Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kelvin K H, Tong"'
Autor:
Matthew P. Sullivan, Muneebah Adams, Mie Riisom, Caitlin D. Herbert, Kelvin K. H. Tong, Jonathan W. Astin, Stephen M. F. Jamieson, Muhammad Hanif, David C. Goldstone, Christian G. Hartinger
Publikováno v:
Dalton Transactions. 52:1388-1392
Substitution of a labile Cl− for an NHC ligand in DNA-intercalating [Pt(terpyridine)]+ complexes improved the cytotoxicity and cellular accumulation, while in vivo studies indicated good tolerability in zebrafish.
Autor:
Kelvin K. H. Tong, Mie Riisom, Euphemia Leung, Muhammad Hanif, Tilo Söhnel, Stephen M. F. Jamieson, Christian G. Hartinger
Publikováno v:
Inorganic Chemistry. 61:17226-17241
The substitution of phenyl rings in established drugs with ferrocenyl moieties has been reported to yield compounds with improved biological activity and alternative modes of action, often involving the formation of reactive oxygen species (ROS). Tra
Autor:
Jahanzaib Arshad, Kelvin K. H. Tong, Sanam Movassaghi, Tilo Söhnel, Stephen M. F. Jamieson, Muhammad Hanif, Christian G. Hartinger
Publikováno v:
Molecules, Vol 26, Iss 4, p 833 (2021)
RuII(cym)Cl (cym = η6-p-cymene) complexes of pyridinecarbothioamides have shown potential for development as orally active anticancer metallodrugs, underlined by their high selectivity towards plectin as the molecular target. In order to investigate
Externí odkaz:
https://doaj.org/article/0c29b966a1e74fa9bb1d5c7c6222e631
Autor:
Christopher Wittmann, Anastasiia S. Sivchenko, Felix Bacher, Kelvin K. H. Tong, Navjot Guru, Thomas Wilson, Junior Gonzales, Hartmut Rauch, Susanne Kossatz, Thomas Reiner, Maria V. Babak, Vladimir B. Arion
Publikováno v:
Inorganic Chemistry
Indolo[2,3-d]benzazepines (indololatonduines) are rarely discussed in the literature. In this project, we prepared a series of novel indololatonduine derivatives and their RuII and OsII complexes and investigated their microtubule-targeting propertie
Autor:
Kelvin K. H. Tong, Muhammad Hanif, James H. Lovett, Katja Hummitzsch, Hugh H. Harris, Tilo Söhnel, Stephen M. F. Jamieson, Christian G. Hartinger
Publikováno v:
Molecules, Vol 25, Iss 16, p 3661 (2020)
Thiones have been investigated as ligands in metal complexes with catalytic and biological activity. We report the synthesis, characterization, and biological evaluation of a series of MII/III complexes of the general formulae [MII(cym)(L)Cl]X (cym =
Externí odkaz:
https://doaj.org/article/166377e9d24f47daa7cd997320496ee8
Autor:
Matthew P. Sullivan, Ena Yano, Betty Y. T. Lee, David C. Goldstone, Stephen M. F. Jamieson, Tilo Soehnel, Muhammad Hanif, Christian G. Hartinger, Kelvin K. H. Tong, Tomoyo Kawakubo-Yasukochi
Publikováno v:
Inorganic Chemistry. 60:14636-14644
N-Heterocyclic carbene (NHC) ligands are widely investigated in medicinal inorganic chemistry. Here, we report the preparation and characterization of a series of half-sandwich [M(L)(NHC)Cl2] (M = Ru, Os, Rh, Ir; L = cym/Cp*) complexes with a N-flank
Autor:
Christian G. Hartinger, Sanam Movassaghi, Kelvin K. H. Tong, James H. Lovett, Suresh K. Bhargava, Katja Hummitzsch, Hugh H. Harris, Stephen M. F. Jamieson, Muhammad Hanif, Tilo Söhnel, Matthew P. Sullivan
Publikováno v:
ChemMedChem. 16:3017-3026
We report investigations on the anticancer activity of organometallic [MII/III (η6 -p-cymene/η5 -pentamethylcyclopentadienyl)] (M=Ru, Os, Rh, and Ir) complexes of N-heterocyclic carbenes (NHCs) substituted with a triazolyl moiety. Depending on the
Autor:
Betty Y. T. Lee, Muhammad Hanif, Christian G. Hartinger, Kelvin K. H. Tong, Tilo Söhnel, Andrew D. Phillips
Publikováno v:
Inorganic Chemistry. 60:8734-8741
Investigations on incorporating an N-flanking anthracenyl moiety to [Rh(Cp*)(NHC)Cl2] complexes surprisingly led to the formation of an intramolecular C-C bond between the Cp* and anthracenyl moieties, with additional auxiliary interactions between t
Autor:
Christian G. Hartinger, Euphemia Leung, Mie Riisom, Kelvin K. H. Tong, Muhammad Hanif, Ena Yano
Publikováno v:
Analytical Methods. 13:1463-1469
Ruthenium-based complexes have attracted attention as promising anticancer candidates due to their lower general toxicity than the widely used platinum drugs. The complex [RuII(η6-p-cymene)(8-oxyquinolinato)Cl] 1 has shown significant cytotoxic acti
Autor:
Matthew P. Sullivan, David C. Goldstone, Muhammad Hanif, Hugh H. Harris, Katja Hummitzsch, Jake W Andersen, Dianna Truong, Kelvin K. H. Tong, James H. Lovett, Tilo Söhnel, Christian G. Hartinger, Ingo Ott, Nils Metzler-Nolte, Tasha R. Steel, Stephen M. F. Jamieson, Andre Prause, Claire M. Weekley
Publikováno v:
Inorganic Chemistry. 59:3281-3289
Metal complexes provide a versatile platform to develop novel anticancer pharmacophores, and they form stable compounds with N-heterocyclic carbene (NHC) ligands, some of which have been shown to inhibit the cancer-related selenoenzyme thioredoxin re