Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kelsey Sivick Gauthier"'
Autor:
Matthew Walters, Stephen Young, Ada Chen, Kelsey Sivick Gauthier, Dana Piovesan, Soonweng Cho, Xiaoning Zhao, Nigel Walker, Alejandra Lopez, Patrick Schweickert, Ferdie Soriano, Hema Singh
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/610b3ca19ff24326aa41a2bee6dba752
Autor:
Matthew Walters, Stephen Young, Ada Chen, Akshata Udyavar, Kelsey Sivick Gauthier, Dana Piovesan, Kenneth Lawson, Soonweng Cho, Jean Chan, Jennie Au, Cesar Meleza, Xiaoning Zhao, Anh Tran, Samuel Drew, Balint Gal, Brandon Rosen, Manmohan Leleti, Elaine Ginn, Lixia Jin, Jay Powers
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/1e683cc12e9e427ab6682463ac6f0bb9
Autor:
Hema Singh, Kelsey Sivick Gauthier, Ferdie Soriano, Soonweng Cho, Xiaoning Zhao, Nigel Walker, Alejandra Lopez, Patrick Schweickert, Matthew Walters, Ada Chen, Dana Piovesan, Stephen P. Young
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundTIGIT (T-cell immunoreceptor with Ig and ITIM domains) is an inhibitory receptor expressed on natural killer (NK) cells, CD8< sup >+ T cells, CD4< sup >+ T cells and regulatory T cells (T < sub >regs). On the surface of these cells, TIGIT c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93e342781fb5dbd3454dbdf14aef765
https://doaj.org/article/610b3ca19ff24326aa41a2bee6dba752
https://doaj.org/article/610b3ca19ff24326aa41a2bee6dba752
Autor:
Jean Chan, Lixia Jin, Kelsey Sivick Gauthier, Stephen W Young, Matthew J. Walters, Balint Gal, Anh Tran, Kenneth V. Lawson, Elaine Ginn, Manmohan Reddy Leleti, Jennie Au, Soonweng Cho, Dana Piovesan, Xiaoning Zhao, Akshata Udyavar, Jay P. Powers, Ada Chen, Cesar Meleza, Brandon Reid Rosen, Samuel L Drew
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background The microenvironment of solid tumors is hypoxic and requires induction of genes associated with metabolism, growth, proliferation, and angiogenesis for cancer cells to survive and metastasize. The master transcriptional regulators of hypox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce023df8e6af859a49a662f82516a0b5
https://doi.org/10.1136/jitc-2020-sitc2020.0583
https://doi.org/10.1136/jitc-2020-sitc2020.0583
Autor:
Lora Picton, Li Zhang, Cristina Blaj, Gail Snyder, Sarah M. McWhirter, Christopher J. Nicolai, David H. Raulet, Kelsey Sivick Gauthier, Chudi Ndubaku, Natalie K. Wolf, K. Christopher Garcia
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A614-A614
BackgroundMost current cancer immunotherapies are based on mobilizing CD8 T cell responses. However, many types of tumors evade CD8 T cell recognition by displaying few or no antigens, or losing expression of MHC I. These considerations underlie the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f16b8f54c04ca9725e50d12724bf5e3a
https://doi.org/10.1136/jitc-2021-sitc2021.584
https://doi.org/10.1136/jitc-2021-sitc2021.584
Autor:
Stephen W. Young, Guillaume Mata, Joel W. Beatty, Matthew J. Walters, Kelsey Sivick Gauthier, Jeremy Fournier, Jennifer Au, Jay P. Powers, Dana Piovesan, Artur K. Mailyan, Kenneth V. Lawson, Manmohan Reddy Leleti, Elaine Ginn, Jarek Kalisiak, Xuelei Yan, Balint Gal, Zhang Wang, Lixia Jin, Samuel L Drew, Cesar Meleza
Publikováno v:
Cancer Research. 81:1206-1206
A hypoxic environment is a common characteristic of solid tumors. Cancer cells adapt to hypoxia and become more aggressive by up-regulation of genes associated with metabolism, growth, proliferation, angiogenesis, and erythropoiesis. Hypoxia-inducibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d5fa52383b1811c1aeb7706770bc35e
https://doi.org/10.1158/1538-7445.am2021-1206
https://doi.org/10.1158/1538-7445.am2021-1206
Autor:
Meredith L. Leong, Weiwen Deng, Chudi Ndubaku, Sarah M. McWhirter, Lianxing Zheng, Ken Metchette, Kelsey Sivick Gauthier, Jeffery M. McKenna, Laura Hix Glickman, Charles Y. Cho, Tamara Schroeder, Anthony L. Desbien, Natalie H. Surh, Andrea van Elsas, Bender Steven Lee, Yan Feng, Leticia Corrales, Justin Leong, Brian Francica, Gabrielle L. Reiner
Publikováno v:
Cancer Immunology Research. 8:PR09-PR09
Stimulator of interferon genes (STING) is a critical component of an innate immune pathway that activates robust antiviral and antitumor responses in mouse models. Activation of the STING pathway by intratumoral (IT) injection of synthetic cyclic din
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9df6bffd8ad77a817a63a66f6b141683
https://doi.org/10.1158/2326-6074.tumimm18-pr09
https://doi.org/10.1158/2326-6074.tumimm18-pr09
Autor:
Xiaoning Zhao, Manmohan Reddy Leleti, Jay P. Powers, Steve Young, Tim Park, Samuel L Drew, Elaine Ginn, Anh Tran, Dana Piovesan, Kelsey Sivick Gauthier, Nikki Kimura, Cesar Meleza, Lixia Jin, Matthew J. Walters, Kenneth V. Lawson, Ada Chen
Publikováno v:
Molecular Cancer Therapeutics. 18:C050-C050
The microenvironment of solid tumors is known to be hypoxic and requires induction of genes associated with metabolism, growth, proliferation, and angiogenesis for tumor cells to survive and metastasize. The master transcriptional regulator of hypoxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f91bc456411050792f8dbc52338fbae
https://doi.org/10.1158/1535-7163.targ-19-c050
https://doi.org/10.1158/1535-7163.targ-19-c050
Autor:
Weiwen Deng, Jeffery M. McKenna, George E. Katibah, Andrea van Elsas, Ken Metchette, Bender Steven Lee, Thomas W. Dubensky, Thomas E. Hudson, Uyen T. Vu, Kelsey Sivick Gauthier, Meredith L. Leong, Sarah M. McWhirter, Leticia Corrales, Laura Hix Glickman, Gabrielle L. Reiner, Brian Francica, Justin Leong, David B. Kanne, Anthony L. Desbien, Chudi Ndubaku, Natalie H. Surh
Publikováno v:
Cancer Research. 78:631-631
Activation of the STING pathway by intratumoral (IT) injection of synthetic cyclic dinucleotides (CDNs) induces stable tumor regression in preclinical models, yet the underlying immune correlates are not fully understood. ADU-S100, a CDN under clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9379be812259548e9f3f0235608429ef
https://doi.org/10.1158/1538-7445.am2018-631
https://doi.org/10.1158/1538-7445.am2018-631
Autor:
Meredith L. Leong, George E. Katibah, Lianxing Zheng, Yan Feng, Leticia Corrales, Tony Desbien, Justin Leong, AnneMarie Culazzo Pferdekamper, John A. Tallarico, Bender Steven Lee, Sarah M. McWhirter, Ed Lemmens, Leonard Sung, Laura Hix Glickman, Chudi Ndubaku, Jeffery M. McKenna, Jie Li, Charles Y. Cho, Kelsey Sivick Gauthier, Shailaja Kasibhatla, David B. Kanne, Thomas W. Dubensky
Publikováno v:
Cancer Immunology Research. 4:B020-B020
Stimulator of Interferon Genes (STING) is a critical component of the cytosolic DNA sensing pathway of the innate immune system. STING is activated by cyclic dinucleotides (CDNs), a product of the intracellular enzyme, cyclic GMP-AMP synthase (cGAS),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ae567e528562f50aa079258df68ea1f
https://doi.org/10.1158/2326-6066.imm2016-b020
https://doi.org/10.1158/2326-6066.imm2016-b020