Zobrazeno 1 - 10
of 654
pro vyhledávání: '"Ken Hashimoto"'
Autor:
Ken Hashimoto, Momoko Ohira, Aya Kodama, Misaki Kimoto, Mariko Inoue, Shigenobu Toné, Yuu Usui, Akira Hanashima, Takato Goto, Yuhei Ogura, Yoshihiro Ujihara, Satoshi Mohri
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Connectin (also known as titin) is a giant striated muscle protein that functions as a molecular spring by providing elasticity to the sarcomere. Novex-3 is a short splice variant of connectin whose physiological function remains unknown. We
Externí odkaz:
https://doaj.org/article/fe32e50ac23e47c2b48acd3c8f4b729c
Autor:
Hiroshi Kondo, Keiko Mukaida, Kurumi Sasai, Yukiko Nao, Ken Hashimoto, Hirotsugu Miyoshi, Rieko Kanzaki, Yasuo M. Tsutsumi
Publikováno v:
JA Clinical Reports, Vol 10, Iss 1, Pp 1-4 (2024)
Abstract Background Malignant hyperthermia (MH) is a rare, life-threatening disorder of calcium homeostasis in skeletal muscle cells that is triggered by volatile anesthetics and succinylcholine, leading to a hypermetabolic reaction. The pathogenic r
Externí odkaz:
https://doaj.org/article/a5f06aa404f643a7bad19c1f239fee4c
Publikováno v:
Physiological Reports, Vol 12, Iss 8, Pp n/a-n/a (2024)
Abstract Investigating ventricular diastolic properties is crucial for understanding the physiological cardiac functions in organisms and unraveling the pathological mechanisms of cardiovascular disorders. Ventricular stiffness, a fundamental paramet
Externí odkaz:
https://doaj.org/article/713f85017153452d816fb63131313657
Autor:
Ken Hashimoto, Aya Kodama, Momoko Ohira, Misaki Kimoto, Reiko Nakagawa, Yuu Usui, Yoshihiro Ujihara, Akira Hanashima, Satoshi Mohri
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104337- (2022)
Summary: Introduction of fetal cell cycle genes into damaged adult hearts has emerged as a promising strategy for stimulating proliferation and regeneration of postmitotic adult cardiomyocytes. We have recently identified Fam64a as a fetal-specific c
Externí odkaz:
https://doaj.org/article/429d7ae3ebc64ddf9841f25e3c8012e6
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0267264 (2022)
Ventricular diastolic mechanical properties are important determinants of cardiac function and are optimized by changes in cardiac structure and physical properties. Oncorhynchus masou masou is an anadromous migratory fish of the Salmonidae family, a
Externí odkaz:
https://doaj.org/article/dcdc0973d4374db6b8677f1f38c1c6a5
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
In CBA/CaJ mice, confocal analysis has shown that acoustic overexposure can immediately destroy synapses between auditory-nerve fibers (ANFs) and their peripheral targets, the inner hair cells (IHCs), and that years later, a corresponding number of A
Externí odkaz:
https://doaj.org/article/433b9e476ad34f92b94f01b90b645538
Autor:
Ken Hashimoto, Tyler T. Hickman, Jun Suzuki, Lingchao Ji, David C. Kohrman, Gabriel Corfas, M. Charles Liberman
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Noise exposures causing only transient threshold shifts can destroy auditory-nerve synapses without damaging hair cells. Here, we asked whether virally mediated neurotrophin3 (NT3) overexpression can repair this damage. CBA/CaJ mice at 6 wks
Externí odkaz:
https://doaj.org/article/ee0860e21d1648468a10153d8c2a20c3
Autor:
Jun Suzuki, Ryoukichi Ikeda, Kengo Kato, Risako Kakuta, Yuta Kobayashi, Akira Ohkoshi, Ryo Ishii, Ai Hirano-Kawamoto, Jun Ohta, Rei Kawata, Tomonori Kanbayashi, Masaki Hatano, Tadahisa Shishido, Yuya Miyakura, Kento Ishigaki, Yasunari Yamauchi, Miho Nakazumi, Takuya Endo, Hiroki Tozuka, Shiori Kitaya, Yuki Numano, Shotaro Koizumi, Yutaro Saito, Mutsuki Unuma, Ken Hashimoto, Eiichi Ishida, Toshiaki Kikuchi, Takayuki Kudo, Kenichi Watanabe, Masaki Ogura, Masaru Tateda, Takatsuna Sasaki, Nobuo Ohta, Tatsuma Okazaki, Yukio Katori
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254261 (2021)
BackgroundPneumonia is a common cause of illness and death of the elderly in Japan. Its prevalence is escalating globally with the aging of population. To describe the latest trends in pneumonia hospitalizations, especially aspiration pneumonia (AP)
Externí odkaz:
https://doaj.org/article/3f036c3742b34b7689ba042bab7d3a0f
Publikováno v:
Health Systems & Reform, Vol 6, Iss 1 (2020)
Haiti announced in 2018 its aim to achieve universal health coverage. In this paper, we discuss what this objective means for the country and what next steps should be taken. To contextualize the notion, we framed Haiti en route to the 2030 goal and
Externí odkaz:
https://doaj.org/article/79895f6a151942ac9f54146e1feb7a64
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008851 (2020)
Externí odkaz:
https://doaj.org/article/3b907be88ee342fda4d4507a6a671ca2