Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kelvin W, Li"'
Autor:
Eric J. Lawitz, Kelvin W. Li, Edna Nyangau, Tyler John Field, Jen-Chieh Chuang, Andrew Billin, Lulu Wang, Ya Wang, Ryan S. Huss, Chuhan Chung, G. Mani Subramanian, Robert P. Myers, Marc K. Hellerstein
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 9, Pp 100250- (2022)
Abstract: De novo lipogenesis (DNL) converts carbon substrates to lipids. Increased hepatic DNL could contribute to pathogenic liver triglyceride accumulation in nonalcoholic steatohepatitis (NASH) and therefore may be a potential target for pharmaco
Externí odkaz:
https://doaj.org/article/4ec0975a815c4b149a578efd36195ac9
Autor:
Veronika I Zarnitsyna, Rama S Akondy, Hasan Ahmed, Donald J McGuire, Vladimir G Zarnitsyn, Mia Moore, Philip L F Johnson, Rafi Ahmed, Kelvin W Li, Marc K Hellerstein, Rustom Antia
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1009468 (2021)
Understanding how immunological memory lasts a lifetime requires quantifying changes in the number of memory cells as well as how their division and death rates change over time. We address these questions by using a statistically powerful mixed-effe
Externí odkaz:
https://doaj.org/article/d833a13fe7e34b38b5d1e8330ab10a2f
Autor:
Richard H. Carson, Charlotte R. Lewis, Mercede N. Erickson, Anna P. Zagieboylo, Bradley C. Naylor, Kelvin W. Li, Paul B. Farnsworth, John C. Price
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 9, Pp 1884-1892 (2017)
Compartmentalization of metabolism into specific regions of the cell, tissue, and organ is critical to life for all organisms. Mass spectrometric imaging techniques have been valuable in identifying and quantifying concentrations of metabolites in sp
Externí odkaz:
https://doaj.org/article/30b091be06e7478ab98d722fe439f15c
Autor:
Qizhi, Tang, Joey, Leung, Yani, Peng, Alberto, Sanchez-Fueyo, Juan-Jose, Lozano, Alice, Lam, Karim, Lee, John R, Greenland, Marc, Hellerstein, Mark, Fitch, Kelvin W, Li, Jonathan H, Esensten, Amy L, Putnam, Angela, Lares, Vinh, Nguyen, Weihong, Liu, Nancy D, Bridges, Jonah, Odim, Anthony J, Demetris, Josh, Levitsky, Timucin, Taner, Sandy, Feng
Publikováno v:
Science translational medicine. 14(669)
Promoting immune tolerance to transplanted organs can minimize the amount of immunosuppressive drugs that patients need to take, reducing lifetime risks of mortality and morbidity. Regulatory T cells (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::441ee33907e08c5d3bc4148be1a5c3ae
https://pubmed.ncbi.nlm.nih.gov/36322627
https://pubmed.ncbi.nlm.nih.gov/36322627
Autor:
Hector Palacios, Rohit Setlem, Marc K. Hellerstein, Shanmugasundaram Nallasamy, Kelvin W. Li, Mala Mahendroo, Mahalakshmi Shankaran, Edward Cao, Mariano Colon Caraballo
Publikováno v:
Biol Reprod
During gestation, the female reproductive tract must maintain pregnancy while concurrently preparing for parturition. Here, we explore the transitions in gene expression and protein turnover (fractional synthesis rates [FSR]) by which the cervix impl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27274231c1ab217e7b3e5d9ecd30776
https://doi.org/10.1093/biolre/ioab144
https://doi.org/10.1093/biolre/ioab144
Autor:
Marc K. Hellerstein, Patrick Kelly, Kiran Dole, Lars Johansson, Kelvin W. Li, Eric Q. Wu, Carine Beysen, Terry E O’Reilly, Marcus Hompesch, Linda Morrow, Wei Lu, Patricia Schroeder, Julie Brevard, Maria D. Ribadeneira
Publikováno v:
Diabetes, Obesity & Metabolism
Aims To assess the therapeutic potential of fatty acid synthase (FASN) inhibition with FT‐4101, a potent, selective, orally bioavailable, small‐molecule by (a) evaluating the dose−response of single FT‐4101 doses (3, 6 and 9 mg) on hepatic de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a61fcfec38047f5f2606d94d67ebcaf
https://doi.org/10.1111/dom.14272
https://doi.org/10.1111/dom.14272
Autor:
David A. Beebe, Gregg D. Cappon, Michelle Clasquin, Marc K. Hellerstein, Norimitsu Shirai, William J. Reagan, Zhongyuan Sun, Katherine Hales, Gabriele E. Sonnenberg, Jeffrey A. Pfefferkorn, Theodore J. Schmahai, Nicholas B. Vera, Marcy Matthews, Trenton T. Ross, Clare Buckeridge, Enida Ziso Qejvanaj, Kenneth L. Kelly, Shoh Asano, Santos Carvajal-Gonzalez, William P. Esler, Paul A. Amor, Kelvin W. Li, Arthur Bergman
Publikováno v:
Nature Metabolism. 2:1163-1178
Acetyl-CoA carboxylase (ACC) catalyses the first step of de novo lipogenesis (DNL). Pharmacologic inhibition of ACC has been of interest for therapeutic intervention in a wide range of diseases. We demonstrate here that ACC and DNL are essential for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37212bb75eaf160e3e8857af5cd7c6c9
https://doi.org/10.1038/s42255-020-00272-9
https://doi.org/10.1038/s42255-020-00272-9
Autor:
Catherine C. Cohen, Kelvin W. Li, Adina L. Alazraki, Carine Beysen, Carissa A. Carrier, Rebecca L. Cleeton, Mohamad Dandan, Janet Figueroa, Jack Knight-Scott, Cynthia J. Knott, Kimberly P. Newton, Edna M. Nyangau, Claude B. Sirlin, Patricia A. Ugalde-Nicalo, Jean A. Welsh, Marc K. Hellerstein, Jeffrey B. Schwimmer, Miriam B. Vos
Publikováno v:
The Journal of clinical investigation, vol 131, iss 24
J Clin Invest
J Clin Invest
BACKGROUNDHepatic de novo lipogenesis (DNL) is elevated in nonalcoholic fatty liver disease (NAFLD). Improvements in hepatic fat by dietary sugar reduction may be mediated by reduced DNL, but data are limited, especially in children. We examined the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2043cd2ccea0f3fdd41d9d78068c143
https://doi.org/10.1172/jci150996
https://doi.org/10.1172/jci150996
Autor:
Claire L Emson, Sarah Fitzmaurice, Glen Lindwall, Kelvin W Li, Marc K Hellerstein, Howard I Maibach, Wilson Liao, Scott M Turner
Publikováno v:
Clinical and Translational Medicine, Vol 2, Iss 1, Pp n/a-n/a (2013)
Abstract Background Previous studies of epidermal kinetics in psoriasis have relied on invasive biopsy procedures or the use of radioactive labels. We previously developed a non‐invasive method for measuring keratin synthesis in human skin using de
Externí odkaz:
https://doaj.org/article/1dc031fedfa64a8d9d9b4f0a3b8607ca
Autor:
John C. Price, Bradley C. Naylor, Paul B. Farnsworth, Anna P. Zagieboylo, Mercede N. Erickson, Richard H. Carson, Charlotte R. Lewis, Kelvin W. Li
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 9, Pp 1884-1892 (2017)
Compartmentalization of metabolism into specific regions of the cell, tissue, and organ is critical to life for all organisms. Mass spectrometric imaging techniques have been valuable in identifying and quantifying concentrations of metabolites in sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0444af31d7d00d50e617fea586586fa
http://www.sciencedirect.com/science/article/pii/S0022227520339584
http://www.sciencedirect.com/science/article/pii/S0022227520339584