Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models

Autor: Wittrahm, Rebekka, Takalo, Mari, Kuulasmaa, Teemu, Mäkinen, Petra M., Mäkinen, Petri, Končarević, Saša, Fartzdinov, Vadim, Selzer, Stefan, Kokkola, Tarja, Antikainen, Leila, Martiskainen, Henna, Kemppainen, Susanna, Marttinen, Mikael, Jeskanen, Heli, Rostalski, Hannah, Rahunen, Eija, Kivipelto, Miia, Ngandu, Tiia, Natunen, Teemu, Lambert, Jean-Charles, Tanzi, Rudolph E., Kim, Doo Yeon, Rauramaa, Tuomas, Herukka, Sanna-Kaisa, Soininen, Hilkka, Laakso, Markku, Pike, Ian, Leinonen, Ville, Haapasalo, Annakaisa, Hiltunen, Mikko

Publikováno v: In Neurobiology of Disease 15 June 2023 182

Organotypic Hippocampal Slice Cultures from Adult Tauopathy Mice and Theragnostic Evaluation of Nanomaterial Phospho-TAU Antibody-Conjugates.

Autor: Kemppainen, Susanna¹ (AUTHOR) mikko.hiltunen@uef.fi, Huber, Nadine² (AUTHOR), Willman, Roosa-Maria¹ (AUTHOR), Zamora, Ana^3,4 (AUTHOR), Mäkinen, Petra¹ (AUTHOR), Martiskainen, Henna¹ (AUTHOR), Takalo, Mari¹ (AUTHOR), Haapasalo, Annakaisa² (AUTHOR), Sobrino, Tomás⁵ (AUTHOR), González Gómez, Manuel Antonio⁶ (AUTHOR), Piñeiro, Yolanda⁶ (AUTHOR), Rivas, José⁶ (AUTHOR), Himmelreich, Uwe⁴ (AUTHOR), Hiltunen, Mikko¹ (AUTHOR)

Publikováno v: Cells (2073-4409). May2023, Vol. 12 Issue 10, p1422. 18p.

Metabolite Signature of Physical Activity and the Risk of Type 2 Diabetes in 7271 Men

Autor: Kemppainen, Susanna Maria, Fernandes Silva, Lilian, Lankinen, Maria Anneli, Schwab, Ursula, Laakso, Markku

Publikováno v: Metabolites, Vol 12, Iss 69, p 69 (2022)
Metabolites

Large population-based studies investigating the association of physical activity (PA) with the metabolite signature contribute significantly to the understanding of the effects of PA on metabolic pathways associated with the risk of type 2 diabetes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::28717b385dd0848a6e633e3006c6fce1
https://www.mdpi.com/2218-1989/12/1/69

Additional file 1 of Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques

Autor: Natunen, Teemu, Martiskainen, Henna, Marttinen, Mikael, Gabbouj, Sami, Hennariikka Koivisto, Kemppainen, Susanna, Kaipainen, Satu, Takalo, Mari, Svobodová, Helena, Luukas Leppänen, Kemiläinen, Benjam, Ryhänen, Simo, Kuulasmaa, Teemu, Rahunen, Eija, Juutinen, Sisko, Mäkinen, Petra, Miettinen, Pasi, Rauramaa, Tuomas, Pihlajamäki, Jussi, Annakaisa Haapasalo, Leinonen, Ville, Tanila, Heikki, Hiltunen, Mikko

Additional file 1: Supplementary Figure S1. a-c. Assessment of soluble Aβ42 and Aβ40 levels as well as Aβ42 and Aβ40 ratio of hippocampal samples from mice with A+ transgene (APPswe/PS1dE9) revealed no significant diet effect. Data are presented

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fcdb57457b081ae256b4fc94e2e3d43

Altered Insulin Signaling in Alzheimer’s Disease Brain – Special Emphasis on PI3K-Akt Pathway

Autor: Gabbouj, Sami, Ryhänen, Simo, Marttinen, Mikael, Wittrahm, Rebekka, Takalo, Mari, Kemppainen, Susanna, Martiskainen, Henna, Tanila, Heikki, Haapasalo, Annakaisa, Hiltunen, Mikko, Natunen, Teemu

Publikováno v: Frontiers in Neuroscience, Vol 13 (2019)

Alzheimer’s disease (AD) and type 2 diabetes (T2D) are both diseases with increasing prevalence in aging populations. T2D, characterized by insulin resistance and defective insulin signaling, is a common co-morbidity and a risk factor for AD, incre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ca649063a7177500672e6fcd8fe9aed5
https://www.frontiersin.org/article/10.3389/fnins.2019.00629/full