Zobrazeno 1 - 10 of 105 pro vyhledávání: '"Kemal Yelekçi"'
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Akademický článek
Repurposing of known drugs from multiple libraries to identify novel and potential selective inhibitors of HDAC6 via in silico approach and molecular modeling
Autor: Naz Mina Mert, Buse Erdogan, Kemal Yelekçi
Publikováno v: Heliyon, Vol 10, Iss 15, Pp e35020- (2024)
Histone deacetylase 6 (HDAC6, Class IIb) is a promising target for anticancer drugs. So far, few nonselective HDAC inhibitors have received regulatory approval as anticancer agents. However, they are associated with cell toxicity. Thus, isoform-selec
Externí odkaz: https://doaj.org/article/8e8346387d1f4bd9b37223dccb428c0b
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4
Molecular modeling studies of some phytoligands from Ficus sycomorus fraction as potential inhibitors of cytochrome CYP6P3 enzyme of Anopheles coluzzii
Autor: Abba Babandi, Chioma A. Anosike, Lawrence U.S. Ezeanyika, Kemal Yelekçi, Abdullahi Ibrahim Uba
Publikováno v: Jordan Journal of Pharmaceutical Sciences. 15:258-275
The major obstacle in controlling malaria is the mosquito’s resistance to insecticides, including pyrethroids. The resistance is mainly due to the over-expression of detoxification enzymes such as cytochromes. Insecticides tolerance can be reduced
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da50ed58e83ce85bf7fdf8820ac9f02b
https://doi.org/10.35516/jjps.v15i2.324
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7
Computational Chemistry and Molecular Modeling of Reversible MAO Inhibitors
Autor: Kemal, Yelekçi, Safiye Sağ, Erdem
Publikováno v: Methods in molecular biology (Clifton, N.J.). 2558
Proper elucidation of drug-target interaction is one of the most significant steps at the early stages of the drug development research. Computer-aided drug design tools have substantial contribution to this stage. In this chapter, we specifically co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c97d61a298095964e1eb631a2bbb1294
https://pubmed.ncbi.nlm.nih.gov/36169867
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9
Screening of novel and selective inhibitors for neuronal nitric oxide synthase (nNOS) via structure-based drug design techniques
Autor: Sarah Boumezber, Kemal Yelekçi
Publikováno v: Journal of biomolecular structuredynamics.
NO, or nitric oxide, is produced by a family of enzymes called nitric oxide synthase (NOS) from L-arginine. NO regulates many physiological functions such as smooth muscle relaxation, immune defense, and memory function. The overproduction of NO by t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d651b001997f4471a1f59da58ef0b4
https://pubmed.ncbi.nlm.nih.gov/35322764
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10
Synthesis, in silico studies and cytotoxicity evaluation of novel 1,3,4-oxadiazole derivatives designed as potential mPGES-1 inhibitors
Autor: Merve Duracık, Kemal Yelekçi, Ozlem Bingol Ozakpinar, Chang-Guo Zhan, Gizem Erensoy, Ammar D. Elmezayen, Kai Ding, İlkay Küçükgüzel
Publikováno v: Journal of Research in Pharmacy. 24:436-451
A series of new 1,3,4-oxadizole derivatives containing thioether group, has been synthesized to investigate their mPGES-1 inhibitory activities. The synthesized compounds were also evaluated for their anticancer and COX-1/2 inhibitory activities. All
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e572b70476cc8bae6f5e0b6d05b5ea60
https://doi.org/10.35333/jrp.2020.187
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