Non-kinase off-target inhibitory activities of clinically-relevant kinase inhibitors

Autor: Brauer, Nickolas R., Kempen, Allison L., Hernandez, Delmis, Sintim, Herman O.

Publikováno v: In European Journal of Medicinal Chemistry 5 September 2024 275

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Identification of a Selective FLT3 Inhibitor with Low Activity against VEGFR, FGFR, PDGFR, c‐KIT, and RET Anti‐Targets.

Autor: Akwata, Desmond, Kempen, Allison L., Dayal, Neetu, Brauer, Nickolas R., Sintim, Herman O.

Publikováno v: ChemMedChem; 1/2/2024, Vol. 19 Issue 1, p1-12, 12p

Discovery of imidazo[1,2-b]pyridazine-containing TAK1 kinase inhibitors with excellent activities against multiple myelomaElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3md00415e

Autor: Akwata, Desmond, Kempen, Allison L., Lamptey, Jones, Dayal, Neetu, Brauer, Nickolas R., Sintim, Herman O.

Publikováno v: MedChemComm; 2024, Vol. 15 Issue: 1 p178-192, 15p

Discovery of imidazo[1,2- b ]pyridazine-containing TAK1 kinase inhibitors with excellent activities against multiple myeloma.

Autor: Akwata D; Department of Chemistry, Purdue University 560 Oval Drive West Lafayette IN 47907 USA hsintim@purdue.edu., Kempen AL; Department of Chemistry, Purdue University 560 Oval Drive West Lafayette IN 47907 USA hsintim@purdue.edu., Lamptey J; Department of Chemistry, Purdue University 560 Oval Drive West Lafayette IN 47907 USA hsintim@purdue.edu., Dayal N; Department of Chemistry, Purdue University 560 Oval Drive West Lafayette IN 47907 USA hsintim@purdue.edu., Brauer NR; Department of Chemistry, Purdue University 560 Oval Drive West Lafayette IN 47907 USA hsintim@purdue.edu., Sintim HO; Department of Chemistry, Purdue University 560 Oval Drive West Lafayette IN 47907 USA hsintim@purdue.edu.; Purdue Institute for Drug Discovery 720 Clinic Drive West Lafayette IN 47907 USA.; Purdue Institute for Cancer Research 201 S. University St. West Lafayette IN 47907 USA.

Publikováno v: RSC medicinal chemistry [RSC Med Chem] 2023 Nov 28; Vol. 15 (1), pp. 178-192. Date of Electronic Publication: 2023 Nov 28 (Print Publication: 2024).