Analyzing the impact of a real-life outbreak simulator on pandemic mitigation: An epidemiological modeling study

Autor: Specht, Ivan, Sani, Kian, Loftness, Bryn C., Hoffman, Curtis, Gionet, Gabrielle, Bronson, Amy, Marshall, John, Decker, Craig, Bailey, Landen, Siyanbade, Tomi, Kemball, Molly, Pickett, Brett E., Hanage, William P., Brown, Todd, Sabeti, Pardis C., Colubri, Andrés

Publikováno v: In Patterns 12 August 2022 3(8)

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Phylogenetic analysis of SARS-CoV-2 in the Boston area highlights the role of recurrent importation and superspreading events.

Autor: Lemieux JE; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA., Siddle KJ; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA., Shaw BM; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA., Loreth C; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA., Schaffner SF; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA., Gladden-Young A; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA., Adams G; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA., Fink T; Massachusetts Department of Public Health, Boston, MA, USA., Tomkins-Tinch CH; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA., Krasilnikova LA; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA., DeRuff KC; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA., Rudy M; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA., Bauer MR; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Harvard Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA., Lagerborg KA; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Harvard Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA., Normandin E; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Chapman SB; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA., Reilly SK; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA., Anahtar MN; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Lin AE; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA., Carter A; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA., Myhrvold C; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA., Kemball ME; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Chaluvadi S; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA., Cusick C; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA., Flowers K; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA., Neumann A; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA., Cerrato F; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA., Farhat M; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Division of Pulmonary and Critical Care, Massachusetts General Hospital, Boston, MA, USA., Slater D; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA., Harris JB; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Branda J; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Hooper D; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA., Gaeta JM; lnstitute for Research, Quality, and Policy in Homeless Health Care, Boston Health Care for the Homeless Program, Boston, MA, USA.; Section of General Internal Medicine, Boston University Medical Center, Boston., Baggett TP; lnstitute for Research, Quality, and Policy in Homeless Health Care, Boston Health Care for the Homeless Program, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston.; Department of Medicine, Harvard Medical School, Boston, MA, USA., O'Connell J; lnstitute for Research, Quality, and Policy in Homeless Health Care, Boston Health Care for the Homeless Program, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Gnirke A; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA., Lieberman TD; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; lnstitute for Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Philippakis A; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA., Burns M; Massachusetts Department of Public Health, Boston, MA, USA., Brown CM; Massachusetts Department of Public Health, Boston, MA, USA., Luban J; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, 02115, USA., Ryan ET; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Turbett SE; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., LaRocque RC; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hanage WP; Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA., Gallagher GR; Massachusetts Department of Public Health, Boston, MA, USA., Madoff LC; Massachusetts Department of Public Health, Boston, MA, USA.; University of Massachusetts Medical School, Infectious Diseases and Immunology, Worcester, MA 01655., Smole S; Massachusetts Department of Public Health, Boston, MA, USA., Pierce VM; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Pediatric Infectious Disease Unit, MassGeneral Hospital for Children, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA., Rosenberg E; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Sabeti PC; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, 02115, USA.; Howard Hughes Medical Institute, 4000 Jones Bridge Rd, Chevy Chase, MD 20815., Park DJ; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA., Maclnnis BL; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, 02115, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2020 Aug 25. Date of Electronic Publication: 2020 Aug 25.