Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kelvin D. MacDonald"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Cystic fibrosis is a life-threatening disease that is caused by mutations in CFTR, a gene which encodes an ion channel that supports proper function of several epithelial tissues, most critically the lung. Without CFTR, airway barrier mechanisms are
Externí odkaz:
https://doaj.org/article/2eb8cca551f34e00a315f7dd26e0fd0c
Publikováno v:
Biol Reprod
The cystic fibrosis transmembrane conductance regulator (CFTR) is an apical membrane chloride/bicarbonate ion channel in epithelial cells. Mutations in CFTR cause cystic fibrosis, a disease characterized by thickened mucus secretions and is associate
Autor:
Jeonghwan Kim, Antony Jozic, Yuxin Lin, Yulia Eygeris, Elissa Bloom, Xiaochen Tan, Christopher Acosta, Kelvin D. MacDonald, Kevin D. Welsher, Gaurav Sahay
Publikováno v:
ACS nano. 16(9)
Despite lipid nanoparticles' (LNPs) success in the effective and safe delivery of mRNA vaccines, an inhalation-based mRNA therapy for lung diseases remains challenging. LNPs tend to disintegrate due to shear stress during aerosolization, leading to i
Publikováno v:
Pediatric Pulmonology. 56:891-900
An acute pulmonary exacerbation (APE) in Cystic Fibrosis (CF) is characterized by increased pulmonary symptoms attributed to bacterial colonization, neutrophil recruitment and inflammation. Antimicrobials, airway clearance and nutrition are the mains
Autor:
Cindy T, McEvoy, Lyndsey E, Shorey-Kendrick, Kristin, Milner, Julia, Harris, Brittany, Vuylsteke, Michelle, Cunningham, Christina, Tiller, Jaclene, Stewart, Diane, Schilling, Julie, Brownsberger, Hope, Titus, Kelvin D, MacDonald, David, Gonzales, Annette, Vu, Byung S, Park, Eliot R, Spindel, Cynthia D, Morris, Robert S, Tepper
Publikováno v:
JAMA Pediatr
ImportanceVitamin C supplementation (500 mg/d) for pregnant smokers has been reported to increase offspring airway function as measured by forced expiratory flow (FEF) through age 12 months; however, its effects on airway function at age 5 years rema
Autor:
Jeonghwan Kim, Kelvin D. MacDonald, Yulia Eygeris, Anindit Mukherjee, Gaurav Sahay, Michael I. Henderson
Publikováno v:
Science Advances
A nanoparticle delivered ENaC-inhibitory mRNA for the treatment of cystic fibrosis.
Cystic fibrosis (CF) results from mutations in the chloride-conducting CF transmembrane conductance regulator (CFTR) gene. Airway dehydration and impaired mucoci
Cystic fibrosis (CF) results from mutations in the chloride-conducting CF transmembrane conductance regulator (CFTR) gene. Airway dehydration and impaired mucoci
Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis
Autor:
Conroy Sun, Ema Robinson, Siddharth Patel, Gaurav Sahay, Madison McKinney, Kelvin D. MacDonald, Kai Slaughter
Publikováno v:
Molecular Therapy. 26:2034-2046
The promise of gene therapy for the treatment of cystic fibrosis has yet to be fully clinically realized despite years of effort toward correcting the underlying genetic defect in the cystic fibrosis transmembrane conductance regulator (CFTR). mRNA t
Autor:
Ashley Scherman, Kristine L. Funk, Cindy T. McEvoy, Jodi Lapidus, Kelvin D. MacDonald, Victor J. Stevens, Sheila Markwardt, Kimberly K Vesco
Publikováno v:
Pediatric Allergy, Immunology, and Pulmonology. 31:84-90
Prepregnancy overweight and obesity have been linked to early childhood wheezing and asthma, but the presence and strength of such associations are mixed and the underlying biological mechanisms re...
Autor:
Dmitry Dukhovny, Leah Yieh, Cindy T. McEvoy, Aaron B. Caughey, Kelvin D. MacDonald, Scott W. Hoffman
Publikováno v:
Journal of Perinatology. 38:820-827
To determine the implications of supplemental vitamin C for pregnant tobacco smokers and its effects on the prevalence of pediatric asthma, asthma-related mortality, and associated costs. A decision-analytic model built via TreeAge compared the outco
Autor:
Eliot R. Spindel, Ryan Lam, Byung Park, Kelvin D. MacDonald, Michael H. Davies, Robert S. Tepper, Cindy T. McEvoy, Kelli Lund
Publikováno v:
Pediatr Pulmonol