Zobrazeno 1 - 10
of 446
pro vyhledávání: '"Ken, Mackie"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The Cannabis sativa plant has been used for centuries as a recreational drug and more recently in the treatment of patients with neurological or psychiatric disorders. In many instances, treatment goals include relief from posttraumatic diso
Externí odkaz:
https://doaj.org/article/87e03128e9d94a0980d17f2202990c0c
Publikováno v:
Cyborg and Bionic Systems, Vol 5 (2024)
Personalized pain medicine aims to tailor pain treatment strategies for the specific needs and characteristics of an individual patient, holding the potential for improving treatment outcomes, reducing side effects, and enhancing patient satisfaction
Externí odkaz:
https://doaj.org/article/60a6f3ff71eb45a2909f6fc2931adcea
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Autaptic hippocampal neurons are an architecturally simple model of neurotransmission that express several forms of cannabinoid signaling. Over the past twenty years this model has proven valuable for studies ranging from enzymatic control o
Externí odkaz:
https://doaj.org/article/2380e0c857834d04a1b5d92f15368679
Autor:
Hongwei Cai, Zheng Ao, Chunhui Tian, Zhuhao Wu, Connor Kaurich, Zi Chen, Mingxia Gu, Andrea G. Hohmann, Ken Mackie, Feng Guo
Publikováno v:
Bioactive Materials, Vol 22, Iss , Pp 482-490 (2023)
pioids are commonly used for treating chronic pain. However, with continued use, they may induce tolerance and/or hyperalgesia, which limits therapeutic efficacy. The human mechanisms of opioid-induced tolerance and hyperalgesia are significantly und
Externí odkaz:
https://doaj.org/article/333e4ae18a1e433886dd356eb43bf637
Autor:
Audrey Flavin, Paniz Azizi, Natalia Murataeva, Kyle Yust, Wenwen Du, Ruth Ross, Iain Greig, Thuy Nguyen, Yanan Zhang, Ken Mackie, Alex Straiker
Publikováno v:
Molecules, Vol 29, Iss 8, p 1881 (2024)
While the opioid crisis has justifiably occupied news headlines, emergency rooms are seeing many thousands of visits for another cause: cannabinoid toxicity. This is partly due to the spread of cheap and extremely potent synthetic cannabinoids that c
Externí odkaz:
https://doaj.org/article/54a9a8ab5fc1420d99b822d2986bffd9
Autor:
Junhua Xu, Hongwei Cai, Zhuhao Wu, Xiang Li, Chunhui Tian, Zheng Ao, Vivian C. Niu, Xiao Xiao, Lei Jiang, Marat Khodoun, Marc Rothenberg, Ken Mackie, Jun Chen, Luke P. Lee, Feng Guo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Treating acute disease like anaphylaxis is challenging due to the inability to administer therapeutics in a timely manner and regulate pharmacokinetics precisely within a short time window. Here the authors develop active acoustic metamaterials-drive
Externí odkaz:
https://doaj.org/article/3897913d9a1f4303a8911ee43f96767c
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
In the central nervous system (CNS), cannabinoid receptor 1 (CB1R) is preferentially expressed in axons where it has a unique property, namely resistance to agonist-driven endocytosis. This review aims to summarize what we know about molecular mechan
Externí odkaz:
https://doaj.org/article/df5d42bd43654248a5835939fb35c23b
Autor:
Rachel M. Kalbfell, Devin J. Rettke, Ken Mackie, Keisuke Ejima, Jaroslaw Harezlak, Isabella L. Alexander, Jim Wager-Miller, Blair D. Johnson, Sharlene D. Newman, Keisuke Kawata
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106948- (2023)
Summary: Cannabis use has become popular among athletes, many of whom are exposed to repetitive subconcussive head impacts. We aimed to test whether chronic cannabis use would be neuroprotective or exacerbating against acute subconcussive head impact
Externí odkaz:
https://doaj.org/article/54fa16ab95e040b191e24aa8d98790f8
Publikováno v:
IBRO Neuroscience Reports, Vol 11, Iss , Pp 144-155 (2021)
Long-term cannabis use during adolescence has deleterious effects in brain that are largely ascribed to the activation of cannabinoid-1 receptors (CB1Rs) by delta-9-tetrahydrocannabinol (∆9-THC), the primary psychoactive compound in marijuana. Syst
Externí odkaz:
https://doaj.org/article/4dda8a90b7a84e25a34a0dd3069081d0
Autor:
Zsófia I. László, Zsolt Lele, Miklós Zöldi, Vivien Miczán, Fruzsina Mógor, Gabriel M. Simon, Ken Mackie, Imre Kacskovics, Benjamin F. Cravatt, István Katona
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
During embryonic development, neural progenitor cells undergo numerous cell divisions. Here, the authors show that ABHD4-mediated developmental anoikis distinguishes the physiological delamination and the pathological detachment of progenitor cells w
Externí odkaz:
https://doaj.org/article/62189b9ad70741068eea632e23f22e26