Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ken A. Newlander"'
Autor:
Octerloney B. McDonald, Carla A. Donatelli, William F. Huffman, Toshihiro Hamajima, Christine Thompson, Kelly E. Fisher, Martha A. Sarpong, Jamin C Wang, David Sutton, Dashyant Dhanak, Peter J. Tummino, Jun Tang, Ken A. Newlander, Zhihong V Lai, Hong Xiang, Kosuke Sasaki, Domingos J. Silva, Mary Ann Hardwicke, Jerry L. Adams, Cynthia A. Parrish, Schmidt Stanley J, Denis R. Patrick, Hiroko Nakamura, Jingsong Yang, Catherine A. Oleykowski, Robert A. Copeland, Amita M. Chaudhari, Ramona Plant, David H. Drewry, Kristin K Koretke-Brown, Nicholas D. Adams, Joelle Lorraine Burgess
Publikováno v:
Journal of Medicinal Chemistry. 53:3973-4001
The Aurora kinases play critical roles in the regulation of mitosis and are frequently overexpressed or amplified in human tumors. Selective inhibitors may provide a new therapy for the treatment of tumors with Aurora kinase amplification. Herein we
Autor:
Ken A. Newlander, Denis R. Patrick, Dashyant Dhanak, Jingsong Yang, Mary Ann Hardwicke, Catherine A. Oleykowski, Jerry L. Adams, Zhihong Lai, David Sutton, Jamin Wang, Ramona Plant, Qiaoyin Liao, Katherine G. Moss
Publikováno v:
Molecular Cancer Therapeutics. 8:1808-1817
The protein kinases, Aurora A, B, and C have critical roles in the regulation of mitosis and are frequently overexpressed or amplified in human tumors. GSK1070916, is a novel ATP competitive inhibitor that is highly potent and selective for Aurora B/
Autor:
William F. Huffman, Ken A. Newlander, Amita M. Chaudhari, Shu-Yun Zhang, Michael L. Moore, Jeffrey T. Finer, Kevin J. Duffy, Antony N. Shaw, Melody Diamond, David Sutton, Robert A. Copeland, Michael N. Zimmerman, Chiu-Mei M Sung, Leo F. Faucette, Roman Sakowicz, Jeffrey R. Jackson, Lusong Luo, Kurt R. Auger, Kenneth W. Wood, Jeffrey D. Carson, Carla A. Donatelli, Cynthia A. Parrish, Erin D. Hugger, Steven D. Knight, Lance Ridgers, Nicholas D. Adams, Joelle Lorraine Burgess, Dashyant Dhanak
Publikováno v:
Journal of Medicinal Chemistry. 50:4939-4952
Kinesin spindle protein (KSP), an ATPase responsible for spindle pole separation during mitosis that is present only in proliferating cells, has become a novel and attractive anticancer target with potential for reduced side effects compared to curre
Autor:
Duke M. Fitch, Stephen Schauer, Steven D. Knight, Zhengping Wang, Michael N. Zimmerman, Kurt R. Auger, Roman Sakowicz, Dashyant Dhanak, Han-Jie Zhou, Amita M. Chaudhari, Carrie E. Aroyan, Jeffrey T. Finer, Deping Chai, Jeffrey R. Jackson, Lance Ridgers, Luke W. Ashcraft, Seyed Ahmed, Kenneth Wood, Erin D. Hugger, Jennifer Kuo Chen Huang, Melchor V. Marin, John D. Elliott, Andrew Mcdonald, Cynthia A. Parrish, David Sutton, Ramesh Baliga, Mariela Colón, Lisa D. Belmont, Carla A. Donatelli, Nicholas D. Adams, Joelle Lorraine Burgess, Hong Jiang, Rosanna Tedesco, Bing Yao, Jianchao Wang, Kevin J. Duffy, Gustave Bergnes, Xiangping Qian, Chiu-Mei Sung, David J. Morgans, Robert A. Copeland, Bradley P. Morgan, Michael G. Darcy, Jeffrey D. Carson, Latesh Lad, Ken A. Newlander, Lusong Luo, Daniel W. Pierce, Schmidt Stanley J
Publikováno v:
ACS medicinal chemistry letters. 1(1)
Inhibition of mitotic kinesins represents a novel approach for the discovery of a new generation of anti-mitotic cancer chemotherapeutics. We report here the discovery of the first potent and selective inhibitor of centromere-associated protein E (CE
Autor:
Michael T. McCabe, Christine Thompson, Ryan G. Kruger, Caretha L. Creasy, Louis V. LaFrance, Stuart Paul Romeril, Mellinger Mark, Charles F. McHugh, Xinrong Tian, Peter J. Tummino, Dash Dhanak, Ken A. Newlander, Dominic Suarez, Alan P. Graves, Celine Duquenne, Brackley James, Sharad K. Verma, BaoChau Le, Daryl A. Scherzer, Steven D. Knight, Johnson Neil W, William H. Miller, Elsie Diaz, Seth W. Grant, Art Shu, Heidi Morgan-Ott, Joelle Lorraine Burgess
Publikováno v:
Cancer Research. 72:2939-2939
The histone methyltransferases are a group of enzymes which catalyze the transfer of a methyl group from the co-factor S-Adenosylmethionine (SAM) to the lysine and arginine residues of histone tails. This post-translational modification is a key even
Autor:
Christine M. Gardiner, Martha A. Sarpong, Kaushik Raha, Ken A. Newlander, Kurt R. Auger, Steven D. Knight, Cynthia A. Parrish, Lance Ridgers, Glenn S. Van Aller, Carla A. Donatelli, Amita M. Chaudhari, Peter J. Tummino, Schmidt Stanley J, Chiu-Mei Sung, Eric Garver, Jeffrey D. Carson, Michael G. Darcy, Lusong Luo, Dashyant Dhanak, Nicholas D. Adams, Joelle Lorraine Burgess, Patricia A. Elkins, Melody Diamond
Publikováno v:
Molecular Cancer Therapeutics. 8:C62-C62
Phosphoinositide 3-kinase (PI3K) is a critical regulator of cell growth and transformation and its signaling pathway is one of the most commonly mutated pathways in human cancer. The mammalian target of rapamycin (mTOR), a class IV PI3K protein kinas
Autor:
Cynthia A. Parrish, Nicholas D. Adams, Kurt R. Auger, Joelle L. Burgess, Jeffrey D. Carson, Amita M. Chaudhari, Robert A. Copeland, Melody A. Diamond, Carla A. Donatelli, Kevin J. Duffy, Leo F. Faucette, Jeffrey T. Finer, William F. Huffman, Erin D. Hugger, Jeffrey R. Jackson, Steven D. Knight, Lusong Luo, Michael L. Moore, Ken A. Newlander, Lance H. Ridgers
Publikováno v:
Journal of Medicinal Chemistry; Oct2007, Vol. 50 Issue 20, p4939-4952, 14p