559 Molecular characterization of Merkel cell carcinoma and association with Merkel cell polyomavirus

Autor: Curtis Perry, Kelsey Poorman, Ling Gao, Soo Park, Alex Farrell, Varsha Prakash, Sharon Wu, Sourat Darabi, Farah Abdulla

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/a847d895277f4f339ae9a5393f365aac

Comparison of the biomarkers for targeted therapies in primary extra‐mammary and mammary Paget's disease

Autor: Zoran Gatalica, Semir Vranic, Božo Krušlin, Kelsey Poorman, Phillip Stafford, Denisa Kacerovska, Wijendra Senarathne, Elena Florento, Elma Contreras, Alexandra Leary, April Choi, Gino K. In

Publikováno v: Cancer Medicine, Vol 9, Iss 4, Pp 1441-1450 (2020)

Abstract Background Primary Extra‐mammary Paget's disease (EMPD) is a very rare cutaneous adenocarcinoma affecting anogenital or axillary regions. It is characterized by a prolonged course with recurrences and eventually distant metastatic spread f

Externí odkaz: https://doaj.org/article/f88b08f4d8324c49a38f425e780ce858

Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis.

Autor: William P D Hendricks, Victoria Zismann, Karthigayini Sivaprakasam, Christophe Legendre, Kelsey Poorman, Waibhav Tembe, Nieves Perdigones, Jeffrey Kiefer, Winnie Liang, Valerie DeLuca, Mitchell Stark, Alison Ruhe, Roe Froman, Nicholas S Duesbery, Megan Washington, Jessica Aldrich, Mark W Neff, Matthew J Huentelman, Nicholas Hayward, Kevin Brown, Douglas Thamm, Gerald Post, Chand Khanna, Barbara Davis, Matthew Breen, Alexander Sekulic, Jeffrey M Trent

Publikováno v: PLoS Genetics, Vol 14, Iss 9, p e1007589 (2018)

Canine malignant melanoma, a significant cause of mortality in domestic dogs, is a powerful comparative model for human melanoma, but little is known about its genetic etiology. We mapped the genomic landscape of canine melanoma through multi-platfor

Externí odkaz: https://doaj.org/article/fb48d4dcfc8546dabf55f455902f3e75

Prevalence of class I–III BRAF mutations among 114,662 cancer patients in a large genomic database

Autor: Andrew Elliott, Geoffrey T. Gibney, Mohamed E. Salem, Jason Porter, Ari M. Vanderwalde, Steven J. O'Day, Jeff Owsley, Kelsey Poorman, Matthew K Stein, Gino K. In

Publikováno v: Exp Biol Med (Maywood)

BRAF mutations are relatively common in many cancers, particularly melanoma, colorectal cancer, and thyroid cancer and to a lesser extent in lung cancer. These mutations can be targeted by BRAF and MEK inhibitors, which exhibit good clinical activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be89a18f1f5664c672eac116b03563e
https://doi.org/10.1177/1535370220959657

Molecular profiling of signet-ring-cell carcinoma (SRCC) from the stomach and colon reveals potential new therapeutic targets

Autor: Alberto Puccini, Kelsey Poorman, Fabio Catalano, Andreas Seeber, Richard M. Goldberg, Mohamed E. Salem, Anthony F. Shields, Martin D. Berger, Francesca Battaglin, Ryuma Tokunaga, Madiha Naseem, Wu Zhang, Philip A. Philip, John L. Marshall, W. Michael Korn, Heinz-Josef Lenz

Publikováno v: Puccini, Alberto; Poorman, Kelsey; Catalano, Fabio; Seeber, Andreas; Goldberg, Richard M; Salem, Mohamed E; Shields, Anthony F; Berger, Martin D; Battaglin, Francesca; Tokunaga, Ryuma; Naseem, Madiha; Zhang, Wu; Philip, Philip A; Marshall, John L; Korn, W Michael; Lenz, Heinz-Josef (2022). Molecular profiling of signet-ring-cell carcinoma (SRCC) from the stomach and colon reveals potential new therapeutic targets. Oncogene, 41(26), pp. 3455-3460. Springer Nature 10.1038/s41388-022-02350-6
Oncogene

Signet ring cell carcinoma (SRCC) is rare: about 10% of gastric cancer (GC) and 1% of colorectal cancer (CRC). SRCC is associated with poor prognosis, however the underlying molecular characteristics are unknown. SRCCs were analyzed using NGS, immuno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9bac098a8cadd63e1de8a4fc6162a27