Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Kelsey L. Hanson"'
Autor:
Kelsey L. Hanson, Kyle E. Allen, Brooke M. VandenBrink, Wendel L. Nelson, Kent L. Kunze, Kantipudi N. Babu
Publikováno v:
Drug Metabolism and Disposition. 38:963-972
Three secondary amines desipramine (DES), (S)-fluoxetine [(S)-FLX], and N-desmethyldiltiazem (MA) undergo N-hydroxylation to the corresponding secondary hydroxylamines [N-hydroxydesipramine, (S)-N-hydroxyfluoxetine, and N-hydroxy-N-desmethyldiltiazem
Autor:
Eric Chun Yong Chan, Michelle D. Wahlin, Sidney D. Nelson, Hideo Takakusa, Lee Sun New, Chunsheng Zhao, Kelsey L. Hanson
Lapatinib, an oral breast cancer drug, has recently been reported to be a mechanism-based inactivator of cytochrome P450 (P450) 3A4 and also an idiosyncratic hepatotoxicant. It was suggested that formation of a reactive quinoneimine metabolite was in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b0c3c625b741a81a611a46fc9d64bd
https://europepmc.org/articles/PMC3100900/
https://europepmc.org/articles/PMC3100900/