Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kelvin H. M. Kwok"'
Autor:
Lai Yee Cheong, Baile Wang, Qin Wang, Leigang Jin, Kelvin H. M. Kwok, Xiaoping Wu, Lingling Shu, Huige Lin, Sookja Kim Chung, Kenneth K. Y. Cheng, Ruby L. C. Hoo, Aimin Xu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Beiging and thermogenesis in white adipose tissue (WAT) is an important adaptive response to cold exposure, but how the brain senses cold and subsequently induces beiging remains unclear. Here, the authors show that sympathetic nerves stimulate lymph
Externí odkaz:
https://doaj.org/article/855172dea7104e12b8e6ff973eaba45e
Autor:
Alastair G. Kerr, Zuoneng Wang, Na Wang, Kelvin H. M. Kwok, Jutta Jalkanen, Alison Ludzki, Simon Lecoutre, Dominique Langin, Martin O. Bergo, Ingrid Dahlman, Carsten Mim, Peter Arner, Hui Gao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Adipocyte-expressed long non-coding RNAs (lncRNAs) have been shown to regulate the transcription of genes involved in lipid metabolism. Here the authors describe a human adipocyte-specific lncRNA, ADIPINT, which regulates lipid metabolism in white ad
Externí odkaz:
https://doaj.org/article/733d5e4bb73b45358b2a2883dd271e1f
Autor:
Salwan Maqdasy, Bertrand Barres, Gaelle Salaun, Marie Batisse-Lignier, Celine Pebrel-Richard, Kelvin H. M. Kwok, André Labbé, Philippe Touraine, Florence Brugnon, Igor Tauveron
Publikováno v:
Basic and Clinical Andrology, Vol 30, Iss 1, Pp 1-7 (2020)
Résumé Introduction Une puberté précoce centrale idiopathique (PPCI) est. extrêmement rare chez le garçon. Sa prévalence chez les garçons présentant un syndrome de Klinefelter (SK) est méconnue. Nous décrivons un cas rare de PPCI chez un g
Externí odkaz:
https://doaj.org/article/ced710e0b89549f6a053b46b3bbb2ec0
Autor:
Kelvin H. M. Kwok, Karen S. L. Lam
Publikováno v:
Endocrinology and Metabolism, Vol 32, Iss 2, Pp 145-151 (2017)
Fibroblast growth factor 21 (FGF21) is an atypical member of the FGF family. Acting in an endocrine fashion, it increases glucose uptake, modulates lipid metabolism, and sensitizes insulin response in metabolically active organs, including the liver
Externí odkaz:
https://doaj.org/article/ede7eeed0ac74c329dcacb6e1120c866
Autor:
Alastair G. Kerr, Zuoneng Wang, Na Wang, Kelvin H. M. Kwok, Jutta Jalkanen, Alison Ludzki, Simon Lecoutre, Dominique Langin, Martin O. Bergo, Ingrid Dahlman, Carsten Mim, Peter Arner, Hui Gao
Publikováno v:
Nature communications. 13(1)
The pleiotropic function of long noncoding RNAs is well recognized, but their direct role in governing metabolic homeostasis is less understood. Here, we describe a human adipocyte-specific lncRNA, ADIPINT, that regulates pyruvate carboxylase, a pivo
Autor:
Karen S.L. Lam, Ian Y. H. Wong, Carol H.Y. Fong, Pak C. Sham, Chloe Y Y Cheung, Kenneth K. W. Li, Michele M A Yuen, Wing Sun Chow, Kelvin H M Kwok, Aimin Xu, RA Gangwani, Yu Cho Woo, Chi Ho Lee, Rachel L.C. Wong, Kelvin K. K. Ng, David Wong
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Glycemic control has been recognized as an important modifiable risk factor for diabetic retinopathy (DR). Whether hemoglobin A1c (HbA1c), as an indicator of glycemic control, could modify the genetic susceptibility to severe DR remains to be
Autor:
Chloe Y Y Cheung, Michele M A Yuen, Wing Sun Chow, Karen S.L. Lam, Aimin Xu, Kelvin H M Kwok, Kathryn C.B. Tan, YC Woo, Kelvin K. K. Ng, Tai Hing Lam, Chi Ho Lee, Hung-Fat Tse, Pak C. Sham, Jo-Jo Hai, Clara S. Tang, Carol H.Y. Fong, Ka-Wing Au
Publikováno v:
Diabetes. 68:198-206
Elevated circulating levels of pigment epithelium-derived factor (PEDF) have been reported in patients with type 2 diabetes (T2D) and its associated microvascular complications. This study aimed to 1) identify the genetic determinants influencing cir
Autor:
Stacey S. Cherny, Yu Cho Woo, Bernard M.Y. Cheung, Carol H.Y. Fong, Lin Xu, Ka-Wing Au, Kelvin H M Kwok, Kathryn C.B. Tan, Karen S.L. Lam, Tai Hing Lam, Wing Sun Chow, Aimin Xu, Chi Ho Lee, Clara S. Tang, Pak C. Sham, Chloe Y Y Cheung, Michele M A Yuen, Jo-Jo Hai, Hung-Fat Tse
Publikováno v:
Diabetes. 66:1723-1728
Fibroblast growth factor 21 (FGF21) is increasingly recognized as an important metabolic regulator of glucose homeostasis. Here, we conducted an exome-chip association analysis by genotyping 5,169 Chinese individuals from a community-based cohort and
Publikováno v:
Clinical Science. 130:2087-2100
Both atherosclerosis and obesity, an independent atherosclerotic risk factor, are associated with enhanced systemic inflammation. Obesity is also characterized by increased adipose tissue inflammation. However, the molecular mechanism underlying the
Autor:
Chloe Y Y, Cheung, Clara S, Tang, Aimin, Xu, Chi-Ho, Lee, Ka-Wing, Au, Lin, Xu, Carol H Y, Fong, Kelvin H M, Kwok, Wing-Sun, Chow, Yu-Cho, Woo, Michele M A, Yuen, Stacey S, Cherny, JoJo, Hai, Bernard M Y, Cheung, Kathryn C B, Tan, Tai-Hing, Lam, Hung-Fat, Tse, Pak-Chung, Sham, Karen S L, Lam
Publikováno v:
Diabetes. 66(6)
Fibroblast growth factor 21 (FGF21) is increasingly recognized as an important metabolic regulator of glucose homeostasis. Here, we conducted an exome-chip association analysis by genotyping 5,169 Chinese individuals from a community-based cohort and