable COPD and following an acute exacerbation, two randomized controlled trials ', International Journal of COPD, vol. 16, pp. 1621-1636 . https://doi.org/10.2147/COPD.S309303
International Journal of Chronic Obstructive Pulmonary Disease

Malcolm Begg,1 J Nicole Hamblin,1 Emily Jarvis,2 Glyn Bradley,3 Stephen Mark,4 David Michalovich,5 Mark Lennon,6 Hannah E Wajdner,5 Augustin Amour,5 Robert Wilson,1 Ken Saunders,5 Rikako Tanaka,7 Saki Arai,7 Teresa Tang,8 Cedric Van Holsbeke,9 Jan De

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534353e7f13ce5b059238bb5b578407c
https://www.dovepress.com/exploring-pi3k-molecular-pathways-in-stable-copd-and-following-an-acut-peer-reviewed-fulltext-article-COPD

Design of Phthalazinone Amide Histamine H1 Receptor Antagonists for Use in Rhinitis

Autor: Robert J. Slack, Brian Edgar Looker, Sadie Vile, Duncan S. Holmes, Kenneth L. Clark, Clarissa J. Watts, Simon Teanby Hodgson, Panayiotis A. Procopiou, Paul Martin Gore, Ken A. Saunders, Alison J. Ford, James E. Rowedder

Publikováno v: ACS Medicinal Chemistry Letters. 8:577-581

The synthesis of potent amide-containing phthalazinone H1 histamine receptor antagonists is described. Three analogues 3e, 3g, and 9g were equipotent with azelastine and were longer-acting in vitro. Amide 3g had low oral bioavailability, low brain-pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d844710395fd4e67453aec5659bdbd6b
https://doi.org/10.1021/acsmedchemlett.7b00112

Design of Phthalazinone Amide Histamine H

Autor: Panayiotis A, Procopiou, Alison J, Ford, Paul M, Gore, Brian E, Looker, Simon T, Hodgson, Duncan S, Holmes, Sadie, Vile, Kenneth L, Clark, Ken A, Saunders, Robert J, Slack, James E, Rowedder, Clarissa J, Watts

Publikováno v: ACS medicinal chemistry letters. 8(5)

The synthesis of potent amide-containing phthalazinone H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d4250f252957aff9c3f10f377df74236
https://pubmed.ncbi.nlm.nih.gov/28523114