Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Kelvyn M. L. Rocha"'
Publikováno v:
Molecules, Vol 29, Iss 17, p 4254 (2024)
Four afatinib derivatives were designed and modeled. These derivatives were compared to the known tyrosine-kinase inhibitors in treating Chronic Myeloid Leukemia, i.e., imatinib and ponatinib. The molecules were evaluated through computational method
Externí odkaz:
https://doaj.org/article/fb230ff8778a452a8bc281206484270b
Publikováno v:
Journal of Molecular Modeling. 27
Chronic myeloid leukemia (CML) is a pathological condition associated with the uncontrolled proliferation of white blood cells and respective loss of function. Imatinib was the first drug that could effectively treat this condition, but its use is hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::636919837b7b0ee9cb42cd440c7894d9
https://doi.org/10.1007/s00894-021-04925-8
https://doi.org/10.1007/s00894-021-04925-8
Publikováno v:
Anais do VIII Simpósio de Estrutura Eletrônica e Dinâmica Molecular.
Chronic myeloid leukemia is a type of cancer which affects hematopoetic cells, causing excessive proliferation of white blood cells which eventually leads to loss of function and resistance to apoptosis (stage known as acute leukemia). Researchers ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9fb9e1dc689dc9cb862404100f3a66e
https://doi.org/10.21826/viiiseedmol2020151
https://doi.org/10.21826/viiiseedmol2020151