Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Kemin, Tan"'
Autor:
Kemin Tan, Junjian Chen, Yu Kaku, Yi Wang, Luke Donius, Rafiq Ahmad Khan, Xiaolong Li, Hannah Richter, Michael S. Seaman, Thomas Walz, Wonmuk Hwang, Ellis L. Reinherz, Mikyung Kim
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Broadly neutralizing antibodies (bnAbs) against HIV-1 target conserved envelope (Env) epitopes to block viral replication. Here, using structural analyses, we provide evidence to explain why a vaccine targeting the membrane-proximal external
Externí odkaz:
https://doaj.org/article/47bc63ae82264e1ca90081493607b6de
Autor:
Xiaolong Li, Nishant Kumar Singh, David R. Collins, Robert Ng, Angela Zhang, Pedro A. Lamothe-Molina, Peter Shahinian, Shutong Xu, Kemin Tan, Alicja Piechocka-Trocha, Jonathan M. Urbach, Jeffrey K. Weber, Gaurav D. Gaiha, Overbeck Christian Takou Mbah, Tien Huynh, Sophia Cheever, James Chen, Michael Birnbaum, Ruhong Zhou, Bruce D. Walker, Jia-huai Wang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Cytotoxic-T-lymphocyte (CTL) mediated control of HIV-1 is enhanced by targeting highly networked epitopes in complex with human-leukocyte-antigen-class-I (HLA-I). However, the extent to which the presenting HLA allele contributes to this pro
Externí odkaz:
https://doaj.org/article/11d2f05979ea4c16bd9c8f7d0aa55954
Autor:
Kemin Tan, Yuk-Ching Tse-Dinh
Publikováno v:
Cells, Vol 13, Iss 6, p 553 (2024)
Topoisomerases regulate the topological state of cellular genomes to prevent impediments to vital cellular processes, including replication and transcription from suboptimal supercoiling of double-stranded DNA, and to untangle topological barriers ge
Externí odkaz:
https://doaj.org/article/db0332822e9d4a85a11b827cbfa110d1
Autor:
Daniel W. Kneller, Gwyndalyn Phillips, Hugh M. O'Neill, Kemin Tan, Andrzej Joachimiak, Leighton Coates, Andrey Kovalevsky
Publikováno v:
IUCrJ, Vol 7, Iss 6, Pp 1028-1035 (2020)
The emergence of the novel coronavirus SARS-CoV-2 has resulted in a worldwide pandemic not seen in generations. Creating treatments and vaccines to battle COVID-19, the disease caused by the virus, is of paramount importance in order to stop its spre
Externí odkaz:
https://doaj.org/article/6f8288b421504c10acb305f2a86d19ce
Autor:
Kemin Tan, Min Zhou, Robert P. Jedrzejczak, Ruiying Wu, Raul A. Higuera, Dominika Borek, Gyorgy Babnigg, Andrzej Joachimiak
Publikováno v:
Current Research in Structural Biology, Vol 2, Iss , Pp 14-24 (2020)
The recently discovered antibiotic teixobactin is produced by uncultured soil bacteria. The antibiotic inhibits cell wall synthesis of Gram-positive bacteria by binding to precursors of cell wall building blocks, and therefore it is thought to be les
Externí odkaz:
https://doaj.org/article/fa10c6e1bbae4aabb592b0fa413c8b9d
Publikováno v:
Journal of Structural Biology: X, Vol 4, Iss , Pp 100035- (2020)
Knowledge of both apo and holo states of riboswitches aid in elucidating the various mechanisms of ligand-induced conformational “switching” that underpin their gene-regulating capabilities. Previous structural studies on the flavin mononucleotid
Externí odkaz:
https://doaj.org/article/ea43b470fee045968f79a58e7f049ae9
Autor:
Nicole L. Inniss, Travis J. Kochan, George Minasov, Zdzislaw Wawrzak, Changsoo Chang, Kemin Tan, Ludmilla Shuvalova, Olga Kiryukhina, Sergii Pshenychnyi, Ruiying Wu, Ivegeniia Dubrovska, Gyorgy Babnigg, Michael Endres, Wayne F. Anderson, Alan R. Hauser, Andrzej Joachimiak, Karla J. F. Satchell
Publikováno v:
Microbiology Resource Announcements. 12
Klebsiella pneumoniae is a leading cause of antibiotic-resistant-associated deaths in the world. Here, we report the deposition of 14 structures of enzymes from both the core and accessory genomes of sequence type 23 (ST23) K1 hypervirulent K. pneumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87cde8763e9b18ec830fa390aec9271c
https://doi.org/10.1128/mra.01013-22
https://doi.org/10.1128/mra.01013-22
Publikováno v:
Nucleic acids research.
Each catalytic cycle of type IA topoisomerases has been proposed to comprise multistep reactions. The capture of the transport-segment DNA (T-segment) into the central cavity of the N-terminal toroidal structure is an important action, which is prece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa416950bfcabfbc41b933fa0305fa0
https://pubmed.ncbi.nlm.nih.gov/36583363
https://pubmed.ncbi.nlm.nih.gov/36583363
Autor:
Brooke Schuster, Mason R Firpo, Dominique Missiakas, Susan Baker, Hyun Lee, Jennifer K. DeMarco, Marco Vignuzzi, Krysten A. Jones, Bjoern Meyer, Vishnu Nair, Robert Jedrzejczak, Savaş Tay, Bryan C. Dickinson, Jason Botten, Emily A. Bruce, Vincent Mastrodomenico, Amornrat O'Brien, Kenneth E. Palmer, Madaline M. Schmidt, Bryan C. Mounce, Nir Drayman, Christopher B. Brooke, Nicholas S. Heaton, Natalia Maltseva, Saara-Anne Azizi, Glenn Randall, Heather M. Froggatt, Andrzej Joachimiak, Siquan Chen, Rahul S. Kathayat, Steve Dvorkin, Anastasia Tomatsidou, Miguel Ángel Muñoz-Alía, William E. Severson, Kevin Furlong, Vlad Nicolaescu, Kemin Tan, Kyu-yeon Han
Publikováno v:
bioRxiv
There is an urgent need for anti-viral agents that treat SARS-CoV-2 infection. The shortest path to clinical use is repurposing of drugs that have an established safety profile in humans. Here, we first screened a library of 1,900 clinically safe dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d54f7b1f5ec0a952b5543913632dda0
https://doi.org/10.1126/science.abg5827
https://doi.org/10.1126/science.abg5827
Publikováno v:
FEBS lettersReferences. 596(18)
Xylobiose is a prebiotic sugar that has applications in functional foods. This report describes the first X-ray crystallographic structure models of apo and xylobiose-bound forms of a xylobiohydrolase (XBH) from Acetivibrio clariflavus. This xylan-ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0666b43ed530fd92e811532f45158ce3
https://pubmed.ncbi.nlm.nih.gov/35876256
https://pubmed.ncbi.nlm.nih.gov/35876256