Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kelsi O West"'
Autor:
Allison R Wagner, Chi G Weindel, Kelsi O West, Haley M Scott, Robert O Watson, Kristin L Patrick
Publikováno v:
eLife, Vol 11 (2022)
To mount a protective response to infection while preventing hyperinflammation, gene expression in innate immune cells must be tightly regulated. Despite the importance of pre-mRNA splicing in shaping the proteome, its role in balancing immune outcom
Externí odkaz:
https://doaj.org/article/6d3c3ed1193744ab8bd751412b25e522
Autor:
Chi G Weindel, Samantha L Bell, Krystal J Vail, Kelsi O West, Kristin L Patrick, Robert O Watson
Publikováno v:
eLife, Vol 9 (2020)
The Parkinson’s disease (PD)-associated gene leucine-rich repeat kinase 2 (LRRK2) has been studied extensively in the brain. However, several studies have established that mutations in LRRK2 confer susceptibility to mycobacterial infection, suggest
Externí odkaz:
https://doaj.org/article/4caa4bf04ba84861995ba7c4bd7c84fd
Autor:
Kelsi O. West, Haley M. Scott, Sylvia Torres-Odio, A. Phillip West, Kristin L. Patrick, Robert O. Watson
Publikováno v:
Cell Reports, Vol 29, Iss 6, Pp 1594-1609.e5 (2019)
Summary: While transcriptional control of innate immune gene expression is well characterized, almost nothing is known about how pre-mRNA splicing decisions influence, or are influenced by, macrophage activation. Here, we demonstrate that the splicin
Externí odkaz:
https://doaj.org/article/d1e1fb54deb54b45b05c395f599674fb
Autor:
Shouvonik Sengupta, Kelsi O West, Shridhar Sanghvi, Mireia Guerau-de-Arellano, Georgios Laliotis, Kristin L. Patrick, Harpreet Singh, Kristen W. Lynch, Laura M. Agosto, Philip N. Tsichlis
Publikováno v:
ImmunoHorizons. 5:884-897
Protein arginine methyltransferase (PRMT) 5 is the type 2 methyltransferase catalyzing symmetric dimethylation of arginine. PRMT5 inhibition or deletion in CD4 Th cells reduces TCR engagement-induced IL-2 production and Th cell expansion and confers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef7b688f6fca20e32f9708a7e09e32c3
https://doi.org/10.4049/immunohorizons.2100076
https://doi.org/10.4049/immunohorizons.2100076
Autor:
Tao Jing, Jeffery S. Cox, Kelsi O West, Pingwei Li, Kristin L. Patrick, Robert O. Watson, Allison R Wagner, A. Phillip West, Sylvia Torres-Odio, Samantha L. Bell, Caitlyn T. Hoffpauir
Publikováno v:
J Immunol
Tripartite motif-containing proteins (TRIMs) play a variety of recently described roles in innate immunity. Although many TRIMs regulate type I IFN expression following cytosolic nucleic acid sensing of viruses, their contribution to innate immune si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556cf515744928016485d01393233fef
https://doi.org/10.4049/jimmunol.1901511
https://doi.org/10.4049/jimmunol.1901511
Autor:
Harpreet Singh, Kristin L. Patrick, Shouvonik Sengupta, Philip N. Tsichlis, Kelsi O West, Shridhar Sanghvi, Mireia Guerau-de-Arellano, Georgios Laliotis, Laura M. Agosto, Kristen W. Lynch
Protein Arginine Methyltransferase (PRMT) 5 is the major type 2 methyltransferase catalyzing symmetric dimethylation (SDM) of arginine. PRMT5 inhibition or deletion in CD4 Th cells reduces TcR engagement-induced IL-2 production and Th cell expansion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1a3dc63c608442665ce2092ec7eca41
https://doi.org/10.1101/2021.08.24.457384
https://doi.org/10.1101/2021.08.24.457384
Autor:
Kristin L. Patrick, Allison R Wagner, Robert O. Watson, Krystal J Vail, Haley M. Scott, Kelsi O West, Kaitlin Carter
Pathogen sensing via pattern recognition receptors triggers massive reprogramming of macro-phage gene expression. While the signaling cascades and transcription factors that activate these responses are well-known, the role of post-transcriptional RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cca9f00999165dd60999801fda84f470
https://doi.org/10.1101/2020.12.06.413690
https://doi.org/10.1101/2020.12.06.413690