Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Kelvin W Gee"'
Autor:
David J Titus, Timothy Johnstone, Nathan H Johnson, Sidney H London, Meghana Chapalamadugu, Derk Hogenkamp, Kelvin W Gee, Coleen M Atkins
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223180 (2019)
Cognitive impairments are a common consequence of traumatic brain injury (TBI). The hippocampus is a subcortical structure that plays a key role in the formation of declarative memories and is highly vulnerable to TBI. The α7 nicotinic acetylcholine
Externí odkaz:
https://doaj.org/article/3f694b47493b4a208cd553c02152427b
Publikováno v:
Neurobiology of Stress, Vol 12, Iss , Pp - (2020)
In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR). These reports were followed by the discovery that
Externí odkaz:
https://doaj.org/article/8b28a0f5a73447948d30996d5d43b0e6
Autor:
Timothy B. C. Johnstone, Hilary S. McCarren, Jay Spampanato, F. Edward Dudek, John H. McDonough, Derk Hogenkamp, Kelvin W. Gee
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Seizures induced by organophosphorus nerve agent exposure become refractory to treatment with benzodiazepines because these drugs engage synaptic γ-aminobutyric acid-A receptors (GABAARs) that rapidly internalize during status epilepticus (SE). Extr
Externí odkaz:
https://doaj.org/article/25d1ae99c446488ba9de5d89a56a1187
Publikováno v:
Neurobiology of Stress, Vol 12, Iss, Pp-(2020)
In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR). These reports were followed by the discovery that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19632fe64704dfe534091635a399c274
http://www.sciencedirect.com/science/article/pii/S2352289519300591
http://www.sciencedirect.com/science/article/pii/S2352289519300591
Autor:
Doodipala Samba Reddy, Derk J. Hogenkamp, Gunasekaran Ramanathan, Timothy B C Johnstone, Ryan F. Yoshimura, Chase M. Carver, Kelvin W. Gee
Publikováno v:
Epilepsy & Behavior. 82:57-63
Objective Subunit-specific positive allosteric modulators (PAMs) of gamma-aminobutyric acid-A (GABA-A) receptors are commonly used to uncover the role of GABA-A receptor isoforms in brain function. Recently, we have designed novel PAMs selective for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::464f780901820a2aebec6eaf705d07f9
https://doi.org/10.1016/j.yebeh.2018.02.020
https://doi.org/10.1016/j.yebeh.2018.02.020
Autor:
Narielle L. Ayala, Minhtam B. Tran, Ryan F. Yoshimura, Timothy B C Johnstone, Andrew J. Dunnigan, Kelvin W. Gee, Timothy K. Gee, Derk J. Hogenkamp
Publikováno v:
Neuropharmacology. 126:38-47
Autism spectrum disorder (ASD) is associated with two core symptoms (social communication deficits and stereotyped repetitive behaviors) in addition to a number of comorbidities. There are no FDA-approved drugs for the core symptoms and the changes t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b11371a1c67315f804e5ecc4896861fd
https://doi.org/10.1016/j.neuropharm.2017.08.029
https://doi.org/10.1016/j.neuropharm.2017.08.029
Publikováno v:
Neurobiology of Stress
In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR). These reports were followed by the discovery that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::edea4e6cd234a698752ad2b82527aa62
https://pubmed.ncbi.nlm.nih.gov/32435660
https://pubmed.ncbi.nlm.nih.gov/32435660
Autor:
John H. McDonough, Derk J. Hogenkamp, Hilary S. McCarren, Timothy B C Johnstone, Kelvin W. Gee, F. Edward Dudek, Jay Spampanato
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 10 (2019)
Frontiers in Pharmacology, Vol 10 (2019)
Seizures induced by organophosphorus nerve agent exposure become refractory to treatment with benzodiazepines because these drugs engage synaptic γ-aminobutyric acid-A receptors (GABAARs) that rapidly internalize during status epilepticus (SE). Extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2a3410da40e39e8052d60d7c68080c
http://europepmc.org/articles/PMC6543275
http://europepmc.org/articles/PMC6543275
Autor:
Chaoling Qu, Jennifer Y. Xie, David J. Wasiak, Kelvin W. Gee, Timothy B C Johnstone, Frank Porreca, Derk J. Hogenkamp
Publikováno v:
Pain, vol 160, iss 1
Chronic neuropathic pain may be caused, in part, by loss of inhibition in spinal pain processing pathways due to attenuation of local GABAergic tone. Nociception and nocifensive behaviors are reduced after enhancement of tonically activated extrasyna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0880e0be16f4ebda5ad6174bfd207fef
https://escholarship.org/uc/item/71k240r2
https://escholarship.org/uc/item/71k240r2
Autor:
David J. Titus, Timothy B C Johnstone, Nathan H. Johnson, Derk J. Hogenkamp, Coleen M. Atkins, Kelvin W. Gee, Sidney H. London, Meghana Chapalamadugu
Publikováno v:
PloS one, vol 14, iss 10
PLoS ONE, Vol 14, Iss 10, p e0223180 (2019)
PLoS ONE
PLoS ONE, Vol 14, Iss 10, p e0223180 (2019)
PLoS ONE
Cognitive impairments are a common consequence of traumatic brain injury (TBI). The hippocampus is a subcortical structure that plays a key role in the formation of declarative memories and is highly vulnerable to TBI. The α7 nicotinic acetylcholine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65a037999604a87aee4031ccfe3b8c9
https://escholarship.org/uc/item/2tk1w1pk
https://escholarship.org/uc/item/2tk1w1pk