Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Kelsie L, Thu"'
Autor:
Ryunosuke Hoshi, Kristyna A. Gorospe, Hagar I. Labouta, Taha Azad, Warren L. Lee, Kelsie L. Thu
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1181 (2024)
The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) immune checkpoint constitutes an inhibitory pathway best known for its regulation of cluster of differentiation 8 (CD8)+ T cell-mediated immune responses. Engagement of PD-L1 with PD-1 exp
Externí odkaz:
https://doaj.org/article/f13191e2d6204ae8a28fa2684818ea98
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2516 (2022)
Targeted drug and gene delivery using ultrasound and microbubbles (USMB) has the potential to treat several diseases. In vitro investigation of USMB-mediated delivery is of prime importance prior to in vivo studies because it is cost-efficient and al
Externí odkaz:
https://doaj.org/article/1fff6a5f3191413f9b0ff080c4845b61
Autor:
Cerise Yuen‐Ki Chan, Vincent Wai‐Hin Yuen, David Kung‐Chun Chiu, Chi‐Ching Goh, Kelsie L. Thu, David W. Cescon, Isabel Soria‐Bretones, Cheuk‐Ting Law, Jacinth Wing‐Sum Cheu, Derek Lee, Aki Pui‐Wah Tse, Kel Vin Tan, Misty Shuo Zhang, Bowie Po‐Yee Wong, Chun‐Ming Wong, Pek‐Lan Khong, Irene Oi‐Lin Ng, Mark R. Bray, Tak Wah Mak, Thomas Chung‐Cheung Yau, Carmen Chak‐Lui Wong
Publikováno v:
Hepatology. 77:729-744
Prognosis of HCC remains poor due to lack of effective therapies. Immune checkpoint inhibitors (ICIs) have delayed response and are only effective in a subset of patients. Treatments that could effectively shrink the tumors within a short period of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ebe6f37bb9876de85a5a9fc93555119
https://doi.org/10.1002/hep.32461
https://doi.org/10.1002/hep.32461
Autor:
Zhaleh Safikhani, Petr Smirnov, Kelsie L. Thu, Jennifer Silvester, Nehme El-Hachem, Rene Quevedo, Mathieu Lupien, Tak W. Mak, David Cescon, Benjamin Haibe-Kains
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Altered mRNA splicing features in many cancers, but it has not been linked to drug response. Here, with their meta-analytic framework, the authors analyse pharmacogenomic data to identify isoform-based biomarkers predictive of in vitro drug response,
Externí odkaz:
https://doaj.org/article/cf7eac9f211140b5ac75f6d34ebece89
Autor:
Ethan Dmitrovsky, Xi Liu, Tak W. Mak, Ignacio I. Wistuba, Jaime Rodriguez-Canales, David W Cescon, Kelsie L. Thu, Jennifer Silvester, Luisa M. Solis, Barbara Mino, Carmen Behrens, Wei Lu, Pamela Villalobos, Jonathan M. Kurie, Lisa Maria Mustachio, Jason Roszik, Yulong Chen, Masanori Kawakami, Zibo Chen, Lin Zheng
The spindle assembly checkpoint maintains genomic integrity. A key component is tyrosine threonine kinase (TTK, also known as Mps1). TTK antagonism is hypothesized to cause genomic instability and cell death. Interrogating The Cancer Genome Atlas rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa57f94649535dc1900eeb0fa9c6cbf
https://doi.org/10.1158/1535-7163.c.6537774.v1
https://doi.org/10.1158/1535-7163.c.6537774.v1
Autor:
Ethan Dmitrovsky, Xi Liu, Tak W. Mak, Ignacio I. Wistuba, Jaime Rodriguez-Canales, David W Cescon, Kelsie L. Thu, Jennifer Silvester, Luisa M. Solis, Barbara Mino, Carmen Behrens, Wei Lu, Pamela Villalobos, Jonathan M. Kurie, Lisa Maria Mustachio, Jason Roszik, Yulong Chen, Masanori Kawakami, Zibo Chen, Lin Zheng
Figure S1: The structure of CFI-402257. Figure S2: TTK mRNA expression profiles in lung cancer cases with different smoking patterns, as shown in panel A. In this left panel N means no smoking history while Y indicates the presence of a smoking histo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8022f80f2f05d71c7880d9bd62d6aa72
https://doi.org/10.1158/1535-7163.22504551.v1
https://doi.org/10.1158/1535-7163.22504551.v1
Autor:
David G. Beer, Wan L. Lam, Raj Chari, Larissa A. Pikor, Lin Lin, Kelsie L. Thu, William W. Lockwood
Purpose: Esophageal adenocarcinoma (EAC) is a lethal malignancy that can develop from the premalignant condition, Barrett's esophagus (BE). Currently, there are no validated simple methods to predict which patients will progress to EAC. A better unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e7ffca8e320f4870026e4f3e7117f8
https://doi.org/10.1158/1078-0432.c.6520350.v1
https://doi.org/10.1158/1078-0432.c.6520350.v1