Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Kelvin P. Lee"'
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Multiple myeloma (MM) is an incapacitating hematological malignancy characterized by accumulation of cancerous plasma cells in the bone marrow (BM) and production of an abnormal monoclonal protein (M-protein). The BM microenvironment has a key role i
Externí odkaz:
https://doaj.org/article/93f18b0737f542da94b3ffea6fb665c9
Autor:
Peter Bloomingdale, Cristina Meregalli, Kevin Pollard, Annalisa Canta, Alessia Chiorazzi, Giulia Fumagalli, Laura Monza, Eleonora Pozzi, Paola Alberti, Elisa Ballarini, Norberto Oggioni, Louise Carlson, Wensheng Liu, Mehrnoosh Ghandili, Tracey A. Ignatowski, Kelvin P. Lee, Michael J. Moore, Guido Cavaletti, Donald E. Mager
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Chemotherapy-induced peripheral neurotoxicity is a common dose-limiting side effect of several cancer chemotherapeutic agents, and no effective therapies exist. Here we constructed a systems pharmacology model of intracellular signaling in peripheral
Externí odkaz:
https://doaj.org/article/1ccf464a944a4141a28474e8a0809c1d
Autor:
Seyeon Bae, Peter Sang Uk Park, Yeji Lee, Se Hwan Mun, Eugenia Giannopoulou, Takayuki Fujii, Kelvin P. Lee, Sara Nunes Violante, Justin R. Cross, Kyung-Hyun Park-Min
Publikováno v:
Cell Reports, Vol 35, Iss 11, Pp 109264- (2021)
Summary: MYC activates different metabolic programs in a cell-type- and cell-status-dependent manner. However, the role of MYC in inflammatory macrophages has not yet been determined. Metabolic and molecular analyses reveal that MYC, but not hypoxia
Externí odkaz:
https://doaj.org/article/f1316364c7fb416295e88be27e4869c4
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Multiple myeloma is a clonal disease of long-lived plasma cells and is the second most common hematological cancer behind Non-Hodgkin’s Lymphoma. Malignant transformation of plasma cells imparts the ability to proliferate, causing harmful lesions i
Externí odkaz:
https://doaj.org/article/2dcee3535dcb4967b05d209732683bb0
Autor:
Catherine M. Gavile, Benjamin G. Barwick, Scott Newman, Paola Neri, Ajay K. Nooka, Sagar Lonial, Kelvin P. Lee, Lawrence H. Boise
Publikováno v:
Blood Advances, Vol 1, Iss 25, Pp 2307-2319 (2017)
Abstract: Although prognosis for patients with multiple myeloma has improved over the past decade, research toward discovery of new therapeutic avenues is important and could lead to a cure for this plasma cell malignancy. Here we show that blocking
Externí odkaz:
https://doaj.org/article/d11b68126fcf43bab9a5435fdb2b8e77
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Durable humoral immunity is dependent upon the generation of antigen-specific antibody titers, produced by non-proliferating bone marrow resident long-lived plasma cells (LLPC). Longevity is the hallmark of LLPC, but why and how they survive and func
Externí odkaz:
https://doaj.org/article/7ec6c308040a41828b8d61c398e70a92
Autor:
Wei Du, Hemn Mohammadpour, Rachel E. O'Neill, Sandeep Kumar, Chuan Chen, Michelle Qiu, Lin Mei, Jingxin Qiu, Philip L. McCarthy, Kelvin P. Lee, Xuefang Cao
Publikováno v:
OncoImmunology, Vol 7, Iss 3 (2018)
Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapy for hematologic malignancies. Donor T cells are able to eliminate residual tumor cells after allo-HCT, producing the beneficial graft-versus-tumor (GVT) effect
Externí odkaz:
https://doaj.org/article/a160859fd18b4268993c35925024d26e
Autor:
Paul K. Wallace, Lei Wei, Philip L. McCarthy, Theresa Hahn, Almuth Maria Anni Merz, Jesse Luce, Qiang Hu, Prashant Singh, Maximilian Merz, Megan M. Herr, Song Liu, Ahmed Belal, Ronald A. Alberico, Joseph D. Tario, AnneMarie W. Block, Cherie Rondeau, Kelvin P. Lee, Hemn Mohammadpour, Sean T. Glenn, Jens Hillengass, Kimberly Celotto, Jie Wang
Publikováno v:
Blood Advances. 7:718-733
Introduction: Therapy and immune mediated processes are associated with clonal evolution in multiple myeloma (MM). In this study, we performed whole-exome sequencing (WES) and single cell RNA sequencing (scRNA-seq) on plasma cells (PC) from bone marr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210082d481787055ba7eb1ec3f09c12d
https://doi.org/10.1182/bloodadvances.2022007457
https://doi.org/10.1182/bloodadvances.2022007457
Autor:
Caryn Lerman, Chanita Hughes-Halbert, Mary Falcone, David M Gosky, Roy A Jensen, Kelvin P Lee, Edith Mitchell, Kunle Odunsi, Jennifer W Pegher, Elisa Rodriguez, Yolanda Sanchez, Reuben Shaw, George Weiner, Cheryl L Willman
Publikováno v:
JNCI: Journal of the National Cancer Institute. 114:1214-1221
The capacity and diversity of the oncology leadership workforce has not kept pace with the emerging needs of our increasingly complex cancer centers and the spectrum of challenges our institutions face in reducing the cancer burden in diverse catchme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb240a798e5205b4cf6a2ea196b811b9
https://doi.org/10.1093/jnci/djac121
https://doi.org/10.1093/jnci/djac121
Supplementary Data from PDZ Proteins SCRIB and DLG1 Regulate Myeloma Cell Surface CD86 Expression, Growth, and Survival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620f024385283d8089fde55769c80a12
https://doi.org/10.1158/1541-7786.22527803
https://doi.org/10.1158/1541-7786.22527803
