Výsledky vyhledávání - "Kelvin Ka Lok Wu"

Akademický článek

MDM2 induces pro-inflammatory and glycolytic responses in M1 macrophages by integrating iNOS-nitric oxide and HIF-1α pathways in mice

Autor: Kelvin Ka-lok Wu, Xiaofan Xu, Manyin Wu, Xiaomu Li, Moinul Hoque, Gloria Hoi Yee Li, Qizhou Lian, Kekao Long, Tongxi Zhou, Hailong Piao, Aimin Xu, Hannah Xiaoyan Hui, Kenneth King-yip Cheng

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)

Abstract M1 macrophages induce protective immunity against infection, but also contribute to metabolic and inflammatory diseases. Here we show that the E3 ubiquitin ligase, MDM2, promotes the glycolytic and inflammatory activities of M1 macrophage by

Externí odkaz: https://doaj.org/article/a3cecd46ad844e0ca36f7a957405e747

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Akademický článek

The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages

Autor: Kelvin Ka Lok Wu, KeKao Long, Huige Lin, Parco Ming Fai Siu, Ruby Lai Chong Hoo, Dewei Ye, Aimin Xu, Kenneth King Yip Cheng

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Inflammasome regulation is not fully understood. Here the authors show that the early endosomal APPL1-Rab5 axis removes damaged mitochondria and then restricts the inflammasome response in macrophages, alleviating the inflammatory diseases.

Externí odkaz: https://doaj.org/article/acd1f474dbe44e05886bd6aede2b54b2

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Akademický článek

Screening Repurposed Antiviral Small Molecules as Antimycobacterial Compounds by a Lux-Based phoP Promoter-Reporter Platform

Autor: Li Zhu, Annie Wing-Tung Lee, Kelvin Ka-Lok Wu, Peng Gao, Kingsley King-Gee Tam, Rahim Rajwani, Galata Chala Chaburte, Timothy Ting-Leung Ng, Chloe Toi-Mei Chan, Hiu Yin Lao, Wing Cheong Yam, Richard Yi-Tsun Kao, Gilman Kit Hang Siu

Publikováno v: Antibiotics, Vol 11, Iss 3, p 369 (2022)

The emergence of multidrug-resistant strains and hyper-virulent strains of Mycobacterium tuberculosis are big therapeutic challenges for tuberculosis (TB) control. Repurposing bioactive small-molecule compounds has recently become a new therapeutic a

Externí odkaz: https://doaj.org/article/423ff6ac35df4bd99875f98dd272bdc1

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A new role of the early endosome in restricting NLRP3 inflammasome via mitophagy

Autor: Kelvin Ka Lok Wu, Kenneth King Yip Cheng

Publikováno v: Nature Communications
Autophagy

Although mitophagy is known to restrict NLRP3 inflammasome activation, the underlying regulatory mechanism remains poorly characterized. Here we describe a type of early endosome-dependent mitophagy that limits NLRP3 inflammasome activation. Deletion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27879fa1d57c469a4442b42fa6edb09b
https://pubmed.ncbi.nlm.nih.gov/34789781

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Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77-FGF21 pathway

Publikováno v: Hepatology (Baltimore, Md.)REFERENCES.

Metabolism in the liver is dysregulated in obesity, contributing to various health problems including steatosis and insulin resistance. While the pathogenesis of lipid accumulation has been extensively studied, the protective mechanism against lipid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ac345090baa0c2ccfed0cc6ce5f822
https://pubmed.ncbi.nlm.nih.gov/35363898

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