Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kemp Mark Ian"'
Autor:
Mark L. Lewis, Charlotte Alice Louise Lane, Blanda Luzia Christa Stammen, David James Rawson, Peter J. Bungay, William A. Million, Stephen Martin Denton, Sharan K. Bagal, Tanya L. Hay, C. Elizabeth Payne, Lisa R. Thompson, Maw Graham Nigel, Cedric Poinsard, Karl Richard Gibson, Kemp Mark Ian, Edward B. Stevens, Melanie S. Glossop
Publikováno v:
ACS Medicinal Chemistry Letters. 6:650-654
Voltage-gated sodium channels, in particular Nav1.8, can be targeted for the treatment of neuropathic and inflammatory pain. Herein, we described the optimization of Nav1.8 modulator series to deliver subtype selective, state, and use-dependent chemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498d91e57ef91a319caeeab504bffe20
https://doi.org/10.1021/acsmedchemlett.5b00059
https://doi.org/10.1021/acsmedchemlett.5b00059
Autor:
Rosemarie Roeloffs, Anthony W Bannon, Adam R. Brown, Alexandre J.C. Loucif, Aristos J. Alexandrou, Anthony J. Kirkup, Mathew D Fuller, Gillian Stockbridge, Edward B. Stevens, David Printzenhoff, Praveen Anand, Steve England, Claire Elizabeth Payne, Uma Anand, Peter J. Bungay, Aaron C. Gerlach, Mark L. Chapman, Kemp Mark Ian, John H. Mahoney, Rebecca L. Prime, Jonathon W Theile, Brett M Antonio, Richard P. Butt, Sharan K. Bagal
Publikováno v:
British Journal of Pharmacology. 172:2654-2670
Background and Purpose NaV1.8 ion channels have been highlighted as important molecular targets for the design of low MW blockers for the treatment of chronic pain. Here, we describe the effects of PF-01247324, a new generation, selective, orally bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc8c0db0b158b8bf6fded6eb148ad000
https://doi.org/10.1111/bph.13092
https://doi.org/10.1111/bph.13092
Autor:
Kemp Mark Ian
This review examines the small molecules described over the past decade as inhibitors of any of the approximately 100 human deubiquitinating enzymes (DUBs). Structures from patent publications as well as from the primary literature are included. Inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3885d9aea9c1503c7b2d8ace3c1b9d4e
https://doi.org/10.1016/bs.pmch.2015.10.002
https://doi.org/10.1016/bs.pmch.2015.10.002
Publikováno v:
Tetrahedron Letters. 41:9323-9326
The reaction of pentacarbonyl[methoxy(2,6-dimethoxyphenyl)methylene]chromium(0) with acetylenic alcohols has been investigated. Reaction protocols have been optimised for rapid and direct access to functionalised γ-, δ-, and e-lactone products poss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d8ec237f9862699185359b55756f606
https://doi.org/10.1016/s0040-4039(00)01684-1
https://doi.org/10.1016/s0040-4039(00)01684-1
Autor:
Kemp Mark Ian
Publikováno v:
Synthesis. 1998:552-556
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d8e9c196ab0c202a0aef9e6e7e52fe3
https://doi.org/10.1055/s-1998-5924
https://doi.org/10.1055/s-1998-5924
Publikováno v:
Cell Biochemistry and Biophysics
Cell Biochemistry and Biophysics; Vol 67
Cell Biochemistry and Biophysics; Vol 67
Covalent post-translational modification of proteins by ubiquitin and ubiquitin-like factors has emerged as a general mechanism to regulate myriad intra-cellular processes. The addition and removal of ubiquitin or ubiquitin-like proteins from factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29e53e41e3fa5262efaf6ef60c5aaee
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4677df52691682a0c2e16f8aea2ce4c
https://doi.org/10.1002/chin.199504073
https://doi.org/10.1002/chin.199504073
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7331b135c607502bcaa4379c5fbd6d3f
https://doi.org/10.1002/chin.199830250
https://doi.org/10.1002/chin.199830250
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d452b21135a751fafd9840709e7cc964
https://doi.org/10.1002/chin.199830153
https://doi.org/10.1002/chin.199830153
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 37(9)
The relationship between rat pharmacokinetics and physicochemical parameters [the partition coefficient between octanol and buffer at pH 7.4 (log D((7.4))) and pK(a)] was studied for a series of tetrahydropyran compounds. Sixteen compounds ranging in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553afb7c3bcf654ccc140ad2bca9e753
https://pubmed.ncbi.nlm.nih.gov/19546239
https://pubmed.ncbi.nlm.nih.gov/19546239