Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Kelvin L, Billingsley"'
Autor:
Manuel Mendoza, UyenPhuong Tran, Grace C. Zhang, Jeffrey Leister, Kyle To, Theodore Malepeai-Tofaeono, Alison E. Ondrus, Kelvin L. Billingsley
Publikováno v:
ACS medicinal chemistry letters. 13(7)
The Gli transcription factors within the Hedgehog (Hh) signaling pathway play essential roles in human development. However, the reactivation of Gli proteins in adult tissue is tumorigenic and drives the progression of several cancers, including the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::560773fa1a5112ec763a4f3054da537e
https://pubmed.ncbi.nlm.nih.gov/35859880
https://pubmed.ncbi.nlm.nih.gov/35859880
Autor:
Ralph J. DeBerardinis, Junjie Li, Jeffry R. Alger, Kelvin L. Billingsley, Jae Mo Park, Evan LaGue, Manuel Mendoza, Jun Chen, Edward P. Hackett, Chendong Yang, Ian R. Corbin
Publikováno v:
Anal Sens
The interplay between glycolysis and gluconeogenesis is central to carbohydrate metabolism. Here, we describe novel methods to assess carbohydrate metabolism using [(13)C]-probes derived from glycerate, a molecule whose metabolic fate in mammals rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b667ebedca53d205179088e1db2ed0e8
https://doi.org/10.1002/anse.202100034
https://doi.org/10.1002/anse.202100034
Autor:
Vamsidihara Vemireddy, Kelvin L. Billingsley, Manuel Mendoza, Robert Bachoo, Evan LaGue, Edward P. Hackett, Jae Mo Park, Bhavya R. Shah, Bingbing Cheng, Rajiv Chopra, Chenchen Bing
Publikováno v:
ACS Chemical Neuroscience. 12:2820-2828
Transient disruption of the blood-brain barrier (BBB) with focused ultrasound (FUS) is an emerging clinical method to facilitate targeted drug delivery to the brain. The focal noninvasive disruption of the BBB can be applied to promote the local deli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46d9e191bdbbd27cd0b5d969f7608c1c
https://doi.org/10.1021/acschemneuro.1c00197
https://doi.org/10.1021/acschemneuro.1c00197
Autor:
Edward P, Hackett, Bhavya R, Shah, Bingbing, Cheng, Evan, LaGue, Vamsidihara, Vemireddy, Manuel, Mendoza, Chenchen, Bing, Robert M, Bachoo, Kelvin L, Billingsley, Rajiv, Chopra, Jae Mo, Park
Publikováno v:
ACS Chem Neurosci
Transient disruption of the blood-brain barrier (BBB) with focused ultrasound (FUS) is an emerging clinical method to facilitate targeted drug delivery to the brain. The focal noninvasive disruption of the BBB can be applied to promote local delivery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33c33fb8c58c927a683bf09cfa0a231c
https://pubmed.ncbi.nlm.nih.gov/34291630
https://pubmed.ncbi.nlm.nih.gov/34291630
Publikováno v:
Tetrahedron. 75:4337-4342
The first total synthesis of (−)-indolactam I (1) is reported. An efficient synthetic route was established to furnish the natural product in 8 steps. This strategy employed a copper-catalyzed amino acid arylation, peptide coupling, and Lewis acid-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daac596cb2678b8b94648f9fe1c748d9
https://doi.org/10.1016/j.tet.2019.04.069
https://doi.org/10.1016/j.tet.2019.04.069
Publikováno v:
ACS Chem Biol
Aberrations in the Hedgehog (Hh) signaling pathway are responsible for a broad range of human cancers, yet only a subset rely on the activity of the clinical target, Smoothened (Smo). Emerging cases of cancers that are insensitive to Smo-targeting dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45fc8545068d8e1ee4154538c007ba0f
https://resolver.caltech.edu/CaltechAUTHORS:20200602-071011767
https://resolver.caltech.edu/CaltechAUTHORS:20200602-071011767
Autor:
Daniel M. Spielman, Keshav Datta, Jae Mo Park, Shie Chau Liu, Andrew Castillo, Kelvin L. Billingsley, Marvin Wu, Heather Lough
Publikováno v:
Journal of the American Chemical Society. 139:6629-6634
Hyperpolarized 13C magnetic resonance spectroscopy (MRS) provides unprecedented opportunities to obtain clinical diagnostic information through in vivo monitoring of metabolic pathways. The continuing advancement of this field relies on the identific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ad86f3dd38388ba0624d84fac6ebca
https://doi.org/10.1021/jacs.7b00708
https://doi.org/10.1021/jacs.7b00708
Publikováno v:
Tetrahedron Letters. 66:152800
Prenyl or dimethylallyl groups are common structural motifs in natural products and small molecule therapeutics. In this report, we describe a palladium-catalyzed method for the cross-coupling of aryl and heteroaryl boronic acids with prenyl alcohol.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93b59427a1bb0de1a883bc7cb42ce3a3
https://doi.org/10.1016/j.tetlet.2020.152800
https://doi.org/10.1016/j.tetlet.2020.152800
Autor:
Ralph E. Hurd, Daniel M. Spielman, Juan Orduna, Richard Luong, Dirk Mayer, Adolf Pfefferbaum, Kelvin L. Billingsley, Sonal Josan, Liqing Yu, Jae Mo Park
Publikováno v:
NMR in Biomedicine. 28:1671-1677
To facilitate diagnosis and staging of liver disease, sensitive and non-invasive methods for the measurement of liver metabolism are needed. This study used hyperpolarized (13)C-pyruvate to assess metabolic parameters in a CCl4 model of liver damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::792890871a918957893dd6cd88205b05
https://doi.org/10.1002/nbm.3431
https://doi.org/10.1002/nbm.3431
Autor:
Kelvin L. Billingsley, Lynette Cegelski, Adam B. Lesser, Brian Loy, Daryl Staveness, Paul A. Wender
Publikováno v:
Journal of the American Chemical Society. 137:3678-3685
Protein kinase C (PKC) modulators are currently of great importance in preclinical and clinical studies directed at cancer, immunotherapy, HIV eradication, and Alzheimer’s disease. However, the bound conformation of PKC modulators in a membrane env
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c15b4f9ee10f78f58e6f8343b620eb0
https://doi.org/10.1021/jacs.5b00886
https://doi.org/10.1021/jacs.5b00886