Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ken, Hiratsuka"'
Autor:
Thiago J. Borges, Yoshikazu Ganchiku, Jeffrey O. Aceves, Ronald van Gaal, Sebastien G.M. Uzel, Ivy A. Rosales, Jonathan E. Rubins, Kenichi Kobayashi, Ken Hiratsuka, Murat Tekguc, Guilherme T. Ribas, Karina Lima, Rodrigo B. Gassen, Ryuji Morizane, Jennifer A. Lewis, Leonardo V. Riella
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110957- (2024)
Summary: The increasing scarcity of organs and the significant morbidity linked to dialysis require the development of engineered kidney tissues from human-induced pluripotent stem cells. Integrative approaches that synergize scalable kidney organoid
Externí odkaz:
https://doaj.org/article/a643a4f97bf94f35ad5928910be26236
Autor:
Koichiro Susa, Kenichi Kobayashi, Pierre Galichon, Takuya Matsumoto, Akitoshi Tamura, Ken Hiratsuka, Navin R. Gupta, Iman K. Yazdi, Joseph V. Bonventre, Ryuji Morizane
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Drug nephrotoxicity is a common healthcare problem in hospitalized patients and a major limitation during drug development. Multi-segmented kidney organoids derived from human pluripotent stem cells may complement traditional cell culture and animal
Externí odkaz:
https://doaj.org/article/e2d18dd09a0142409faa4447a4bcf18a
Autor:
Astia Rizki-Safitri, Navin Gupta, Ken Hiratsuka, Kenichi Kobayashi, Chengcheng Zhang, Kazumi Ida, Lisa M. Satlin, Ryuji Morizane
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Kidney organoids derived from hPSCs have opened new opportunities to develop kidney models for preclinical studies and immunocompatible kidney tissues for regeneration. Organoids resemble native nephrons that consist of filtration units and tubules,
Externí odkaz:
https://doaj.org/article/2494cc8c965c4cffb443663848d64f46
Autor:
Rolando Carrisoza-Gaytan, Katharina T. Kroll, Ken Hiratsuka, Navin R. Gupta, Ryuji Morizane, Jennifer A. Lewis, Lisa M. Satlin
Publikováno v:
American Journal of Physiology-Cell Physiology. 324:C757-C768
Kidney organoids cultured on adherent matrices in the presence of superfusate flow generate vascular networks and exhibit more mature podocyte and tubular compartments compared with static controls (Homan KA, Gupta N, Kroll KT, Kolesky DB, Skylar-Sco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e14b8d4224c85726a3b857f3a0998086
https://doi.org/10.1152/ajpcell.00288.2022
https://doi.org/10.1152/ajpcell.00288.2022
Autor:
Yuhki Nakatake, Shigeru B.H. Ko, Alexei A. Sharov, Shunichi Wakabayashi, Miyako Murakami, Miki Sakota, Nana Chikazawa, Chiaki Ookura, Saeko Sato, Noriko Ito, Madoka Ishikawa-Hirayama, Siu Shan Mak, Lars Martin Jakt, Tomoo Ueno, Ken Hiratsuka, Misako Matsushita, Sravan Kumar Goparaju, Tomohiko Akiyama, Kei-ichiro Ishiguro, Mayumi Oda, Norio Gouda, Akihiro Umezawa, Hidenori Akutsu, Kunihiro Nishimura, Ryo Matoba, Osamu Ohara, Minoru S.H. Ko
Publikováno v:
Cell Reports, Vol 31, Iss 7, Pp - (2020)
Summary: Transcription factors (TFs) play a pivotal role in determining cell states, yet our understanding of the causative relationship between TFs and cell states is limited. Here, we systematically examine the state changes of human pluripotent em
Externí odkaz:
https://doaj.org/article/5e01196c36404cffa69b4492e2cf07ae
Autor:
Rolando Carrisoza-Gaytan, Navin Gupta, Ken Hiratsuka, Katharina Kroll, Ryuji Morizane, Jennifer Lewis, Lisa Satlin
Publikováno v:
Physiology. 38
Kidney organoids derived from human pluripotent stem cells exhibit glomerular- and tubular-like structures. As the technology for culturing organoids advances, the goal of promoting terminal differentiation demands that priority be given to character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::696924afeccbaab5eacb897798ce29ec
https://doi.org/10.1152/physiol.2023.38.s1.5732702
https://doi.org/10.1152/physiol.2023.38.s1.5732702
Autor:
Ken Hiratsuka, Tomoya Miyoshi, Katharina T. Kroll, Navin R. Gupta, M. Todd Valerius, Thomas Ferrante, Michifumi Yamashita, Jennifer A. Lewis, Ryuji Morizane
Publikováno v:
Science Advances. 8
Organoids serve as a novel tool for disease modeling in three-dimensional multicellular contexts. Static organoids, however, lack the requisite biophysical microenvironment such as fluid flow, limiting their ability to faithfully recapitulate disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9617f2b3f53ee055486b85cd1935e728
https://doi.org/10.1126/sciadv.abq0866
https://doi.org/10.1126/sciadv.abq0866
Autor:
Navin Gupta, Takuya Matsumoto, Ken Hiratsuka, Edgar Garcia Saiz, Chengcheng Zhang, Pierre Galichon, Tomoya Miyoshi, Koichiro Susa, Narihito Tatsumoto, Michifumi Yamashita, Ryuji Morizane
Publikováno v:
Sci Transl Med
Kidneys have the capacity for intrinsic repair, preserving kidney architecture with return to a basal state after tubular injury. When injury is overwhelming or repetitive, however, that capacity is exceeded and incomplete repair results in fibrotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c044e3bf76b6f55fe1a402b8b6f47c
https://europepmc.org/articles/PMC9161367/
https://europepmc.org/articles/PMC9161367/
Autor:
Kentaro Fujii, Kazutoshi Miyashita, Isao Kurihara, Ken Hiratsuka, Seiji Sato, Kenichi Yokota, Sakiko Kobayashi, Hirotaka Shibata, Hiroshi Itoh
Publikováno v:
Case Reports in Endocrinology, Vol 2016 (2016)
Glucocorticoid replacement is needed for patients after adrenal surgery for Cushing’s syndrome; however, the adequate dosage is not easily determined. The patient was a 62-year-old woman who has had hypertension for 5 years and presented with heart
Externí odkaz:
https://doaj.org/article/2141ec72ac4c4f7caef0409649b5ba7e
Autor:
Yasuhide, Yoshioka, Keisuke, Anzai, Ryosuke, Kowada, Ken, Hiratsuka, Teppei, Hirayabu, Masashi, Yasuda, Yasuyuki, Ohkawa, Tetsuya, Sato, Mikita, Suyama, Hideki, Yoshida, Masamitsu, Yamaguchi
Publikováno v:
Experimental Cell Research. 420:113307
The CCAAT motif-binding factor NF-Y consists of three different subunits, NF-YA, NF-YB, and NF-YC. Although it is suggested that NF-Y activity is essential for normal tissue homeostasis, survival, and metabolic function, its precise role in lipid met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890fc045fe96a6151a589c2771209a4a
https://doi.org/10.1016/j.yexcr.2022.113307
https://doi.org/10.1016/j.yexcr.2022.113307