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Akademický článek

Ablation of DGKα facilitates α‐smooth muscle actin expression via the Smad and PKCδ signaling pathways during the acute phase of CCl4‐induced hepatic injury

Autor: Keiko Seino, Tomoyuki Nakano, Toshiaki Tanaka, Yasukazu Hozumi, Matthew K. Topham, Kaoru Goto, Ken Iseki

Publikováno v: FEBS Open Bio, Vol 14, Iss 2, Pp 300-308 (2024)

Expression of α‐smooth muscle actin (αSMA) is constitutive in vascular smooth muscle cells, but is induced in nonmuscle cells such as hepatic stellate cells (HSCs). HSCs play important roles in both physiological homeostasis and pathological resp

Externí odkaz: https://doaj.org/article/3068bee3ba404d47bbc2cb2ea859d866

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Akademický článek

Development and external validation of the DOAT and DOATS scores: simple decision support tools to identify disease progression among nonelderly patients with mild/moderate COVID-19

Autor: Yoko Shibata, Kenji Omae, Hiroyuki Minemura, Yasuhito Suzuki, Takefumi Nikaido, Yoshinori Tanino, Atsuro Fukuhara, Ryuzo Kanno, Hiroyuki Saito, Shuzo Suzuki, Taeko Ishii, Yayoi Inokoshi, Eiichiro Sando, Hirofumi Sakuma, Tatsuho Kobayashi, Hiroaki Kume, Masahiro Kamimoto, Hideko Aoki, Akira Takama, Takamichi Kamiyama, Masaru Nakayama, Kiyoshi Saito, Koichi Tanigawa, Masahiko Sato, Toshiyuki Kambe, Norio Kanzaki, Teruhisa Azuma, Keiji Sakamoto, Yuichi Nakamura, Hiroshi Ohtani, Mitsuru Waragai, Shinsaku Maeda, Tokiya Ishida, Keishi Sugino, Minoru Inage, Noriyuki Hirama, Kodai Furuyama, Shigeyuki Fukushima, Hiroshi Saito, Jun-ichi Machiya, Hiroyoshi Machida, Koya Abe, Katsuyoshi Iwabuchi, Yuji Katagiri, Yasuko Aida, Yuki Abe, Takahito Ota, Yuki Ishizawa, Yasuhiko Tsukada, Ryuki Yamada, Riko Sato, Takumi Onuma, Hikaru Tomita, Mikako Saito, Natsumi Watanabe, Mami Rikimaru, Takaya Kawamata, Takashi Umeda, Julia Morimoto, Ryuichi Togawa, Yuki Sato, Junpei Saito, Kenya Kanazawa, Noriaki Kurita, Ken Iseki

Publikováno v: BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-14 (2023)

Abstract Background During the fifth wave of the coronavirus disease 2019 (COVID-19) pandemic in Japan, which took place between June and September 2021, a significant number of COVID-19 cases with deterioration occurred in unvaccinated individuals

Externí odkaz: https://doaj.org/article/ed1ff4d1c8274dfaab28462e42eb1044

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Akademický článek

Oral administration of linoleic acid immediately before glucose load ameliorates postprandial hyperglycemia

Autor: Yuta Yamamoto, Katsuya Narumi, Naoko Yamagishi, Toshio Nishi, Takao Ito, Ken Iseki, Masaki Kobayashi, Yoshimitsu Kanai

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Introduction: Fatty acids are a major nutrient in dietary fat, some of which are ligands of long-chain fatty acid receptors, including G-protein-coupled receptor (GPR) 40 and GPR120. Pretreatment with GPR40 agonists enhanced the secretion of insulin

Externí odkaz: https://doaj.org/article/5044baa0305442aebaf1b6cfa61e6415

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Akademický článek

Traumatic pneumorrhachis associated with cerebral fluid leakage evaluated with magnetic resonance myelography

Autor: Kazuki Sugaya, Ken Iseki

Publikováno v: Clinical Case Reports, Vol 11, Iss 6, Pp n/a-n/a (2023)

Abstract Attention should be paid to cerebrospinal fluid leakage in patients with pneumorrhachis associated with vertebral body trauma. If pneumorrhachis is detected, further imaging investigation and bed rest should be considered as appropriate.

Externí odkaz: https://doaj.org/article/53c194ec25624547ae38cc2ca13819f9

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Akademický článek

Biodistribution and radiation dosimetry of the novel hypoxia PET probe [18F]DiFA and comparison with [18F]FMISO

Autor: Shiro Watanabe, Tohru Shiga, Kenji Hirata, Keiichi Magota, Shozo Okamoto, Takuya Toyonaga, Kei Higashikawa, Hironobu Yasui, Jun Kobayashi, Ken-ichi Nishijima, Ken Iseki, Hiroki Matsumoto, Yuji Kuge, Nagara Tamaki

Publikováno v: EJNMMI Research, Vol 9, Iss 1, Pp 1-11 (2019)

Abstract Background To facilitate hypoxia imaging in a clinical setting, we developed 1-(2,2-dihydroxymethyl-3-[18F]-fluoropropyl)-2-nitroimidazole ([18F]DiFA) as a new tracer that targets tumor hypoxia with its lower lipophilicity and efficient radi

Externí odkaz: https://doaj.org/article/681f36a3288643ba9df1fbbb1bbee786

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Akademický článek

Validation of the usefulness of artificial neural networks for risk prediction of adverse drug reactions used for individual patients in clinical practice.

Autor: Shungo Imai, Yoh Takekuma, Hitoshi Kashiwagi, Takayuki Miyai, Masaki Kobayashi, Ken Iseki, Mitsuru Sugawara

Publikováno v: PLoS ONE, Vol 15, Iss 7, p e0236789 (2020)

Artificial neural networks are the main tools for data mining and were inspired by the human brain and nervous system. Studies have demonstrated their usefulness in medicine. However, no studies have used artificial neural networks for the prediction

Externí odkaz: https://doaj.org/article/fbcb2e77da3d4989a1aa876a829bfbd2

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Akademický článek

Mutual role of ecto-5'-nucleotidase/CD73 and concentrative nucleoside transporter 3 in the intestinal uptake of dAMP.

Autor: Katsuya Narumi, Tsukika Ohata, Yuichi Horiuchi, Hiroshi Satoh, Ayako Furugen, Masaki Kobayashi, Ken Iseki

Publikováno v: PLoS ONE, Vol 14, Iss 10, p e0223892 (2019)

2'-Deoxyadenosine 5'-monophosphate (dAMP), a deoxyribonucleotide found in DNA, affects intestinal cell growth. The molecular mechanisms underlying gastrointestinal absorption of foreign DNA ingested along with food has hardly been investigated. The a

Externí odkaz: https://doaj.org/article/2cc8e8b987074bc9951c93f46d122fde

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