Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Kelvin Stott"'
1
N-Methylated Peptide Inhibitors of β-Amyloid Aggregation and Toxicity. Optimization of the Inhibitor Structure
Autor: Hozefa Amijee, Jody M. Mason, Andrew J. Doig, Kelvin Stott, Nicoleta Kokkoni
Publikováno v: Biochemistry. 45:9906-9918
The key pathogenic event in the onset of Alzheimer's disease (AD) is believed to be the aggregation of the beta-amyloid (Abeta) peptide into toxic oligomers. Molecules that interfere with this process may therefore act as therapeutic agents for the t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d5d73b0605ea19c978792d4d115414
https://doi.org/10.1021/bi060837s
Zobrazit plný text záznamu
3
Solution Studies of Chymotrypsin Inhibitor-2 Glutamine Insertion Mutants Show No Interglutamine Interactions
Autor: Rodrigo J. Carbajo, Duncan J. Gordon-Smith, Kelvin Stott, David Neuhaus
Publikováno v: Biochemical and Biophysical Research Communications. 280:855-860
Mutants of chymotrypsin inhibitor protein 2 have previously been studied in which 4 or 10 glutamine residues were inserted into the inhibitory loop of the protein between residues 59 and 60, as potential models for the behaviour of glutamine tracts i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0558c5d2c3b5c5d26a8cd6bc45dd4e47
https://doi.org/10.1006/bbrc.2000.4196
Zobrazit plný text záznamu
4
Incorporation of glutamine repeats makes protein oligomerize: implications for neurodegenerative diseases
Autor: P.J.G. Butler, Kelvin Stott, Max F. Perutz, Jonathan M. Blackburn
Publikováno v: Proceedings of the National Academy of Sciences. 92:6509-6513
Many transcription factors and some other proteins contain glutamine repeats; their abnormal expansion has been linked to several dominantly inherited neuro-degenerative diseases. Having found that poly(L-glutamine) alone forms beta-strands held toge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9cacbefd5daa4cc443f43210dd0a7c
https://doi.org/10.1073/pnas.92.14.6509
Zobrazit plný text záznamu
5
P4–300: N–methylated peptide inhibitors of β–amyloid aggregation
Autor: Hozefa Amijee, Andrew J. Doig, Mark Treherne, Joanna Bottomley, Nicoleta Kokkoni, Kelvin Stott, Jody M. Mason, David I.C. Scopes
Publikováno v: Alzheimer's & Dementia. 2
Background: The key pathogenic event in the onset of Alzheimer’s disease (AD) is believed to be the aggregation of the β-amyloid peptide (Aβ) into toxic oligomers. Molecules that interfere with this process may therefore act as therapeutic agents
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6d281fd7fe47368d292c964b59adcc2
https://doi.org/10.1016/j.jalz.2006.05.2039
Zobrazit plný text záznamu
6
Design strategies for anti-amyloid agents
Autor: Nicoleta Kokkoni, Andrew J. Doig, Kelvin Stott, Jody M. Mason
Publikováno v: Current opinion in structural biology. 13(4)
Numerous diseases have been linked to a common pathogenic process called amyloidosis, whereby proteins or peptides clump together in the brain or body to form toxic soluble oligomers and/or insoluble fibres. An attractive strategy to develop therapie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af7a8f569ad3300b60df81eb0222d6e0
https://pubmed.ncbi.nlm.nih.gov/12948784
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje