Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kelsi O. West"'
Autor:
Allison R Wagner, Chi G Weindel, Kelsi O West, Haley M Scott, Robert O Watson, Kristin L Patrick
Publikováno v:
eLife, Vol 11 (2022)
To mount a protective response to infection while preventing hyperinflammation, gene expression in innate immune cells must be tightly regulated. Despite the importance of pre-mRNA splicing in shaping the proteome, its role in balancing immune outcom
Externí odkaz:
https://doaj.org/article/6d3c3ed1193744ab8bd751412b25e522
Autor:
Allison R. Wagner, Haley M. Scott, Kelsi O. West, Krystal J. Vail, Timothy C. Fitzsimons, Aja K. Coleman, Kaitlyn E. Carter, Robert O. Watson, Kristin L. Patrick
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Pathogen sensing via pattern recognition receptors triggers massive reprogramming of macrophage gene expression. While the signaling cascades and transcription factors that activate these responses are well-known, the role of post-transcriptional RNA
Externí odkaz:
https://doaj.org/article/adf17969b3064de09dc3a7b71d0e7eb2
Autor:
Chi G Weindel, Samantha L Bell, Krystal J Vail, Kelsi O West, Kristin L Patrick, Robert O Watson
Publikováno v:
eLife, Vol 9 (2020)
The Parkinson’s disease (PD)-associated gene leucine-rich repeat kinase 2 (LRRK2) has been studied extensively in the brain. However, several studies have established that mutations in LRRK2 confer susceptibility to mycobacterial infection, suggest
Externí odkaz:
https://doaj.org/article/4caa4bf04ba84861995ba7c4bd7c84fd
Autor:
Kelsi O. West, Haley M. Scott, Sylvia Torres-Odio, A. Phillip West, Kristin L. Patrick, Robert O. Watson
Publikováno v:
Cell Reports, Vol 29, Iss 6, Pp 1594-1609.e5 (2019)
Summary: While transcriptional control of innate immune gene expression is well characterized, almost nothing is known about how pre-mRNA splicing decisions influence, or are influenced by, macrophage activation. Here, we demonstrate that the splicin
Externí odkaz:
https://doaj.org/article/d1e1fb54deb54b45b05c395f599674fb
Autor:
Shouvonik Sengupta, Kelsi O West, Shridhar Sanghvi, Mireia Guerau-de-Arellano, Georgios Laliotis, Kristin L. Patrick, Harpreet Singh, Kristen W. Lynch, Laura M. Agosto, Philip N. Tsichlis
Publikováno v:
ImmunoHorizons. 5:884-897
Protein arginine methyltransferase (PRMT) 5 is the type 2 methyltransferase catalyzing symmetric dimethylation of arginine. PRMT5 inhibition or deletion in CD4 Th cells reduces TCR engagement-induced IL-2 production and Th cell expansion and confers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef7b688f6fca20e32f9708a7e09e32c3
https://doi.org/10.4049/immunohorizons.2100076
https://doi.org/10.4049/immunohorizons.2100076
Autor:
Tao Jing, Jeffery S. Cox, Kelsi O West, Pingwei Li, Kristin L. Patrick, Robert O. Watson, Allison R Wagner, A. Phillip West, Sylvia Torres-Odio, Samantha L. Bell, Caitlyn T. Hoffpauir
Publikováno v:
J Immunol
Tripartite motif-containing proteins (TRIMs) play a variety of recently described roles in innate immunity. Although many TRIMs regulate type I IFN expression following cytosolic nucleic acid sensing of viruses, their contribution to innate immune si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556cf515744928016485d01393233fef
https://doi.org/10.4049/jimmunol.1901511
https://doi.org/10.4049/jimmunol.1901511
Autor:
Harpreet Singh, Kristin L. Patrick, Shouvonik Sengupta, Philip N. Tsichlis, Kelsi O West, Shridhar Sanghvi, Mireia Guerau-de-Arellano, Georgios Laliotis, Laura M. Agosto, Kristen W. Lynch
Protein Arginine Methyltransferase (PRMT) 5 is the major type 2 methyltransferase catalyzing symmetric dimethylation (SDM) of arginine. PRMT5 inhibition or deletion in CD4 Th cells reduces TcR engagement-induced IL-2 production and Th cell expansion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1a3dc63c608442665ce2092ec7eca41
https://doi.org/10.1101/2021.08.24.457384
https://doi.org/10.1101/2021.08.24.457384
Autor:
Kristin L. Patrick, Allison R Wagner, Robert O. Watson, Krystal J Vail, Haley M. Scott, Kelsi O West, Kaitlin Carter
Pathogen sensing via pattern recognition receptors triggers massive reprogramming of macro-phage gene expression. While the signaling cascades and transcription factors that activate these responses are well-known, the role of post-transcriptional RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cca9f00999165dd60999801fda84f470
https://doi.org/10.1101/2020.12.06.413690
https://doi.org/10.1101/2020.12.06.413690