Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins.

Autor: Kotliar IB; Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, New York, USA; Tri-Institutional PhD Program in Chemical Biology, New York, New York, USA., Ceraudo E; Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, New York, USA., Kemelmakher-Liben K; Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, New York, USA., Oren DA; Structural Biology Resource Center, The Rockefeller University, New York, New York, USA., Lorenzen E; Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, New York, USA., Dodig-Crnković T; Science for Life Laboratory, Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Solna, Sweden., Horioka-Duplix M; Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, New York, USA., Huber T; Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, New York, USA., Schwenk JM; Science for Life Laboratory, Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Solna, Sweden., Sakmar TP; Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, New York, USA; Department of Neurobiology, Care Sciences and Society, Section for Neurogeriatrics, Karolinska Institutet, Solna, Sweden. Electronic address: Sakmar@rockefeller.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2023 May; Vol. 299 (5), pp. 104664. Date of Electronic Publication: 2023 Mar 30.

Molecular and cellular mechanisms of itch sensation and the anti-itch drug targets.

Autor: Sun M; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China., Chen ZR; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Ding HJ; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China., Feng J; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, 201203, China. fengjing@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. fengjing@simm.ac.cn.

Publikováno v: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2024 Oct 18. Date of Electronic Publication: 2024 Oct 18.