Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kelvin Ka Lok Wu"'
Autor:
Kelvin Ka Lok Wu, KeKao Long, Huige Lin, Parco Ming Fai Siu, Ruby Lai Chong Hoo, Dewei Ye, Aimin Xu, Kenneth King Yip Cheng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Inflammasome regulation is not fully understood. Here the authors show that the early endosomal APPL1-Rab5 axis removes damaged mitochondria and then restricts the inflammasome response in macrophages, alleviating the inflammatory diseases.
Externí odkaz:
https://doaj.org/article/acd1f474dbe44e05886bd6aede2b54b2
Autor:
Kelvin Ka-lok Wu, Xiaofan Xu, Manyin Wu, Xiaomu Li, Moinul Hoque, Gloria Hoi Yee Li, Qizhou Lian, Kekao Long, Tongxi Zhou, Hailong Piao, Aimin Xu, Hannah Xiaoyan Hui, Kenneth King-yip Cheng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract M1 macrophages induce protective immunity against infection, but also contribute to metabolic and inflammatory diseases. Here we show that the E3 ubiquitin ligase, MDM2, promotes the glycolytic and inflammatory activities of M1 macrophage by
Externí odkaz:
https://doaj.org/article/a3cecd46ad844e0ca36f7a957405e747
Autor:
Li Zhu, Annie Wing-Tung Lee, Kelvin Ka-Lok Wu, Peng Gao, Kingsley King-Gee Tam, Rahim Rajwani, Galata Chala Chaburte, Timothy Ting-Leung Ng, Chloe Toi-Mei Chan, Hiu Yin Lao, Wing Cheong Yam, Richard Yi-Tsun Kao, Gilman Kit Hang Siu
Publikováno v:
Antibiotics, Vol 11, Iss 3, p 369 (2022)
The emergence of multidrug-resistant strains and hyper-virulent strains of Mycobacterium tuberculosis are big therapeutic challenges for tuberculosis (TB) control. Repurposing bioactive small-molecule compounds has recently become a new therapeutic a
Externí odkaz:
https://doaj.org/article/423ff6ac35df4bd99875f98dd272bdc1
Publikováno v:
Nature Communications
Autophagy
Autophagy
Although mitophagy is known to restrict NLRP3 inflammasome activation, the underlying regulatory mechanism remains poorly characterized. Here we describe a type of early endosome-dependent mitophagy that limits NLRP3 inflammasome activation. Deletion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27879fa1d57c469a4442b42fa6edb09b
https://pubmed.ncbi.nlm.nih.gov/34789781
https://pubmed.ncbi.nlm.nih.gov/34789781
Autor:
Palak Ahuja, Xinyi Bi, Chun Fai Ng, Margaret Chui Ling Tse, Miaojia Hang, Brian Pak Shing Pang, Elsie Chit Yu Iu, Wing Suen Chan, Xin Ci Ooi, Anqi Sun, Oana Herlea‐Pana, Zhixue Liu, Xiuying Yang, Baowei Jiao, Xin Ma, Kelvin Ka Lok Wu, Leo Tsz On Lee, Kenneth King Yip Cheng, Chi Wai Lee, Chi Bun Chan
Publikováno v:
Hepatology (Baltimore, Md.)REFERENCES.
Metabolism in the liver is dysregulated in obesity, contributing to various health problems including steatosis and insulin resistance. While the pathogenesis of lipid accumulation has been extensively studied, the protective mechanism against lipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ac345090baa0c2ccfed0cc6ce5f822
https://pubmed.ncbi.nlm.nih.gov/35363898
https://pubmed.ncbi.nlm.nih.gov/35363898
Autor:
Li Zhu, Annie Wing-Tung Lee, Kelvin Ka-Lok Wu, Peng Gao, Kingsley King-Gee Tam, Rahim Rajwani, Galata Chala Chaburte, Timothy Ting-Leung Ng, Chloe Toi-Mei Chan, Hiu Yin Lao, Wing Cheong Yam, Richard Yi-Tsun Kao, Gilman Kit Hang Siu
The emergence of multidrug-resistant strains and hyper-virulent strains of Mycobacterium tuberculosis are big therapeutic challenges for tuberculosis (TB) control. Repurposing bioactive small-molecule compounds has recently become a new therapeutic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c7d4ae83e435c922ad524100ed1d427
https://doi.org/10.1101/2021.11.05.467536
https://doi.org/10.1101/2021.11.05.467536
