Zobrazeno 1 - 10 of 75 pro vyhledávání: '"Kemal Yelekçi"'
1
Akademický článek
Design, synthesis, molecular modeling, and bioactivity evaluation of 1,10-phenanthroline and prodigiosin (Ps) derivatives and their Copper(I) complexes against mTOR and HDAC enzymes as highly potent and effective new anticancer therapeutic drugs
Autor: M. Mustafa Cetin, Wenjing Peng, Daniel Unruh, Michael F. Mayer, Yehia Mechref, Kemal Yelekci
Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)
Breast cancer is the second type of cancer with a high probability of brain metastasis and has always been one of the main problems of breast cancer research due to the lack of effective treatment methods. Demand for developing an effective drug agai
Externí odkaz: https://doaj.org/article/5c8911b6df1345e1ae0549dacfa83ab4
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2
Akademický článek
Repurposing of known drugs from multiple libraries to identify novel and potential selective inhibitors of HDAC6 via in silico approach and molecular modeling
Autor: Naz Mina Mert, Buse Erdogan, Kemal Yelekçi
Publikováno v: Heliyon, Vol 10, Iss 15, Pp e35020- (2024)
Histone deacetylase 6 (HDAC6, Class IIb) is a promising target for anticancer drugs. So far, few nonselective HDAC inhibitors have received regulatory approval as anticancer agents. However, they are associated with cell toxicity. Thus, isoform-selec
Externí odkaz: https://doaj.org/article/8e8346387d1f4bd9b37223dccb428c0b
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3
Akademický článek
Synthesis, Molecular Docking and Anticancer Activity of Diflunisal Derivatives as Cyclooxygenase Enzyme Inhibitors
Autor: Göknil Pelin Coşkun, Teodora Djikic, Taha Bartu Hayal, Nezaket Türkel, Kemal Yelekçi, Fikrettin Şahin, Ş. Güniz Küçükgüzel
Publikováno v: Molecules, Vol 23, Iss 8, p 1969 (2018)
Cyclooxygenase enzymes play a vital role in inflammatory pathways in the human body. Apart from their relation with inflammation, the additional involvement of COX-2 enzyme with cancer activity was recently discovered. In some cancer types the level
Externí odkaz: https://doaj.org/article/b1e7e91058294a1dbb0abd7b05742faa
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6
Molecular modeling studies of some phytoligands from Ficus sycomorus fraction as potential inhibitors of cytochrome CYP6P3 enzyme of Anopheles coluzzii
Autor: Abba Babandi, Chioma A. Anosike, Lawrence U.S. Ezeanyika, Kemal Yelekçi, Abdullahi Ibrahim Uba
Publikováno v: Jordan Journal of Pharmaceutical Sciences. 15:258-275
The major obstacle in controlling malaria is the mosquito’s resistance to insecticides, including pyrethroids. The resistance is mainly due to the over-expression of detoxification enzymes such as cytochromes. Insecticides tolerance can be reduced
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da50ed58e83ce85bf7fdf8820ac9f02b
https://doi.org/10.35516/jjps.v15i2.324
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9
Computational Chemistry and Molecular Modeling of Reversible MAO Inhibitors
Autor: Kemal, Yelekçi, Safiye Sağ, Erdem
Publikováno v: Methods in molecular biology (Clifton, N.J.). 2558
Proper elucidation of drug-target interaction is one of the most significant steps at the early stages of the drug development research. Computer-aided drug design tools have substantial contribution to this stage. In this chapter, we specifically co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c97d61a298095964e1eb631a2bbb1294
https://pubmed.ncbi.nlm.nih.gov/36169867
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